Sirolimus-eluting stent versus bare metal stent in diabetic patients: the final five-year follow-up of the DIABETES trial

2013 ◽  
Vol 9 (3) ◽  
pp. 328-335 ◽  
Author(s):  
Pilar Jiménez-Quevedo ◽  
Lorenzo Hernando ◽  
Joan Antoni Gómez-Hospital ◽  
Andrés Iñiguez ◽  
Alberto SanRoman ◽  
...  
Keyword(s):  
Bare Metal Stent ◽  
Diabetic Patients ◽  
Bare Metal ◽  
Metal Stent ◽  
Sirolimus Eluting Stent

Abstract 3322: Chronic Vascular Responses To Sirolimus-eluting Stent Compared With Bare-metal Stent In Diabetic Patients: Evaluated By Optical Coherence Tomography.

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Takashi Kubo ◽  
Toshio Imanishi ◽  
Hiroki Matsumoto ◽  
Manabu Kashiwagi ◽  
Hiroto Tsujioka ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Neointimal Hyperplasia ◽  
Bare Metal Stent ◽  
Diabetic Patients ◽  
Imaging Method ◽  
Bare Metal ◽  
Optical Coherence ◽  
Metal Stent ◽  
Cross Sectional ◽  
Sirolimus Eluting Stent

OBJECTIVE: An optical coherence tomography (OCT) study was performed to compre the vascular response to sirolimus-eluting stent (SES) with bare-metal stent (BMS) in patients with diabetic mellitus (DM). BACKGROUND: Despite advances in the medical treatment and revascularization procedures, coronary artery disease remains a leading cause of morbidity and mortality in patients with DM. Few retrospective subgroup analyses of pivotal clinical trials have suggested that SES may be effective for reduction of restenosis in diabetic patients. OCT is a new intravascular imaging method with a high resolution of approximately 10 micrometer and allows us to evaluate instent neointimal hyperplasia (NIH) in vivo. METHODS and RESULTS: Serial OCT analyses were performed in 60 lesions (SES in DM patients=19; SES in non-DM patients=14; BMS in DM patients=10; BMS in non-DM patients=17) at 9-month follow-up. A total of 6920 stent struts were visualized by OCT and NIH thickness inside each strut and incidence of exposed stnet struts were evaluated in cross-sectional image. The NIH thickness was significantly different among 4 groups (97 +/− 100 vs. 43 +/− 61 vs. 425 +/− 206 vs. 209 +/− 138 micrometer, respectively). The NIH thickness of SES in DM was significantly thicker than that of SES in non-DM (p<0.001), although it was significantly thinner than that of BMS in DM (p<0.001) or BMS in non-DM (p<0.001). All struts of BMS were covered by neointima, but 14% of struts of SES were exposed. The incidence of exposed struts and exposed struts with inadequate apposition in DES were significantly lower in DM compared with those in non-DM (5% vs. 34%, p<0.0001; 2% vs. 5%, p <0.001, respectively). Moreover, the frequency of DES with partially exposed strut was significantly lower in DM than non-DM (32% vs. 71%, p<0.027). CONCLUSION: The present OCT study revealed that DES inhibited the NIH effectively with low incidence of exposed stent strut in DM patients at 9-month after implantation.

scholarly journals TCT-184 Late Adverse Events After Implantation of Sirolimus-eluting Stent and Bare-metal Stent: 4-7 years follow-up of the CREDO-Kyoto Registry Cohort-2

2013 ◽  
Vol 62 (18) ◽  
pp. B60 ◽  
Author(s):  
Masahiro Natsuaki ◽  
Takeshi Morimoto ◽  
Yutaka Furukawa ◽  
Yoshihisa Nakagawa ◽  
Kazushige Kadota ◽  
...  
Keyword(s):  
Adverse Events ◽  
Bare Metal Stent ◽  
Bare Metal ◽  
Metal Stent ◽  
Sirolimus Eluting Stent

scholarly journals Comparison of Long-Term Angiographic Follow-Up After Sirolimus-Eluting Stent and Bare-Metal Stent Implantation

