An Overview on Actual Knowledge About Immunohistochemical and Molecular Features of Vitality, Focusing on the Growing Evidence and Analysis to Distinguish Between Suicidal and Simulated Hanging

In forensic practice, the pathologist is often asked to determine whether a hanging was committed as suicide or as a simulated hanging (when a dead body is suspended after death). When exterior evidence of violence is absent and the crime scene investigation fails to identify useful proof, it is nearly impossible to tell whether the dead body was suspended or not. As a result, determining whether the ligature mark was created during life or not should rely on the research and demonstration of vital reactions on the ligature mark. The main purpose of this review article is to provide a summary of current knowledge about the histological and immunohistochemical characteristics of vitality in hanging. The authors also aim to identify the most significant vitality markers on ligature marks for further scientific validation and to propose a standardized diagnostic protocol for hanging. The study was conducted according to the Preferred Reporting Items for Systematic Review (PRISMA) Protocol. Relevant scientific papers were found from PubMed up to April 2021, using the following keywords: hanging AND skin AND vitality. Three main points were studied: ligature mark dehydration, immunological response to mechanical injury, and apoptosis induction as a result of the previous points. An increase in apoptosis is evident in the ligature mark (due to physical and chemical processes involved), as demonstrated by FLICE-inhibitory protein (FLIP) depletion. Immunohistochemical detection of Aquaporin 3 (AQP3) and increase in the concentration of different electrolytes rely solely on ligature mark dehydration. Also, microRNAs (MiRNAs) could become reliable forensic biomarkers for ligature mark vitality diagnosis in the near future. To ensure high reliability in court cases, forensic investigation in hanging should rely on modern and proven markers, even a mix of several markers.

Methodical Support for Conducting an Expert Research to Establish the Statute of Limitations for the Execution of Documents’ Requisites: Problems of Expert and Judicial Practice

The article addresses the problems of methodical support for establishing the statute of limitations when conducting a forensic document examination, directly affecting the admissibility of an expert’s opinion as evidence in legal proceedings. Establishing the statute of limitations for the execution of documents’ requisites is one of the most demanded tasks when considering all categories of cases – administrative, arbitration, civil, criminal. Analysis of the forensic practice of this type of examination in legal proceedings shows the application of various methods and approaches. Such variety raises questions among both the judicial and legal communities. For example, what existing methods are scientifically substantiated, tested, certified, lead to reliable results, and can be used to solve expert tasks? Which are unsuitable for the use in expert practice, and for what reasons?To confirm the suitability of their author’s developments for forensic examination, individual non-state experts provide various patents and certificates. How legal and permissible is this practice?The article offers a competent analysis of the current situation on the example of the widely used method of “wet copying”

Effects of Loading Conditions on the Pelvic Fracture Biomechanism and Discrimination of Forensic Injury Manners of Impact and Run-Over Using the Finite Element Pelvic Model

This study aimed to systematically simulate the responses of pelvic fracture under impact and run-over to clarify the effects of boundary and loading conditions on the pelvic fracture mechanism and provide complementary quantitative evidence for forensic practice. Based on the THUMS finite element model, we have validated the simulation performance of the model by a real postmortem human pelvis side impact experiment. A total of 54 simulations with two injury manners (impact and run-over), seven loading directions (0°, 30°, 60°, 90°, 270°, 300°, 330°), and six loading velocities (10, 20, 30, 40, 50, and 60 km/h) were conducted. Criteria of effective strain, Von-Mises stress, contact force, and self-designed normalized eccentricity were used to evaluate the biomechanism of pelvic fracture. Based on our simulation results, it’s challenging to distinguish impact from run-over only rely on certain characteristic fractures. Loads on the front and back were less likely to cause pelvic fractures. In the 30°, 60°, 300° load directions, the overall deformation caused a “diagonal” pelvic fracture. The higher is the velocity (kinetic energy), the more severe is the pelvic fracture. The contact force will predict the risk of fracture. In addition, our self-designed eccentricity will distinguish the injury manner of impact and run-over under the 90° loads. The “biomechanical fingerprints” based on logistic regression of all biomechanical variables have an AUC of 0.941 in discriminating the injury manners. Our study may provide simulation evidence and new methods for the forensic community to improve the forensic identification ability of injury manners.

Identifying biomarkers for evaluating wound extent and age in the contused muscle of rats using microarray analysis: a pilot study

Wound age estimation is still one of the most important and significant challenges in forensic practice. The extent of wound damage greatly affects the accuracy and reliability of wound age estimation, so it is important to find effective biomarkers to help diagnose wound degree and wound age. In the present study, the gene expression profiles of both mild and severe injuries in 33 rats were assayed at 0, 1, 3, 24, 48, and 168 hours using the Affymetrix microarray system to provide biomarkers for the evaluation of wound age and the extent of the wound. After obtaining thousands of differentially expressed genes, a principal component analysis, the least absolute shrinkage and selection operator, and a time-series analysis were used to select the most predictive prognostic genes. Finally, 15 genes were screened for evaluating the extent of wound damage, and the top 60 genes were also screened for wound age estimation in mild and severe injury. Selected indicators showed good diagnostic performance for identifying the extent of the wound and wound age in a Fisher discriminant analysis. A function analysis showed that the candidate genes were mainly related to cell proliferation and the inflammatory response, primarily IL-17 and the Hematopoietic cell lineage signalling pathway. The results revealed that these genes play an essential role in wound-healing and yield helpful and valuable potential biomarkers for further targeted studies.

