Changes in the humoral immune responses after chemotherapy in single and co-infected individuals with Schisosoma haematobuim and Plasmodium falciparum

2010 ◽  
Vol 52 (9-12) ◽  
Author(s):  
S Zinyowera ◽  
CE Muchaneta-Kabara ◽  
F Mutapi ◽  
N Midzi ◽  
P.D Mdlovu ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Immune Responses ◽  
Humoral Immune ◽  
Humoral Immune Responses

scholarly journals How to induce protective humoral immunity against Plasmodium falciparum circumsporozoite protein

2022 ◽  
Vol 219 (2) ◽  
Author(s):  
Ilka Wahl ◽  
Hedda Wardemann
Keyword(s):  
Plasmodium Falciparum ◽  
Immune Responses ◽  
Vaccine Efficacy ◽  
Circumsporozoite Protein ◽  
Surface Proteins ◽  
Humoral Immune ◽  
Cell Responses ◽  
Humoral Immune Responses ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum

The induction of protective humoral immune responses against sporozoite surface proteins of the human parasite Plasmodium falciparum (Pf) is a prime goal in the development of a preerythrocytic malaria vaccine. The most promising antibody target is circumsporozoite protein (CSP). Although PfCSP induces strong humoral immune responses upon vaccination, vaccine efficacy is overall limited and not durable. Here, we review recent efforts to gain a better molecular and cellular understanding of anti-PfCSP B cell responses in humans and discuss ways to overcome limitations in the induction of stable titers of high-affinity antibodies that might help to increase vaccine efficacy and promote long-lived protection.

Humoral immune responses in Gambians to Pfs16, an immunodominant, Plasmodium falciparum integral membrane protein

1996 ◽  
Vol 18 (10) ◽  
pp. 527-533 ◽  
Author(s):  
D.A. BAKER ◽  
C.J. DRAKELEY ◽  
C.S.L. ONG ◽  
A.G‐M.I. LULAT ◽  
B.M. GREENWOOD ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Membrane Protein ◽  
Immune Responses ◽  
Integral Membrane Protein ◽  
Humoral Immune ◽  
Humoral Immune Responses
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