scholarly journals Transmission of Tau Pathology from Human to Rodent Brain: How to Humanise Animal Models for Alzheimer’s Disease Research

2017 ◽  
Vol 07 (06) ◽  
Author(s):  
Tomas Smolek ◽  
Santosh Jadhav ◽  
Bernadeta Valachova ◽  
Thomas Vogels ◽  
Jaroslav Legath ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Models ◽  
Tau Pathology ◽  
Disease Research ◽  
Rodent Brain

Molecular Pathogenesis of the Tauopathies

2019 ◽  
Vol 14 (1) ◽  
pp. 239-261 ◽  
Author(s):  
Jürgen Götz ◽  
Glenda Halliday ◽  
Rebecca M. Nisbet
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Models ◽  
Frontotemporal Lobar Degeneration ◽  
Transgenic Animal ◽  
Molecular Pathogenesis ◽  
Common Denominator ◽  
Tau Pathology ◽  
Transgenic Animal Models

The tauopathies constitute a group of diseases that have Tau inclusions in neurons or glia as their common denominator. In this review, we describe the biochemical and histological differences in Tau pathology that are characteristic of the spectrum of frontotemporal lobar degeneration as primary tauopathies and of Alzheimer's disease as a secondary tauopathy, as well as the commonalities and differences between the familial and sporadic forms. Furthermore, we discuss selected advances in transgenic animal models in delineating the different pathomechanisms of Tau.

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