scholarly journals Solitary Schwannoma on the Hypothenar Region of the Hand: A Literature Review

2020 ◽  
Vol 5 (10) ◽  
pp. 449-452
Author(s):  
Kastanis G ◽  
Kapsetakis P ◽  
Magarakis G ◽  
Bachlitzanaki M ◽  
Christoforidis C ◽  
...  
Keyword(s):  
Literature Review ◽  
Clinical Diagnosis ◽  
Peripheral Nerves ◽  
Histopathological Examination ◽  
Final Diagnosis ◽  
Benign Tumors ◽  
Rare Manifestation ◽  
Histopathological Evidence ◽  
Volar Surface

Schwannomas or neurilemmomas are the most common benign tumors of the neural sheaths of the peripheral nerves. Incidence of these tumors in the hand accounts to 0.8-2%. The majority of them appear as an isolated grown mass along the route of the nerves. Peripheral nerves benign tumors present many difficulties concerning the clinical diagnosis and only histopathological evidence provides the final diagnosis. In this case study, we present a 45 year old man with a grown asymptomatic mass on the volar surface of right hand (hypothenar) remained for two years and impinging the skin of the hand only the last months. Initial MRI results diagnosed the mass as gaglion cyst. Histopathological examination revealed a schwannoma. We present this case as a rare manifestation of a schwannoma in hypothenar area of the hand. A literature review of diagnoses and therapeutic management is also presented.

scholarly journals The Frequency and Causes of Subepidermal Gaps or Blisters and the Compliance Rate Between Clinical Diagnosis and Pathology Reports from 2015 to 2019

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Abbas Darjani ◽  
Hojat Eftekhari ◽  
Seyedeh Rojin Amini Rad ◽  
Narges Alizadeh ◽  
Rana Rafiee ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Skin Diseases ◽  
Histopathological Examination ◽  
Compliance Rate ◽  
Clinical Manifestations ◽  
Final Diagnosis ◽  
Direct Immunofluorescence ◽  
Diagnostic Challenge ◽  
Cross Sectional ◽  
Pathology Reports

Background: Skin diseases are the fourth most common cause of human illness, and blisters with different clinical manifestations make a diagnostic challenge. Objectives: This study aimed to evaluate the frequency and causes of subepidermal gaps or blisters, as well as the compliance rate between the initial and final clinical diagnoses based on pathology reports. Methods: In this cross-sectional study, pathology reports of subepidermal blisters or gaps were evaluated in the patients referred to the Razi Laboratory of Rasht from 2015 to 2019. The samples were examined by a pathologist after hematoxylin and eosin staining. The reports included demographic information, clinical differential diagnoses, final diagnosis, direct immunofluorescence findings, and salt split results. Finally, the compliance rate of clinical diagnosis with pathology reports was determined. Results: A total of 183 pathology reports were evaluated, 170 of which contained the final diagnosis. Females were more frequently affected by the disease, and pemphigoid bolus and lichen planus were the most prevalent final diagnoses. The compliance rate between the initial and final diagnoses was 94%. About 37.2% of the reports lacked direct immunofluorescence (DIF) and salt split, and only 42.6% of the samples had undergone DIF examination, while 20.2% had both DIF and salt split. There was no significant association between the compliance rate of the final diagnosis with age, sex, and undergoing diagnostic tests. Conclusions: A high incidence of subepidermal gaps or blisters was seen in middle-aged individuals and females. The compliance rate of the initial clinical diagnosis with the final diagnosis based on pathological reports was high. Our findings emphasize the importance of histopathological examination and the complementary role of direct immunofluorescence and salt split in diagnosis.

