The Influence of Metabolic Syndrome Components on N-Terminal Pro B-Type Natriuretic Peptide Concentrations: The Role of Left Ventricular Diastolic Dysfunction

Background: Brain natriuretic peptide (BNP) reflects left ventricular pressure. It increases in systolic dysfunction. Our aim was to evaluate role of plasma BNP level in early diagnosis of left ventricular isolated diastolic dysfunction. Methods: We studied 60 patients (male=18, female=42) with hypertension, diabetes mellitus, ischemic heart disease, dyslipidemia. The Doppler parameters used for evaluation of diastolic dysfunction are: isovolumetric relaxation time (IVRT), Transmitral flow velocities (E/A) ratio, deceleration time (DT) & pulmonary vein Doppler findings. 49 patients (group-1) had diastolic dysfunction whereas 11 patients (group-2) had normal flow patterns. Plasma BNP level was done in all patients. Results: Mean plasma BNP levels were 40.41±6.82 pg/ml in individuals with normal filling patterns and 183.36±25.28 pg/ml in subjects with abnormal diastolic dysfunction (p<0.001).The accuracy of BNP in detecting diastolic dysfunction was assessed with receiver-operating characteristic(ROC) analysis. The area under the ROC curve for BNP test accuracy in detection of any abnormal diastolic dysfunction was 0.928 (95% CI, 0.861 to 0.994;p<0.001).A BNP value of 63 pg/ml had the sensitivity of 89.9%,specificity of 91.9% and accuracy of 90.3%.PPVwas 97.8% and NPV-66.7% for detecting diastolic dysfunction. Conclusion: Raised plasma BNP level is useful for early diagnosis of isolated left ventricular Diastolic dysfunction. Key words: BNP; Diastolic dysfunction. DOI: 10.3329/cardio.v3i1.6419Cardiovasc. j. 2010; 3(1): 2-6

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287 Bridging the gap between increased aortic stiffness and early left ventricular diastolic dysfunction in essential hypertension: the role of brain natriuretic peptide

European Journal of Echocardiography ◽

10.1016/s1525-2167(05)80140-4 ◽

2005 ◽

Vol 6 ◽

pp. S35-S35

Keyword(s):

Essential Hypertension ◽

Brain Natriuretic Peptide ◽

Diastolic Dysfunction ◽

Natriuretic Peptide ◽

Aortic Stiffness ◽

Left Ventricular Diastolic Dysfunction ◽

Left Ventricular ◽

Ventricular Diastolic Dysfunction

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Non-alcoholic fatty liver disease and left ventricular diastolic dysfunction in patients with metabolic syndrome

Experimental and Clinical Gastroenterology ◽

10.31146/1682-8658-ecg-183-11-25-33 ◽

2020 ◽

Vol 183 (11) ◽

pp. 25-33

Author(s):

S. N. Jadhav ◽

V. G. Radchenko

Keyword(s):

Metabolic Syndrome ◽

Liver Disease ◽

Diastolic Dysfunction ◽

Liver Damage ◽

Fatty Liver Disease ◽

Left Ventricular Diastolic Dysfunction ◽

Left Ventricular ◽

Alcoholic Fatty Liver ◽

Ventricular Diastolic Dysfunction ◽

Alcoholic Fatty Liver Disease

The purpose of the study was to determine the frequency and nature of manifestations of left ventricular diastolic dysfunction in patients with non-alcoholic fatty liver disease with the background of metabolic syndrome (MS).Characteristics of patients and research methods: To solve this problem, 227 patients with MS (130 men and 97 women) were examined. The study was conducted in two phases. At the ﬁrst stage, all patients with MS are divided into two groups: patients with NAFLD — 205 people and 22 — without liver damage. At the next stage, a group of NAFLD patients with left ventricular DD (n=136) (66.34%) (the main group) and patients with no DD (n=69) (33.66%) (the comparison group) were identiﬁed.Results of the study: the results of diagnostics, clinical and laboratory manifestations of left ventricular diastolic dysfunction in 136 patients with NAFLD on the background of metabolic syndrome are Presented. Signiﬁcant factors of development and progression of diastolic dysfunction were identiﬁed, which include increased body weight and adipose tissue, insulin resistance, dyslipidemia, hyperuricemia, activity and stage of liver damage. According to the data of structural and functional changes in the myocardium, the role of diastolic dysfunction in the development of chronic heart failure in patients with NAFLD with manifestations of metabolic syndrome has been established.Conclusion: it was Found that the development of left ventricular diastolic dysfunction in patients with NAFLD is due to the morphofunctional state of the liver.

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