scholarly journals Intramuscular Short-term ACTH Test for the Determination of Adrenal Function in Children: Safe, Effective and Reliable

2020 ◽  
Vol 12 (3) ◽  
pp. 241-247
Author(s):  
Elif Özsu ◽  
Zeynep Şıklar ◽  
Esra Bilici ◽  
Ayşegül Ceran ◽  
Rukiye Uyanık ◽  
...  
Keyword(s):  
Adrenal Function ◽  
Acth Test ◽  
Short Term

scholarly journals Usefulness of salivary cortisol as a marker of secondary adrenal insufficiency in paediatric patients

2021 ◽  
Vol 5 (1) ◽  
pp. 024-028
Author(s):  
Capdevila Laura ◽  
Borràs Ariadna ◽  
Berlanga Eugenio ◽  
Sánchez-Manubens Judith ◽  
Rivera Josefa ◽  
...  
Keyword(s):  
Adrenal Insufficiency ◽  
Salivary Cortisol ◽  
Low Dose ◽  
Adrenal Function ◽  
Prolonged Treatment ◽  
Acth Test ◽  
Paediatric Patients ◽  
Free Cortisol ◽  
Adrenal Disease

Background: The main cause of adrenal insufficiency (AI) in paediatric patients is prolonged treatment with corticosteroids. Determination of plasma cortisol (PC) during ACTH test is the most used adrenal function indicator in clinical practice. However, determination of salivary cortisol (SC), a simple test especially useful in children in order to avoid invasive procedures, can be used as an alternative technique for the diagnosis of adrenal disease. Methods: A two-year prospective study (January 2014-January 2016) in paediatric patients (2-18 years of age) treated with corticosteroids for more than fifteen days, who were investigated for suspected AI. Low-dose ACTH test was used to determine adrenal function and samples for SC and PC were obtained simultaneously in basal situation and during the test (at 30, 60 and 90 minutes). Results: 230 samples (118 PC-112 SC) of 30 studies belonging to 20 patients (4 males), mean age 10.93 years ± 3.69 SD. Pearson’s correlation coefficient showed a positive correlation between PC and SC (r = 0.618, p < 0.001). All the studies with some determination of PC higher than 18 μg/dL (n = 8) had a SC peak higher than 0.61 μg/dL with a specificity of 66.67% and a sensitivity of 93.94% (ROC analysis). Conclusion: Measurement of SC is a less invasive, easier and quicker test than PC to measure plasma free cortisol levels. In our study, a SC peak in low-dose ACTH test higher than 0.61 μg/dL was able to discriminate patients without AI, and proved to be a useful tool in the initial evaluation of children with suspected AI.

DETERMINATION OF BLOOD CORTICOIDS USING THE IN VITRO RESIN UPTAKE OF 3H-PREDNISOLONE

1968 ◽  
Vol 57 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Hironori Nakajima ◽  
Mitsunori Murala ◽  
Masumitsu Nakata ◽  
Takeshi Naruse ◽  
Seiji Kubo
Keyword(s):  
Thyroid Function Test ◽  
Normal Subjects ◽  
Adrenal Function ◽  
Function Test ◽  
Before And After ◽  
Adrenal Response ◽  
Suppression Test

ABSTRACT The in vitro resin uptake of 3H-prednisolone was used for the determination of blood cortisol after addition of radioactive prednisolone followed by Amberlite CG 400 Type 1 to the test serum, and incubation of the mixture. The radioactivity of the supernatant was compared before and after the addition of the resin. The principle of this method is similar to that of the 131I-triiodothyronine resin uptake for the thyroid function test. The tests for the specificity, reproducibility and sensitivity gave satisfactory results. The mean basal value ± SD of the 3H-prednisolone resin uptake was 35.3 ± 9.2% in normal subjects, and 27.1 ± 4.8% in pregnant women. This method was valid in various adrenal function tests, i. e. the adrenal circadian rhythm, corticotrophin (ACTH) test, dexamethasone suppression test and the adrenal response to lysine-8-vasopressin. It proved to be a sensitive indicator of the adrenal function. These results suggest that this method should be useful for a routine adrenal function test.

Determination of allostatic load dynamics in the assessment of adaptation in temporary workers in the Arctic

2020 ◽  
pp. 547-548
Author(s):  
O. Yu. Atkov ◽  
S. G. Gorokhova
Keyword(s):  
Body Mass Index ◽  
Glucose Level ◽  
Shift Work ◽  
Allostatic Load ◽  
The Arctic ◽  
Temporary Workers ◽  
Short Term ◽  
Short Term Adaptation ◽  
The Individual

The individual dynamics of the allostatic load index was revealed mainly due to changes in the glucose level, body mass index, which makes it applicable for assessing the short-term adaptation to the stay in the conditions of shift work

Short-Term Determination of Carcinogenic Aromatic Hydrocarbons

1960 ◽  
Vol 32 (2) ◽  
pp. 295-296 ◽  
Author(s):  
Dietrich. Hoffmann ◽  
E. L. Wynder
Keyword(s):  
Aromatic Hydrocarbons ◽  
Short Term

Quantifying Office Productivity: An Ergonomic Framework

1998 ◽  
Vol 42 (13) ◽  
pp. 974-978 ◽  
Author(s):  
Alan Hedge
Keyword(s):  
Life Cycle ◽  
Duty Cycle ◽  
Office Workers ◽  
Short Term ◽  
Task Time ◽  
Ergonomic Interventions ◽  
The Impact

An ergonomic framework for conceptualizing and measuring office productivity is described. This framework is based on the the analysis of task time, posture and sequence, and the subsequent the determination of the most appropriate pace, posture, and activities for any office job. The framework assesses various measures of pace, proficiency, and posture that currently can be readily assessed by ergonomists, and it uses these measures to quantify the short-term duty cycle productivity (DCP) and in the longer-term life-cycle productivity (LCP) of office workers. The approach that will be described allows companies to evaluate the impact of ergonomic interventions on the productivity of their workers. The benefits of this ergonomic approach to assessing productivity are discussed.

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