scholarly journals Systematic review, meta-analysis and statistical analysis of laparoscopic supracervical hysterectomy vs endometrial ablation

Author(s):  
Greg J. Marchand ◽  
Ali Azadi ◽  
Katelyn Sainz ◽  
Ahmed Masoud ◽  
Sienna Anderson ◽  
...  
2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
A A Tahir ◽  
K M Ali ◽  
A U Khan ◽  
S Kamal ◽  
A Hussain ◽  
...  

Abstract Introduction Diverticular disease is a common health problem with a wide clinical spectrum. About 75% of the patients would have uncomplicated diverticulitis. Cornerstones of treatment are antibiotics, analgesia, and dietary advice. Recent evidence has shown that its treatment is controversial, questioning the use of antibiotics. Aim is to assess the role of antibiotics in the treatment of acute uncomplicated diverticulitis. Method This is a systematic review and Meta-analysis. Literature review of the available studies was conducted using search engines like Pubmed, Medline, Embase, Google Scholar, and Cochrane databases. Statistical analysis was conducted using RevMan5.4. Results Out of 1754 records 1324 were duplicates, 430 studies were screened. 395 were further excluded.35 full text articles were assessed and in the final review 10 studies were included. PRISMA guidelines were used. Pooled OR for recurrence = 0.92 (95% CI = 0.74 to 1.13). Pooled OR for Hospital stay= -0.66 (95% CI= -1.12 to -0.21). Pooled OR for complications = 1.06 (95% CI = 0.69 to 1.64). Pooled OR for treatment failure= 1.24 (95% CI = 0.90-1.69). Conclusions We conclude that from the available evidence antibiotics have no role in reducing recurrence, complications, treatment failure, and duration of hospital stay in acute uncomplicated diverticulitis.


2017 ◽  
Author(s):  
Fernanda Stumpf Tonin ◽  
Helena Borba ◽  
Astrid Wiens ◽  
Fernando Fernandez-Llimos ◽  
Roberto Pontarolo

Author(s):  
Rania M. Magadmi

Aims: Globally the focus is towards finding an effective treatment for COVID-19 patients in order to suppress the spread of this pandemic disease. An antiviral combination of lopinavir-ritonavir is considered to be effective in treating COVID-19 patients. Therefore, the present study aims to assess the clinical improvements of lopinavir-ritonavir in COVID-19 patients. Study Design: a systematic review study was conducted and articles published since December 2019 were included. The statistical analysis of quantitative data was performed using Review Manager (RevMan) to generate forest plots. Results: The study showed that there was no significant difference in COVID-19 patients treated with lopinavir-ritonavir or in combination with anti-viral therapy or other conventional methods. Conclusion: the use of lopinavir-ritonavir resulted in greater adverse consequences among COVID-19 patients. It further recommends conducting meta-analysis studies with a greater number of studies to highlight the clinical improvement associated with the use of Lopinavir-ritonavir.


2013 ◽  
Vol 122 (2) ◽  
pp. 124-127 ◽  
Author(s):  
Kazem Nouri ◽  
Maurus Demmel ◽  
Ulrike Greilberger ◽  
Eva-Maria Fischer ◽  
Rudolf Seemann ◽  
...  

2018 ◽  
pp. 251-253 ◽  
Author(s):  
Herney Andrés García-Perdomo

Systematic reviews (SR) have been important tools for determining the magnitude of an effect, with appropriate methodology, rigor and scientific quality. This epidemiologic design was developed to conduct an exhaustive, systematic and explicit assessment of the literature, based on a clearly research question, an explicit methodology, a critical appraisal using a variety of tools and a qualitative summary of the evidence. On the other hand, the meta-analysis (MA), is the statistical analysis used in the synthesis of the evidence at the end of a very well performed systematic review. It compares head to head interventions, however nowadays, we have another tool to perform indirect or mixed comparisons (Network meta-analysis). This new statistical tool evaluates the effectiveness when comparing different treatments with similar characteristics, which have not been directly compared in a study. Unlike the traditional meta-analysis, this new tool compares the results of different studies that have a point or a common intervention without a direct comparison.


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