Diagnostic Characteristics of Psychosis and Autism Spectrum Disorder in Adolescence and Adulthood. A Case Series

Duplications of chromosome 16p11.2, even though rare in the general population, are one of the most frequent known genetic causes of autism spectrum disorder and of other neurodevelopmental disorders. However, data about the neuro-behavioral phenotype of these patients are few. We described a sample of children with duplication of chromosome 16p11.2 focusing on the neuro-behavioral phenotype. The five patients reported presented with very heterogeneous conditions as for characteristics and severity, ranging from a learning disorder in a child with normal intelligence quotient to an autism spectrum disorder associated with an intellectual disability. Our case report underlines the wide heterogeneity of the neuropsychiatric phenotypes associated with a duplication of chromosome 16p11.2. Similarly to other copy number variations that are considered pathogenic, the wide variability of phenotype of chromosome 16p11.2 duplication is probably related to additional risk factors, both genetic and not genetic, often difficult to identify and most likely different from case to case.

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Pharmacological Intervention in Children with Autism Spectrum Disorder with Standard Supportive Therapies Significantly Improves Core Signs and Symptoms: A Single-Center, Retrospective Case Series

Neuropsychiatric Disease and Treatment ◽

10.2147/ndt.s277294 ◽

2020 ◽

Vol Volume 16 ◽

pp. 2779-2794

Author(s):

Hamza A Alsayouf ◽

Haitham Talo ◽

Marisa L Biddappa ◽

Mohammad Qasaymeh ◽

Shadi Qasem ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Case Series ◽

Signs And Symptoms ◽

Children With Autism ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Pharmacological Intervention ◽

Single Center ◽

Retrospective Case ◽

Retrospective Case Series

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A phenomenological approach to diagnosing psychosis in autism spectrum disorder and intellectual disability: a case series

Advances in Autism ◽

10.1108/aia-01-2018-0004 ◽

2018 ◽

Vol 4 (2) ◽

pp. 39-48

Author(s):

Rahul Rai ◽

Samuel Tromans ◽

Chaya Kapugama ◽

Verity Chester ◽

Ignatius Gunaratna ◽

...

Keyword(s):

Quality Of Life ◽

Autism Spectrum Disorder ◽

Intellectual Disability ◽

Case Series ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Psychotic Symptoms ◽

Related Case ◽

Content Type

Purpose The diagnosis of psychosis in individuals with autism spectrum disorder (ASD) poses a unique clinical challenge. The presence of intellectual disability (ID) further complicates the diagnostic picture. Reliable and timely diagnosis of psychosis in such individuals minimises the duration of untreated psychotic symptoms and the subsequent impact on the quality of life of the patients concerned. The paper aims to discuss this issue. Design/methodology/approach The authors present four patients with psychosis, ASD and ID, who have received care within forensic mental health and ID settings. These examples demonstrate the interaction between these conditions, as well as issues pertaining to diagnosis and management. Findings In all four patients, sustained use of antipsychotic medication was objectively associated with an improvement in psychotic symptoms and quality of life. In instances where autistic phenomena were accentuated upon development of psychosis, such features returned to the baseline levels evident prior to the onset of psychosis. Practical implications The discussion and related case examples could improve the understanding of the possibility of psychosis in individuals with ASD and ID, and increase awareness of this diagnostic possibility among healthcare professionals. Originality/value This is the first published case series illustrating the challenges of diagnosing psychosis in individuals with ASD and ID.

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6.7 Cannabis-Induced Mania and Psychosis in Young Adult Males With Autism Spectrum Disorder: A Case Series and Literature Review

Journal of the American Academy of Child & Adolescent Psychiatry ◽

10.1016/j.jaac.2021.09.080 ◽

2021 ◽

Vol 60 (10) ◽

pp. S160

Author(s):

Majd Al-Soleiti ◽

Kayla Balaj ◽

Robyn Thom ◽

Christopher Keary ◽

Christopher McDougle

Keyword(s):

Autism Spectrum Disorder ◽

Young Adult ◽

Literature Review ◽

Case Series ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Adult Males ◽

Young Adult Males

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Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs

Journal of Autism and Developmental Disorders ◽

10.1007/s10803-021-05208-0 ◽

2021 ◽

Author(s):

Basmah H. Alfageh ◽

Frank M. C. Besag ◽

Le Gao ◽

Tian-Tian Ma ◽

Kenneth K. C. Man ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Chart Review ◽

Case Reports ◽

Case Series ◽

Antipsychotic Agents ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Increased Risk ◽

Study Designs ◽

Time Invariant

AbstractThere are many case reports of seizures apparently associated with the prescription of antipsychotics. This study aimed to examine whether there is an association between the prescription of antipsychotics and incident seizures in individuals with autism spectrum disorder using retrospective data based on patients’ chart review. A cohort study was conducted to compare the rate of incident seizure between 3923 users of antipsychotics with 10,086 users of other psychotropics. This was followed by a self-controlled case series (SCCS) analysis of 149 patients to eliminate the effect of time-invariant confounders. The results showed no evidence of increased risk of seizure after exposure to antipsychotic agents (Hazard Ratio 1.28, 95% CI 0.74–2.19) compared to other psychotropics.

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Causes and consequences of delayed diagnosis of autism spectrum disorder in forensic practice: a case series

Journal of Intellectual Disabilities and Offending Behaviour ◽

10.1108/jidob-10-2020-0017 ◽

2021 ◽

Vol ahead-of-print (ahead-of-print) ◽

Author(s):

Michael C.F. Smith

Keyword(s):

Autism Spectrum Disorder ◽

Delayed Diagnosis ◽

Case Series ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Adults With Autism ◽

Content Type ◽

First Case ◽

Forensic Practice ◽

Direct Benefits

Purpose The purpose of this paper is to highlight the difficulties in identifying adults with autism spectrum disorder (ASD) and to illustrate the consequences of late diagnoses in forensic settings. Design/methodology/approach This paper presents an overview of the literature relevant to the topic and presents the details of three clinical cases. Findings Delayed diagnosis is not uncommon in forensic services. Cases may remain unidentified for considerable periods despite being under evaluation from clinical teams. Diagnosis in forensic settings is challenged by case complexity. Barriers to prompt diagnosis include time, resources and clinical competency. Timely diagnosis may lessen the risk of future offences, improves clinical risk management and can bring direct benefits to those with the condition. Originality/value This is the first case series which explores the issue of late diagnosis in forensic settings. The illustration of the extent to which a diagnosis can be missed may prompt clinicians to review and identify missed cases. The discussion of the issue may also support services to review their approach to screening and diagnosis of ASD.

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