Naturally acquired cellular and humoral immune responses to the major merozoite surface antigen (Pf MSP1) of Plasmodium falciparum are associated with reduced malaria morbidity

1992 ◽  
Vol 14 (3) ◽  
pp. 321-337 ◽  
Author(s):  
E. M. RILEY ◽  
S. J. ALLEN ◽  
J. G. WHEELER ◽  
M. J. BLACKMAN ◽  
S. BENNETT ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Immune Responses ◽  
Surface Antigen ◽  
Humoral Immune ◽  
Malaria Morbidity ◽  
Humoral Immune Responses ◽  
Merozoite Surface Antigen

scholarly journals How to induce protective humoral immunity against Plasmodium falciparum circumsporozoite protein

2022 ◽  
Vol 219 (2) ◽  
Author(s):  
Ilka Wahl ◽  
Hedda Wardemann
Keyword(s):  
Plasmodium Falciparum ◽  
Immune Responses ◽  
Vaccine Efficacy ◽  
Circumsporozoite Protein ◽  
Surface Proteins ◽  
Humoral Immune ◽  
Cell Responses ◽  
Humoral Immune Responses ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum

The induction of protective humoral immune responses against sporozoite surface proteins of the human parasite Plasmodium falciparum (Pf) is a prime goal in the development of a preerythrocytic malaria vaccine. The most promising antibody target is circumsporozoite protein (CSP). Although PfCSP induces strong humoral immune responses upon vaccination, vaccine efficacy is overall limited and not durable. Here, we review recent efforts to gain a better molecular and cellular understanding of anti-PfCSP B cell responses in humans and discuss ways to overcome limitations in the induction of stable titers of high-affinity antibodies that might help to increase vaccine efficacy and promote long-lived protection.

scholarly journals A Recombinant Measles Virus Expressing Hepatitis B Virus Surface Antigen Induces Humoral Immune Responses in Genetically Modified Mice

1999 ◽  
Vol 73 (6) ◽  
pp. 4823-4828 ◽  
Author(s):  
Mahender Singh ◽  
Roberto Cattaneo ◽  
Martin A. Billeter
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Responses ◽  
Surface Antigen ◽  
Measles Virus ◽  
Genetically Modified ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
B Virus ◽  
Genetically Modified Mice

ABSTRACT It has been shown previously that measles virus (MV) can be successfully used to express foreign proteins (M. Singh and M. A. Billeter, J. Gen. Virol. 80:101–106, 1998). To develop an inexpensive MV-based vaccine, we generated recombinant MVs that produce structural proteins of hepatitis B virus (HBV). A recombinant virus that expressed the HBV small surface antigen (HBsAg) was analyzed in terms of its replication characteristics, its genetic stability in cell culture, and its immunogenic potential in genetically modified mice. Although this virus showed a progression of replication slightly slower than that of the parental MV, it appeared to stably maintain the added genetic information; it uniformly expressed the appropriately glycosylated HBsAg after 10 serial passages. Genetically modified mice inoculated with this recombinant MV produced humoral immune responses against both HBsAg and MV proteins.

Humoral immune responses in Gambians to Pfs16, an immunodominant, Plasmodium falciparum integral membrane protein

1996 ◽  
Vol 18 (10) ◽  
pp. 527-533 ◽  
Author(s):  
D.A. BAKER ◽  
C.J. DRAKELEY ◽  
C.S.L. ONG ◽  
A.G‐M.I. LULAT ◽  
B.M. GREENWOOD ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Membrane Protein ◽  
Immune Responses ◽  
Integral Membrane Protein ◽  
Humoral Immune ◽  
Humoral Immune Responses
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