Forensic application of static and dynamic risk factors: Is it the right time?

It is common, accepted clinical practice to conduct risk assessments of individuals who commit sexual offenses using the combination of sexual violence risk actuarial measures and dynamic risk factors. This assessment approach has utility when identifying treatment targets, assessing progress in sexual offender treatment, and forming risk management plans. Little research has examined this method in forensic contexts such as deciding whether individuals who suffer from mental disorders are likely to engage in sexually dangerous behavior as defined by sexually violent predator or persons (“SVP”) involuntary civil confinement laws in the USA. In particular, it is uncertain whether the combination of sexual violence risk actuarial measures and dynamic risk factors (DRF) produces sufficiently reliable, relevant, and probative evidence for the trier of fact to properly evaluate the SVP legally defined likelihood of sexual dangerousness. This article explores the efficacy of combining actuarial measures of sexual violence risk and dynamic risk factors as applied in SVP risk assessments based on some commonly observed forensic practices among evaluators. Based on the analysis, recommendations for forensic practice and future research are offered.

How Trauma May Magnify Risk of Involuntary and False Confessions Among Adolescents

Empirical research on police interrogation has identified both personal and situational factors that increase criminal suspects’ vulnerability to involuntary, unreliable, or false confessions. Although trauma exposure is a widely documented phenomenon known to affect adolescents’ perceptions, judgments, and behaviors in a wide array of contexts (especially stressful contexts), trauma history remains largely unexamined by interrogation researchers and virtually ignored by the courts when analyzing a confession. This article argues that trauma may operate as an additional personal risk factor for involuntary and false confessions among adolescents by generating both additive and interactive effects beyond youths’ general, developmentally-driven vulnerabilities in police interrogations. First, we briefly review adolescent trauma symptomatology, emphasizing the heterogeneity of adolescents’ responses to trauma. Next, using Leo and Drizin’s (2010) “Three Errors” framework of police-induced false confessions, we systematically apply clinical findings to each of the three police errors—misclassification, coercion, and contamination—to outline the psychological mechanisms through which adolescents with trauma histories may be at increased risk for making involuntary or unreliable statements to police. Finally, we offer considerations for interrogation research, clinical forensic practice, police practices, and courtroom procedures that could deepen our understanding of trauma’s role in the interrogation room, improve the integrity of investigative and adjudicatory processes, and ultimately promote justice for adolescent suspects with trauma exposure.

He Whakamāramatanga mo te Taihara: A Cultural-Ecological Perspective of Agency and Offending Behaviour

<p>This thesis aims to outline the important role of culture in the development of the human mind and behaviour, and therefore argues that cultural information is a key part of forensic explanation. Differing cultural experiences, such as marginalisation, contribute to the differential representation of individuals and groups in criminal justice systems. Although there are multiple means through which this occurs, this thesis focuses on the role of the individual agentic process, nested within a historically-derived cultural context. Building on previous theoretical work, a preliminary model – the Cultural-Ecological Predictive Agency Model – is presented that might better assist comprehensive explanation of offending behaviour with reference to cultural processes and concepts. The model is then applied to an exemplar, compared to current approaches to rehabilitation and desistance, and some implications for forensic practice are suggested. The overall goal of this thesis is to explicate the potential cultural impacts on individuals who commit offences, and examine some of the causes of offending beyond ‘faulty individual psychology’.</p>

He Whakamāramatanga mo te Taihara: A Cultural-Ecological Perspective of Agency and Offending Behaviour

<p>This thesis aims to outline the important role of culture in the development of the human mind and behaviour, and therefore argues that cultural information is a key part of forensic explanation. Differing cultural experiences, such as marginalisation, contribute to the differential representation of individuals and groups in criminal justice systems. Although there are multiple means through which this occurs, this thesis focuses on the role of the individual agentic process, nested within a historically-derived cultural context. Building on previous theoretical work, a preliminary model – the Cultural-Ecological Predictive Agency Model – is presented that might better assist comprehensive explanation of offending behaviour with reference to cultural processes and concepts. The model is then applied to an exemplar, compared to current approaches to rehabilitation and desistance, and some implications for forensic practice are suggested. The overall goal of this thesis is to explicate the potential cultural impacts on individuals who commit offences, and examine some of the causes of offending beyond ‘faulty individual psychology’.</p>

Zur Aufhebung von Scheinerinnerungen: Neue Befunde von Oeberst et al. (2021) und ihre aktuelle Übertragbarkeit in die forensische Praxis

A current finding by Oeberst et al. (2021) suggests a reversal of false memories of autobiographical events by means of source and false memory sensitization. The use of both techniques led to a significant reduction in the recollection quality of false memories in the sample examined. At the same time, the quality of memories of true experiences was barely diminished. Such results are seldom and significant, transferring them into forensic practice would be beneficial. However, if the meaningfulness and potential transferability of the results is examined more closely against the backdrop of forensic practice’s demands, it becomes apparent that using techniques in such a manner has not yet been sufficiently investigated and empirically verified. This applies to the psychological assessment of credibility as for the police questioning of witnesses. More details are discussed in the present article, whereby the study by Oeberst et al, its results, informative value and validity is successively and primarily referred to in relation to the psychological assessment of credibility.