Lucio Phenomenon: A Rare Manifestation of Leprosy in Selangor, Malaysia

2021 ◽  
Vol 5 (0-2) ◽  
pp. 20
Author(s):  
Shahrizan Majid Binti Allapitchai
Keyword(s):  
Peripheral Nerves ◽  
Histopathological Examination ◽  
Skin Condition ◽  
Lepromatous Leprosy ◽  
Lower Limbs ◽  
Who Guidelines ◽  
Rare Manifestation ◽  
Hands And Feet ◽  
Multiple Ulcers ◽  
Made In

Leprosy is a chronic infectious disease caused by Mycobacterium leprae, predominantly affecting the skin and peripheral nerves. Lucio phenomenon is a rare reactional state presenting in patient with lepromatous leprosy and described as acute cutaneous necrotising vasculitis. We discussed the case of a 38-year-old male patient presenting with oedematous and dusky discolouration of bilateral hands and feet associated with diffuse facial involvement. His skin condition gradually worsened to form multiple ulcers with bizarre shaped purpuric lesion over bilateral upper and lower limbs, trunk, and face. Histopathological examination of the skin biopsy showed multiple acid-fast bacilli and diagnosis of Lucio’s phenomenon was made in the background of lepromatous leprosy. He was treated with multi drug therapy (MDT) as recommended by the WHO guidelines. A better understanding of rarer manifestation of this illness is important for early diagnosis and to prevent significant morbidity associated with it.International Journal of Human and Health Sciences Supplementary Issue-2: 2021 Page: S20

scholarly journals Amoebic Colitis Presenting as Subacute Intestinal Obstruction with Perforation

2020 ◽  
pp. 58-62
Author(s):  
Renuka Verma ◽  
Archana Budhwar ◽  
Priyanka Rawat ◽  
Niti Dalal ◽  
Anjali Bishlay ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Iliac Fossa ◽  
Abdominal Distension ◽  
Final Diagnosis ◽  
Free Fluid ◽  
Abdominal Radiography ◽  
Plain Abdominal Radiography ◽  
Amoebic Colitis ◽  
Subacute Intestinal Obstruction

Infestation with Entamoeba histolytica is worldwide, especially in developing areas. Presented case study included amoebic colitis in a 45 years old man complaining of abdominal distension and non-passage of stools since three days. Abdominal region was diffusely distended and tender in right iliac fossa. Plain abdominal radiography revealed prominent gut loops and minimal intergut free fluid. At laparotomy, malrotation of gut was present. Histopathological examination of intestinal samples confirmed final diagnosis of amoebic colitis post-operatively.

scholarly journals Benign Sinonasal Masses: A Clinicopathological and Radiological Profile

2014 ◽  
Vol 11 (1) ◽  
pp. 4-8 ◽  
Author(s):  
A Nepal ◽  
ST Chettri ◽  
RR Joshi ◽  
S Karki
Keyword(s):  
Paranasal Sinus ◽  
Nasal Polyps ◽  
Histopathological Examination ◽  
Treatment Plan ◽  
Final Diagnosis ◽  
Benign Tumors ◽  
Ossifying Fibroma ◽  
Fungal Sinusitis ◽  
Imaging Studies ◽  
Inverted Papillomas

Background Benign nasal and paranasal sinus masses are commonly encountered in clinical practice. Though benign, certain nasal polyps, fungal sinusitis, hemangiomas and fibro-osseous tumors can present with locally destructive features and deformities, mimicking malignancies at once. Objective This study was carried out to recognize the great variety of benign nasal lesions and their frequency in our region. Methods A retrospective chart analysis of cases presenting as mass in nose and paranasal sinus that underwent surgery over three years duration at our institute was done. A provisional diagnosis was made after clinical assessment and radiological investigations, but the final diagnosis was established after histopathological examination. Results A total 331 cases presented as masses in nose and paranasal sinus presented during the period. The clinicopathological examination aided by endoscopic and imaging studies revealed the non neoplastic benign masses in 293 and neoplastic masses in 38. Polyps were the commonest lesions constituting 70% cases followed by rhinosporidiosis in 10%. Fungal sinusitis, squamous papillomas, hemangiomas and inverted papillomas were found to be in order of 4.5%, 4%, 3.5% and 3% respectively. Rare cases like “rhino-oto-cereberal” form of mucormycosis, angiomyoma, and psammomatoid ossifying fibroma were also observed in the study. Conclusion Most of the nasal polyps/fungal sinusitis can be diagnosed clinically. However many a times Computer tomography (CT) scan and biopsy are necessary to differentiate them from each other and treatment plan. Certain benign tumors have high potential for malignant transformation while others can present with locally destructive features and deformities. DOI: http://dx.doi.org/10.3126/kumj.v11i1.11015 Kathmandu University Medical Journal Vol.11(1) 2013: 4-8

