scholarly journals The Concentration-dependent Investigation of the Toxic Effects of the Anorectic Agent Sibutramine on the Electrical Activity of the Cardiomyocytes in Metabolic Syndrome Rat Heart

2021 ◽  
Vol 74 (2) ◽  
pp. 245-251
Author(s):  
Yusuf Olgar ◽  
Feyza Alyu ◽  
Yusuf Öztürk ◽  
Belma Turan
Keyword(s):  
Metabolic Syndrome ◽  
Electrical Activity ◽  
Rat Heart ◽  
Toxic Effects ◽  
Anorectic Agent

Toxic Effects of Palladium Compounds on the Isolated Rat Heart

2012 ◽  
Vol 8 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Tanja Peric ◽  
Vladimir Lj. Jakovljevic ◽  
Vladimir Zivkovic ◽  
Jelena Krkeljic ◽  
Zorica D. Petrovic ◽  
...  
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Toxic Effects ◽  
Palladium Compounds ◽  
Isolated Rat

scholarly journals Electrophysiological basis of metabolic-syndrome-induced cardiac dysfunction

2016 ◽  
Vol 94 (10) ◽  
pp. 1064-1073 ◽  
Author(s):  
Esma N. Okatan ◽  
Aysegul Toy Durak ◽  
Belma Turan
Keyword(s):  
Metabolic Syndrome ◽  
Rat Heart ◽  
Sodium Calcium Exchanger ◽  
Sodium Calcium ◽  
Pharmacological Targets ◽  
Intracellular Ca ◽  
Time Courses ◽  
High Sucrose ◽  
Sucrose Drinking

Myocardial contractility is controlled by intracellular Ca2+ cycling with the contribution of sarcoplasmic reticulum (SR). In this study, we aimed to investigate the role of altered SR function in defective regulation of intracellular Ca2+ levels in rats with metabolic syndrome (MetS) induced by a 16-week high-sucrose drinking-water diet. Electric-field stimulated transient intracellular Ca2+ changes in MetS cardiomyocytes exhibited significantly reduced amplitude (∼30%) and prolonged time courses (2-fold), as well as depressed SR Ca2+ loading (∼55%) with increased basal Ca2+ level. Consistent with these data, altered ryanodine receptor (RyR2) function and SERCA2a activity were found in MetS cardiomyocytes through Ca2+ spark measurements and caffeine application assay in a state in which sodium calcium exchanger was inhibited. Furthermore, tetracaine application assay results and hyperphosphorylated level of RyR2 also support the “leaky RyR2” hypothesis. Moreover, altered phosphorylation levels of phospholamban (PLN) support the depressed SERCA2a-activity thesis and these alterations in the phosphorylation of Ca2+-handling proteins are correlated with altered protein kinase and phosphatase activity in MetS cardiomyocytes. In conclusion, MetS-rat heart exhibits altered Ca2+ signaling largely due to altered SR function via changes in RyR2 and SERCA2a activity. These results point to RyR2 and SERCA2a as potential pharmacological targets for restoring intracellular Ca2+ homeostasis and, thereby, combatting dysfunction in MetS-rat heart.

scholarly journals Metabolic Syndrome Remodels Electrical Activity of the Sinoatrial Node and Produces Arrhythmias in Rats

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e76534 ◽  
Author(s):  
Alondra Albarado-Ibañez ◽  
José Everardo Avelino-Cruz ◽  
Myrian Velasco ◽  
Julián Torres-Jácome ◽  
Marcia Hiriart
Keyword(s):  
Metabolic Syndrome ◽  
Electrical Activity ◽  
Sinoatrial Node

scholarly journals The role of M3 receptors in regulation of electrical activity deteriorates in the rat heart during ageing

2021 ◽  
Author(s):  
Svetlana V. Tapilina ◽  
Alexandra D. Ivanova ◽  
Tatiana S. Filatova ◽  
Pavel A. Galenko-Yaroshevsky ◽  
Denis V. Abramochkin
Keyword(s):  
Electrical Activity ◽  
Rat Heart ◽  
M3 Receptors

scholarly journals The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents

2019 ◽  
Author(s):  
Thomas M McGrath ◽  
Eleanor Spreckley ◽  
Aina Fernandez Rodriguez ◽  
Carlo Viscomi ◽  
Amin Alamshah ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Feeding Behaviour ◽  
Light Period ◽  
Reduce Food Intake ◽  
Fed State ◽  
Behavioural Analysis ◽  
Ad Libitum ◽  
Anorectic Agent ◽  
Anorectic Drug ◽  
Stomach Emptying

AbstractBetter understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of rodent feeding at the bout level in order to perform quantitative behavioural analysis. Analysing the different effects on feeding behaviour of PYY3-36, lithium chloride, GLP-1 and leptin shows the precise behavioural changes caused by each anorectic agent. Our analysis demonstrates that the changes in feeding behaviour evoked by the anorectic agents investigated not mimic satiety. In thead libitumfed state during the light period, meal initiation is governed by complete stomach emptying, whereas in all other conditions there is a graduated response. We show how robust homeostatic control of feeding thwarts attempts to reduce food intake, and how this might be overcome.In silicoexperiments suggest that introducing a minimum intermeal interval or modulating gastric emptying can be as effective as anorectic drug administration.

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