Histopathological Examination and Literature Review of Orthokeratinized Odontogenic Cyst

Abstract Objective Orthokeratinized odontogenic cyst is a rare developmental odontogenic cyst of the jaws. It is a less aggressive intraosseous cyst identified by an orthokeratinized epithelium. Case Report A 50-year-old male patient with the chief complaint of swelling in the anterior part of his face, and, intraorally, there was diffuse swelling in the palatal cortex. On panoramic radiography, there was a well-defined unilocular radiolucency on the right side of the maxilla and palatal cortical expansion, and thinning of the buccal and palatal cortexes was observed. The histopathological examination revealed a pathologic cyst that was lined by a thick orthokeratinized epithelium. Therefore, the diagnosis was orthokeratinized odontogenic cyst. Conclusion The orthokeratinized odontogenic cyst displays characteristic clinical, histopathological, and biological features that differ significantly from those of keratocystic odontogenic tumor (KCOT), but it has a better prognosis and lower recurrence rate. Thus, other radiolucent lesions of the jaws, including keratocystic odontogenic tumor (KCOT), must be considered in the differential diagnosis.

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Orthokeratinized odontogenic cyst: a large series and comprehensive literature review with emphasis on synchronous multiple occurrence and neoplastic transformation

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2021.07.009 ◽

2021 ◽

Author(s):

Kyu-Young Oh ◽

Jo-Eun Kim ◽

Sung-Dae Cho ◽

Hye-Jung Yoon ◽

Jae-Il Lee ◽

...

Keyword(s):

Literature Review ◽

Neoplastic Transformation ◽

Large Series ◽

Odontogenic Cyst ◽

Orthokeratinized Odontogenic Cyst ◽

Comprehensive Literature Review ◽

Multiple Occurrence

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Glandular odontogenic cyst in mandible: A case report and literature review

Journal of Oral and Maxillofacial Surgery Medicine and Pathology ◽

10.1016/j.ajoms.2021.11.006 ◽

2021 ◽

Author(s):

Kenji Odashima ◽

Shinnosuke Nogami ◽

Jun Kitamura ◽

Ryosuke Iwama ◽

Yuta Yanagisawa ◽

...

Keyword(s):

Case Report ◽

Literature Review ◽

Odontogenic Cyst ◽

Glandular Odontogenic Cyst

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Orthokeratinized Odontogenic Cyst: A Clinicopathologic Study of 61 Cases

Archives of Pathology & Laboratory Medicine ◽

10.5858/134.2.271 ◽

2010 ◽

Vol 134 (2) ◽

pp. 271-275 ◽

Cited By ~ 10

Author(s):

Qing Dong ◽

Shuang Pan ◽

Li-Sha Sun ◽

Tie-Jun Li

Keyword(s):

Odontogenic Cyst ◽

World Health ◽

Keratocystic Odontogenic Tumor ◽

Impacted Tooth ◽

Ki 67 ◽

Orthokeratinized Odontogenic Cyst ◽

Clinicopathologic Study ◽

Mandibular Molar ◽

Health Organization

Abstract Context.—Orthokeratinized odontogenic cyst (OOC) is a relatively uncommon developmental cyst comprising about 10% of cases that had been previously coded as odontogenic keratocysts. Odontogenic keratocyst was designated as keratocystic odontogenic tumor (KCOT) in the new World Health Organization classification and OOC should be distinguished from KCOT for differences in histologic features and biologic behavior. Objective.—To analyze the clinicopathologic features of 61 cases of OOC in a Chinese population. Design.—Clinicopathologic analysis was performed on 61 cases of OOC. Immunohistochemical expression of Ki-67 and p63 was evaluated in 15 OOCs and 15 typical KCOTs. Results.—The 61 patients with OOC ranged from 13 to 75 years (average, 38.93 years). The lesions developed mainly in the third and fourth decades (57.38%) with a distinct predilection for males (72.13%). Six (9.84%) lesions were found in the maxilla and 55 (90.16%) in the mandible. The most common sites were in the mandibular molar and ramus region. Of the 54 cases with radiographic record, 47 (87.04%) were unilocular and 7 (12.96%) were multilocular radiolucencies. Twenty-seven of the 54 cysts were associated with an impacted tooth. Follow-up of 42 patients revealed no recurrence during an average period of 76.8 months after surgery. Compared with KCOTs, expression level of Ki-67 and p63 was significantly lower in OOCs, suggesting a lower proliferative activity. Conclusion.—Orthokeratinized odontogenic cyst is clinicopathologically distinct from KCOT and should constitute its own clinical entity.

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Solitary Schwannoma on the Hypothenar Region of the Hand: A Literature Review

International Journal of Innovative Research in Medical Science ◽

10.23958/ijirms/vol05-i10/967 ◽

2020 ◽

Vol 5 (10) ◽

pp. 449-452

Author(s):

Kastanis G ◽

Kapsetakis P ◽

Magarakis G ◽

Bachlitzanaki M ◽

Christoforidis C ◽

...

Keyword(s):

Literature Review ◽

Clinical Diagnosis ◽

Peripheral Nerves ◽

Histopathological Examination ◽

Final Diagnosis ◽

Benign Tumors ◽

Rare Manifestation ◽

Histopathological Evidence ◽

Volar Surface

Schwannomas or neurilemmomas are the most common benign tumors of the neural sheaths of the peripheral nerves. Incidence of these tumors in the hand accounts to 0.8-2%. The majority of them appear as an isolated grown mass along the route of the nerves. Peripheral nerves benign tumors present many difficulties concerning the clinical diagnosis and only histopathological evidence provides the final diagnosis. In this case study, we present a 45 year old man with a grown asymptomatic mass on the volar surface of right hand (hypothenar) remained for two years and impinging the skin of the hand only the last months. Initial MRI results diagnosed the mass as gaglion cyst. Histopathological examination revealed a schwannoma. We present this case as a rare manifestation of a schwannoma in hypothenar area of the hand. A literature review of diagnoses and therapeutic management is also presented.

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