scholarly journals HISTOPATHOLOGICAL SPECTRUM OF SALIVARY GLAND LESIONS WITH CLINICAL CORRELATION

2020 ◽  
pp. 1-3
Author(s):  
Radhika Mucharla ◽  
Ravikanth Kotagiri
Keyword(s):  
Salivary Gland ◽  
Clinical Laboratory ◽  
Malignant Tumors ◽  
Histopathological Examination ◽  
Final Diagnosis ◽  
Research Centre ◽  
Benign Tumors ◽  
Salivary Gland Tumours ◽  
Chronic Sialadenitis ◽  
Neoplastic Lesions

Salivary gland tumours account for 2-6.5% of all the neoplasms of the Head and Neck. Histopathology is most important in diagnosis of salivary gland tumors. AIMS and OBJECTIVES : To study age,sex and site distribution of various salivary gland lesions, to study the histomorphologic (gross &microscopic) aspect of these lesions to correlate clinical diagnosis with that of histopathologic features. MATERIALS AND METHODS: The study is conducted in the RAINBOW CLINICAL LABORATORY AND RESEARCH CENTRE, SIDDIPET during the period of September2018 to September 2020. Formalin fixed ,paraffin embedded sections and stained with hematoxylin and eosin slides were studied. RESULTS: Total number of specimens were 54. Out of these 39 were neoplastic (benign 70%,malignant 30%) and 15 were non neoplastic. Among the benign tumors majority are pleomorphic adenoma.Among the malignant tumors, mucoepidermoid carcinoma is the most common. Among the non neoplastic lesions chronic sialadenitis is most common. CONCLUSION: Histopathological examination of salivary gland lesions stands out to be the most important method in establishing the final diagnosis. It helps in differentiating non neoplastic and neoplastic lesions.

scholarly journals Peripheral odontogenic myxoma: Clinical case with a literature review

2021 ◽  
Vol 10 (6) ◽  
pp. e26910615797
Author(s):  
Carlos Eduardo Nogueira Nunes ◽  
Anne Diolina Araújo Morais ◽  
João Victor Morais de Lima ◽  
Filipe Nobre Chaves ◽  
Marcelo Bonifácio da Silva Sampieri ◽  
...  
Keyword(s):  
Literature Review ◽  
Histopathological Examination ◽  
Excisional Biopsy ◽  
Final Diagnosis ◽  
Ossifying Fibroma ◽  
Histopathological Diagnosis ◽  
Odontogenic Myxoma ◽  
Long Term Follow Up ◽  
The Right ◽  
Age Range

Peripheral odontogenic myxoma (POM) is a rare and extra-osseous variant of odontogenic myxoma (OM), classified as a relatively rare benign odontogenic tumor, yet presenting locally aggressive behavior. The objective this manuscript is to report a case of POM in a 75-year-old patient, located in the right maxilla, and in addition, to perform a literature review of the data in relation to clinical, radiographic aspects, hypothesis of diagnosis, and treatment. A male patient, 75 years old, clinical examination constact the presence of a nodule, with a smooth surface, on the right upper alveolar ridge, measuring 20 x 25 mm, with a color similar to the mucosa, a softened consistency, involving teeth 14 and 15, and with an undetermined time of evolution was observed. The diagnostic hypothesis was a peripheral ossifying fibroma and differential diagnosis of peripheral giant cell lesion. An excisional biopsy was performed together with extraction of the involved teeth. Histopathological examination and histochemical reaction was confirm the histopathological diagnosis of POM. The reported case is extremely rare due to the clinical presentation of the lesion, causing bone resorption with tooth mobility. In addition, the age range of involvement is very different from that presented in the literature, between the second and fourth decade of life. The final diagnosis was very important, as it is a lesion with a great potential for recurrence, long-term follow-up should be more careful, and in case of recurrence, a new intervention must be performed.