2008 ◽  
Vol 47 (4) ◽  
pp. 201-204 ◽  
Author(s):  
Nobuo Shiode ◽  
Kinya Shirota ◽  
Kenji Goto ◽  
Akinori Sairaku ◽  
Shinya Mikami ◽  
...  
Keyword(s):  
Stent Implantation ◽  
Bare Metal Stent ◽  
Bare Metal ◽  
Metal Stent ◽  
Sirolimus Eluting Stent

Long-Term Clinical Follow-up after Sirolimus-Eluting Stent versus Bare Metal Stent Implantation in Patients with Acute Coronary Syndrome

2009 ◽  
Vol 22 (3) ◽  
pp. 216-221 ◽  
Author(s):  
MANABU OGITA ◽  
TOMOHIRO NAKAMURA ◽  
NAOKI FUJIWARA ◽  
KENICHI SAKAKURA ◽  
HIROSHI FUNAYAMA ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Stent Implantation ◽  
Bare Metal Stent ◽  
Bare Metal ◽  
Metal Stent ◽  
Coronary Syndrome ◽  
Sirolimus Eluting Stent

Overlapping hybrid stenting with a sirolimus-eluting stent and a bare metal stent

2007 ◽  
Vol 118 (1) ◽  
pp. e8-e10 ◽  
Author(s):  
Masamichi Takano ◽  
Daisuke Murakami ◽  
Kyoichi Mizuno
Keyword(s):  
Bare Metal Stent ◽  
Bare Metal ◽  
Metal Stent ◽  
Sirolimus Eluting Stent

scholarly journals Effectiveness of a Sirolimus-Eluting Stent (Cypher ® ) for Diffuse In-Stent Restenosis Inside a Bare Metal Stent

2006 ◽  
Vol 47 (5) ◽  
pp. 651-661 ◽  
Author(s):  
Hiroshi Sakamoto ◽  
Tetsuya Ishikawa ◽  
Makoto Mutoh ◽  
Hisayuki Okada ◽  
Tetsushi Tsurusaki ◽  
...  
Keyword(s):  
Bare Metal Stent ◽  
Bare Metal ◽  
Metal Stent ◽  
Stent Restenosis ◽  
Sirolimus Eluting Stent ◽  
In Stent Restenosis

Patients with in-stent restenoses

2007 ◽  
Vol 46 (05) ◽  
pp. 185-191 ◽  
Author(s):  
T. Nusser ◽  
B. J. Krause ◽  
M. Kochs ◽  
T. Habig ◽  
F. M. Mottaghy ◽  
...  
Keyword(s):  
Primary Endpoint ◽  
Bare Metal Stents ◽  
Target Lesion ◽  
Bare Metal Stent ◽  
Metal Stents ◽  
Bare Metal ◽  
Metal Stent ◽  
Post Intervention ◽  
Angiographic Restenosis

SummaryAims: We compared the intracoronary β-brachytherapy using a liquid rhenium-188 filled balloon with the slow-release, polymer-based, paclitaxel-eluting Taxus-Express stent for treatment of in-stent restenoses. Patients, methods: During the same study period, patients with restenoses in bare-metal stents were either treated with Taxus- Express stents (n = 50) or β-brachytherapy after successful angioplasty (n = 51). For brachytherapy 30 Gy in 0.5 mm tissue depth were administered. The irradiated segment exceeded the traumatized segment 7.5 mm on both sides. Primary endpoint was the minimal lumen diameter (MLD) at the target lesion at six months follow-up. Angiographic follow-up was available in 78% (n = 79/101) and clinical follow-up in all patients. Results: Baseline parameters did not differ statistically. The Taxus-Express stent resulted in a significantly larger MLD and a significantly lower percent diameter stenosis post intervention compared to β-brachytherapy, which both maintained until angiographic follow-up (primary endpoint 2.44 ± 0.74 mm versus 1.73 ± 0.74 mm, p <0.0001). Therefore, Taxus- Express stents were associated with a lower angiographic restenosis rate compared with β-brachytherapy, both for the target lesion (6.1% versus 17.4%) and the total segment (9.1% versus 23.9%). Moreover, use of Taxus-stent was associated with a clinical benefit based on a significantly lower MACE rate compared with β-brachytherapy (p <0.05). Conclusions: Paclitaxel-eluting Taxus- Express stents resulted in superior clinical and angiographic outcomes compared to intracoronary β-brachytherapy with a liquid 188Re filled balloon for treatment of restenosis within a bare-metal stent.

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