The Role of Fusion Technique of Computed Tomography and Non-echo-planar Diffusion-weighted Imaging in the Evaluation of Surgical Localization of Cholesteatoma

Abstract Aim To determine the role of diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) values in differentiating benign and malignant orbital masses. Materials and Methods After obtaining institutional ethical board approval and informed consent from all patients, an observational study was done for a period of 24 months in the radiology department of a tertiary care hospital in South India. Conventional magnetic resonance imaging and DWI using a 3T scanner was done for all patients with suspected orbital mass lesion. ADC value and clinicohistopathological correlation were studied for every patient. Chi-square test was used to compare the signal characteristics of DWI and ADC maps between benign and malignant lesions. A comparison of mean ADC values for benign and malignant masses was performed using Student’s t-test for independent samples. The cut-off value for ADC was obtained using the receiver operating characteristic (ROC) curve. Results Of 44 patients with orbital lesions, 70% were benign and 30% were malignant. There was a significant difference in the mean ADC values of benign and malignant orbital masses. Using ROC curve analysis, an optimal ADC threshold of 1.26 × 10−3 mm2/s was calculated for the prediction of malignancy with 100% sensitivity, 80.65% specificity, and 86.36% accuracy (95% confidence interval: 0.872, 1.00, p < 0.0001). Two ADC thresholds were used to characterize the orbital masses with more than 90% confidence. Conclusion Quantitative assessment of ADC is a useful noninvasive diagnostic tool for differentiating benign and malignant orbital masses. Malignant orbital lesions demonstrate significantly lower ADC values as compared with benign lesions.

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Comparison between turbo spin-echo and echo planar diffusion-weighted imaging of the female pelvis with 3T MRI

Acta Radiologica Open ◽

10.1177/2058460121994737 ◽

2021 ◽

Vol 10 (2) ◽

pp. 205846012199473

Author(s):

Takeshi Yoshizako ◽

Rika Yoshida ◽

Hiroya Asou ◽

Megumi Nakamura ◽

Hajime Kitagaki

Keyword(s):

Image Quality ◽

Diffusion Weighted Imaging ◽

Spin Echo ◽

Turbo Spin Echo ◽

Female Pelvis ◽

3T Mri ◽

Turbo Spin ◽

Diffusion Weighted ◽

Adc Values ◽

Echo Planar

Background Echo-planar imaging (EPI)-diffusion-weighted imaging (DWI) may take unclear image affected by susceptibility, geometric distortions and chemical shift artifacts. Purpose To compare the image quality and usefulness of EPI-DWI and turbo spin echo (TSE)-DWI in female patients who required imaging of the pelvis. Material and Methods All 57 patients were examined with a 3.0-T MR scanner. Both TSE- and EPI-DWI were performed with b values of 0 and 1000 s/mm2. We compared geometric distortion, the contrast ratio (CR) of the myometrium to the muscle and the apparent diffusion coefficient (ADC) values for the myometrium and lesion. Two radiologists scored the TSE- and EPI-DWI of each patient for qualitative evaluation. Results The mean percent distortion was significantly smaller with TSE- than EPI-DWI ( p = 0.00). The CR was significantly higher with TSE- than EPI-DWI ( p = 0.003). There was a significant difference in the ADC value for the uterus and lesions between the EPI- and TSE-DWI ( p < 0.05). Finally, the ADC values of cancer were significantly different from those for the uterus and benign with both the two sequences ( p < 0.05). The scores for ghosting artifacts were higher with TSE- than EPI-DWI ( p = 0.019). But there were no significant differences between TSE- and EPI-DWI with regard to image contrast and overall image quality. Conclusion TSE-DWI on the female pelvis by 3T MRI produces less distortion and higher CR than EPI-DWI, but there is no difference in contrast and image quality.

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Role of quantitative diffusion weighted imaging in characterization of breast masses

The Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1016/j.ejrnm.2015.05.006 ◽

2015 ◽

Vol 46 (3) ◽

pp. 805-810 ◽

Cited By ~ 5

Author(s):

Yosra Abdelzaher Ibrahim ◽

Lobna Habib ◽

Ahmed Deif

Keyword(s):

Diffusion Weighted Imaging ◽

Breast Masses ◽

Diffusion Weighted

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Role of Diffusion Weighted Imaging in Differentiating Benign from Pathological Vertebral Compression

QJM ◽

10.1093/qjmed/hcab106.010 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Faten Mohammed Mahmoud Kamel ◽

Hazem Ibrahim Abdel Rahman ◽

Amany Sayed Khaleel Ahmed Elkhayat

Keyword(s):

Vertebral Fractures ◽

Diffusion Weighted Imaging ◽

Laboratory Evaluation ◽

Vertebral Collapse ◽

Adc Value ◽

Conventional Mri ◽

Diffusion Weighted ◽

Significant Difference

Abstract Background Vertebral collapse is a common problem due to benign conditions (trauma, infection, osteoporosis) or malignant process. And although the spine is the most common site of bone metastases (39% of bony metastases in patients with primary neoplasms) benign vertebral fractures due to osteopenia occur in one third of cancer patients, making it essential to determine whether the cause of vertebral collapse is benign or malignant. Aim of the Work To establish the role of DWI in differentiating benign from pathologic vertebral fractures using ADC values in comparison with histopathology report /laboratory evaluation and clinical follow-up. Patients and Methods A cross sectional study is approved by the ethics review board of Ain Shams University Hospital (Al Demerdash). All patients provided informed consent for the MR imaging examinations and for inclusion of their data in this analysis. From April 2020 to october 2020, 25 cases with previous imaging with vertebral compression underwent conventional MRI study on the affected region. Diffusion weighted imaging and ADC was added. Results We performed DWI using maximum b-values 600, and quantitative analysis, named apparent diffusion coefficient (ADC). We correlated the ADC number to histopathology, laboratory finding and clinical follow up. In our study there was significant difference (p < 0.04) between DWI of the benign and malignant groups. Also the ADC value showed significant difference <0.001. The mean ADCs of benign VCFs were higher significantly than those of pathological fractures. Conclusion DWI with ADC value was helpful when added to conventional MRI to differentiate benign from pathological (malignant) vertebral compression. It should be a routine sequence in patients with vertebral compression fractures for accurate diagnosis and successful management also can decrease no of biopsies.

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