scholarly journals Brainstem intraparenchymal schwannoma: A case report and literature review

2021 ◽  
Vol 12 ◽  
pp. 508
Author(s):  
Anselmi Kovalainen ◽  
Roel Haeren ◽  
Anders Paetau ◽  
Martin Lehecka
Keyword(s):  
Literature Review ◽  
Histopathological Examination ◽  
Case Reports ◽  
Young Patients ◽  
Postoperative Recovery ◽  
Gross Total Resection ◽  
Benign Tumors ◽  
Mri Imaging ◽  
Total Resection ◽  
Radiological Features

Background: Intracranial intraparenchymal schwannomas (IS) are rare tumors that have mainly been described in case reports. Here, we report on a case of a brainstem IS and included a comprehensive literature review. Case Description: A 74-year-old man presented with progressive gait disturbances. CT- and MRI-imaging revealed a contrast-enhancing mass accompanied by a cyst in the dorsolateral pons. Hemangioblastoma was suspected and surgery was advised. During surgery, gross total resection of a non-invasive tumor was performed. Postoperative recovery was uneventful. Based on histopathological examination, the intraparenchymal brainstem tumor was diagnosed as schwannoma. Conclusion: Our extensive review illustrates that ISs are benign tumors that most often present in relatively young patients. Malignant cases have been described but form an extremely rare entity. Preoperative diagnosis based on radiological features is difficult but should be considered when peritumoral edema, calcifications, and cysts are noted. In benign cases, gross total resection of the lesion is curative. To adequately select this treatment and adjust the surgical strategy accordingly, it is important to include IS in the preoperative differential diagnosis when the abovementioned radiological features are present.

scholarly journals Clinicopathological Evaluation of Eyelid and Conjunctival Lesions in Patients of Farshchian Hospital in Hamadan

2018 ◽  
Vol 3 (3) ◽  
pp. 120
Author(s):  
Fateme Eslami ◽  
Hamidreza Ghasemibasir
Keyword(s):  
Clinical Diagnosis ◽  
Malignant Tumors ◽  
Histopathological Examination ◽  
Age Groups ◽  
Final Diagnosis ◽  
Histological Diagnosis ◽  
Bulbar Conjunctiva ◽  
Benign Lesions ◽  
Cross Sectional ◽  
Clinical Appearance

Introduction: The lesions of the eyelid and conjunctiva are benign and malignant. The ratio of benign lesions is more than the malignant, increases with age, and are easily diagnosed clinically. However, in some cases, the clinical diagnosis of malignant tumors is impossible, necessitating the final diagnosis by histopathological examination. The incidence of benign and malignant tumors differs between countries according to the genetics of the racial population or environmental factors.Materials and methods: This cross-sectional descriptive study was conducted on 424 patients with eyelid and conjunctival lesions from the Farshchian Hospital of Hamadan between 2010–2014. The final pathological report, clinical diagnosis, demographic variables including age and gender, site of lesions, and clinical appearance were extracted from medical records.Results: The lesions consisted of 159 (37.5%) eyelid and 265 (62.5%) conjunctival lesions. The predominant location was bulbar conjunctiva (35.1%), and the least was external canthus (1.7%). The most frequent lesion based on clinical diagnosis was pterygium (51.7%), and the least frequent was sebaceous glands carcinoma. The most frequent lesion based on histological diagnosis was pterygium (52.5%), and the least frequent was xanthelasma. In this study, the concordance between clinical and histological diagnosis was 90.3% that indicated the physician’s accurate diagnosis.Conclusion: According to this study, the frequency of eyelid and conjunctival lesion was similar in males and females. The prevalence of lesions in >60-year-olds is more common than that in other age groups. The benign lesions of eyelids and conjunctiva are common than malignant lesions. Despite high clinicopathological concordance, the physician should always consider the rare cases, and the pathological diagnosis must be considered for all specimens.

