Lateral Hypothalamic Control of Energy Balance

2017 ◽  
Vol 9 (7) ◽  
pp. i-106
Author(s):  
Gizem Kurt ◽  
Hillary L. Woodworth ◽  
Gina M. Leinninger
Keyword(s):  
Energy Balance ◽  
Lateral Hypothalamic ◽  
Hypothalamic Control

scholarly journals Lateral Hypothalamic Area Neurotensin Neurons Are Required for Control of Orexin Neurons and Energy Balance

Endocrinology ◽  
2018 ◽  
Vol 159 (9) ◽  
pp. 3158-3176 ◽  
Author(s):  
Juliette Brown ◽  
Andrew Sagante ◽  
Thomas Mayer ◽  
Anna Wright ◽  
Raluca Bugescu ◽  
...  
Keyword(s):  
Body Weight ◽  
Locomotor Activity ◽  
Energy Balance ◽  
Large Population ◽  
Lateral Hypothalamic Area ◽  
Hypothalamic Area ◽  
Genetic Ablation ◽  
Lateral Hypothalamic ◽  
Adult Mice ◽  
Locomotor Behaviors

Abstract The lateral hypothalamic area (LHA) is essential for motivated ingestive and locomotor behaviors that impact body weight, yet it remains unclear how the neurochemically defined subpopulations of LHA neurons contribute to energy balance. In particular, the role of the large population of LHA neurotensin (Nts) neurons has remained ambiguous due to the lack of methods to easily visualize and modulate these neurons. Because LHA Nts neurons are activated by leptin and other anorectic cues and they modulate dopamine or local LHA orexin neurons implicated in energy balance, they may have important, unappreciated roles for coordinating behaviors necessary for proper body weight. In this study, we genetically ablated or chemogenetically inhibited LHA Nts neurons in adult mice to determine their necessity for control of motivated behaviors and body weight. Genetic ablation of LHA Nts neurons resulted in profoundly increased adiposity compared with mice with intact LHA Nts neurons, as well as diminished locomotor activity, energy expenditure, and water intake. Complete loss of LHA Nts neurons also led to downregulation of orexin, revealing important cross-talk between the LHA Nts and orexin populations in maintenance of behavior and body weight. In contrast, chemogenetic inhibition of intact LHA Nts neurons did not disrupt orexin expression, but it suppressed locomotor activity and the adaptive response to leptin. Taken together, these data reveal the necessity of LHA Nts neurons and their activation for controlling energy balance, and that LHA Nts neurons influence behavior and body weight via orexin-dependent and orexin-independent mechanisms.

Energy balance of rats with lateral hypothalamic lesions

1982 ◽  
Vol 242 (4) ◽  
pp. E273-E279 ◽  
Author(s):  
S. W. Corbett ◽  
R. E. Keesey
Keyword(s):  
Body Weight ◽  
Energy Balance ◽  
Energy Expenditure ◽  
Caloric Intake ◽  
Energy Utilization ◽  
Lateral Hypothalamic ◽  
Energy Needs ◽  
Body Weights ◽  
Maintain Body Weight

Rats with lateral hypothalamic (LH) lesions maintain body weight at a chronically reduced percentage of nonlesioned controls. An assessment of how they achieve energy balance at subnormal weight levels entailed a determination of both their energy intake and their energy expended or lost in processing ingested food, on basal heat production, on activity, and in feces or urine. It was found that the caloric intake and expenditure of LH-lesioned animals, though significantly lower than those of controls, were appropriate to the reduced metabolic body size (BW0.75) that they maintained. Likewise, energy expenditure in the LH-lesioned animals was normal in that the proportion of their ingested energy relegated to 1) basal metabolism, 2) the processing food, and 3) activity was the same as that of nonlesioned controls. Thus, unlike nonlesioned rats, which at lowered body weights both decrease their energy needs and reorder the pattern of energy expenditure, LH-lesioned animals display a normal pattern of energy utilization at reduced weight levels. These findings provide further evidence that lateral hypothalamic mechanisms play an important role in setting the level at which body weight is regulated.

Lateral Hypothalamic Leptin Receptor Neurons Containing Neurotensin Regulate Orexin Neurons, Energy Balance and the Mesolimbic Dopamine System

2011 ◽  
pp. P1-358-P1-358
Author(s):  
Gina M Leinninger ◽  
Darren M Opland ◽  
Young-Hwan Jo ◽  
Miro Faouzi ◽  
Lyndsay Christensen ◽  
...  
Keyword(s):  
Energy Balance ◽  
Leptin Receptor ◽  
Mesolimbic Dopamine ◽  
Dopamine System ◽  
Mesolimbic Dopamine System ◽  
Lateral Hypothalamic ◽  
Receptor Neurons

scholarly journals Hypothalamic Neuropeptide Expression of Juvenile and Middle-Aged Rats after Early Postnatal Food Restriction

Endocrinology ◽  
2008 ◽  
Vol 149 (7) ◽  
pp. 3617-3625 ◽  
Author(s):  
Floor Remmers ◽  
Linda A. W. Verhagen ◽  
Roger A. H. Adan ◽  
Henriette A. Delemarre-van de Waal
Keyword(s):  
Gene Expression ◽  
Body Size ◽  
Energy Balance ◽  
Paraventricular Nucleus ◽  
Food Restriction ◽  
Lateral Hypothalamic Area ◽  
Aged Rats ◽  
Middle Aged ◽  
Hypothalamic Area ◽  
Lateral Hypothalamic

Rats subjected to early postnatal food restriction (FR) show persistent changes in energy balance. The hypothalamus plays a major role in the regulation of energy balance. Therefore, we hypothesized that early postnatal food restriction induces developmental programming of hypothalamic gene expression of neuropeptides involved in this regulation. In the hypothalamus of juvenile and middle-aged rats that were raised in control (10 pups) or FR litters (20 pups), gene expression was investigated for neuropeptide Y (NPY), agouti-related protein (AgRP), proopiomelanocortin (POMC), and cocaine- and amphetamine-regulated transcript (CART) in the arcuate nucleus (ARC); CRH and TRH in the paraventricular nucleus; and melanin-concentrating hormone (MCH) and orexin in the lateral hypothalamic area. Early postnatal FR acutely and persistently reduced body size. Juvenile FR rats had significantly reduced CART gene expression and increased MCH expression. In middle-aged FR rats, POMC and CART mRNA levels were significantly reduced. The ratio between expression of the ARC orexigenic peptides (NPY and AgRP) and anorexigenic peptides (POMC and CART) was increased in juvenile, but not in middle-aged, FR rats. These results suggest that in neonatal rats, FR already triggers the ARC, and to a lesser extent the lateral hypothalamic area, but not the paraventricular nucleus, to increase expression of orexigenic relative to anorexigenic peptides. In addition, with enduring small body size and normalized hypothalamic gene expression, the adult FR rats appeared to have accepted this smaller body size as normal. This suggests that the body weight set-point was differently programmed in animals with early postnatal FR.

scholarly journals 0064 Lateral Hypothalamic Control of REM Sleep Expression During Ambient Temperature Warming

SLEEP ◽  
2018 ◽  
Vol 41 (suppl_1) ◽  
pp. A26-A27
Author(s):  
M H Schmidt ◽  
N Komagata ◽  
B Latifi
Keyword(s):  
Ambient Temperature ◽  
Rem Sleep ◽  
Lateral Hypothalamic ◽  
Hypothalamic Control
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