scholarly journals Schwanomma arising from mental nerve: a rare entity

2016 ◽  
Vol 2 (10) ◽  
pp. 265
Author(s):  
Ratna Priya ◽  
Nitish Virmani ◽  
J. P. Dabholkar
Keyword(s):  
Peripheral Nerves ◽  
Neck Region ◽  
Immunohistochemical Analysis ◽  
Final Diagnosis ◽  
Benign Tumors ◽  
Mental Nerve ◽  
Lower Lip ◽  
Head And Neck Region ◽  
Single Well ◽  
High Index Of Suspicion

<p>Schwannomas or neurilemmomas are benign tumors of the nerve sheath that are single, well encaspsulated, bening and arise from the perineural schwann cells. They may arise either in central or peripheral nerves. Approximately 25–45% of all schwannomas are present in the head and neck region. The overall incidence of intra-oral schwanommas is 1% with most common site being tongue followed by buccal mucosa and lastly lip and gingival. Here we present a case report of lower lip schwanomma arising from mental nerve. On physical examination, a smooth globular swelling was present in the lower lip on right side, 2 cm × 3 cm in size and of firm, non-tender in character with regular margins. The patient underwent surgery and the lesion was excised intraorally with sublabial incision. Final pathological diagnosis was made as “schwannoma.” The patient has been following up for 6 months and there is no evidence of any recurrence. High index of suspicion is required and Schwannoma should be considered as a differential diagnosis in oral cavity bening lesions. The final diagnosis is based on histopathology report and immunohistochemical analysis. The treatment of these tumors is complete resection. The prognosis of such cases is extremely good, without any recurrence.</p>

scholarly journals Peripheral Nerve Schwannomas: A Literature Review

2019 ◽  
Vol 38 (04) ◽  
pp. 308-314 ◽  
Author(s):  
Marcelo José Silva Magalhães ◽  
Douglas Vitor Maia Pereira ◽  
Henrique Nunes Pereira Oliva ◽  
Dayane Tabatha Santos Durães ◽  
Fernanda Leal Caiado ◽  
...  
Keyword(s):  
Literature Review ◽  
Peripheral Nerve ◽  
Present Article ◽  
Myelin Sheath ◽  
Surgical Complications ◽  
Peripheral Nerves ◽  
Benign Tumors ◽  
The Third ◽  
Pubmed Database

Abstract Introduction Schwannomas are benign tumors originating from the cells, which wrap around axons that are usually encapsulated and solitary. These tumors usually lead to little or no symptomatology. They are usually the most common peripheral nerve tumors in adults, with their highest incidence between the third and fifth decades of life. Objective To perform a review about schwannoma of the peripheral nerves, presenting its definition, epidemiology, diagnosis, symptomatology and treatment. Methodology This is a descriptive work, based on a review of articles available in the PubMed database with the descriptors schwannoma and peripheral nerves. Results and Discussion Only papers published between 1981 and 2019, describing studies in humans, and that were available as full articles were selected. A total of 391 articles were included; after reading the titles, we noted that 67 articles fit the topic of the present study. Among the articles selected for reading, 33 fit the objectives of the present work, and were considered for the writing of the present article. Conclusion Schwannomas are benign myelin sheath tumors that develop with local symptomatology or asymptomatic and present a good surgical prognosis with generally reduced rates of surgical complications.

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