scholarly journals Clinical presentation of Parkinson's disease among Sudanese patients

2009 ◽  
Vol 4 (3) ◽  
Author(s):  
K Khalid ◽  
A Hussien ◽  
K Khalafela ◽  
A Yonis ◽  
AA Eltoum ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Presentation

scholarly journals Emergencies and critical issues in Parkinson’s disease

2019 ◽  
pp. practneurol-2018-002075 ◽  
Author(s):  
Cristina Simonet ◽  
Eduardo Tolosa ◽  
Ana Camara ◽  
Francesc Valldeoriola
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Presentation ◽  
Early Recognition ◽  
Medical Intervention ◽  
Disease Course ◽  
Precipitating Factors ◽  
Critical Issues ◽  
Prompt Attention ◽  
Disease Specialist

Complications from Parkinson’s disease may develop over the disease course, sometimes unexpectedly, and require prompt or even urgent medical intervention. The most common are associated with aggravation of motor symptoms; serious non-motor complications, such as psychosis, orthostatic hypotension or sleep attacks, also occur. Here we review such complications, their clinical presentation, precipitating factors and management, including those related to using device-aided therapies. Early recognition and prompt attention to these critical situations is challenging, even for the Parkinson’s disease specialist, but is essential to prevent serious problems.

scholarly journals Clinical Presentation of Parkinson’s Disease: Experience of using Movement Disorder Society Clinical Diagnostic Criteria for Parkinson’s Disease

2021 ◽  
pp. 183-188
Author(s):  
Muhammad Rezeul Huq ◽  
M. A. Hannan ◽  
Md. Ahsan Habib ◽  
Ahad Mahmud Khan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Movement Disorder ◽  
Diagnostic Criteria ◽  
Clinical Presentation ◽  
Neurodegenerative Disorder ◽  
Motor Symptom ◽  
Clinical Diagnostic ◽  
Movement Disorder Society ◽  
Clinical Diagnostic Criteria

Aims: Parkinson’s disease (PD) is a common neurodegenerative disorder. As no definite diagnostic tests are available, diagnosis is done mostly clinically. UK Brain Bank criteria is commonly used globally for that purpose. In this study we used Movement Disorder Society (MDS) Clinical Diagnostic Criteria to diagnose PD and document the clinical presentations. Study design: Descriptive cross-sectional study. Methodology: This study was carried out in the department of neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from May 2018 to April 2019. Total 42 patients (4 clinically established and 38 clinically probable PD) were enrolled as study population according to Movement Disorder Society (MDS) Clinical Diagnostic Criteria - 2015 for PD. Their patterns of clinical presentation were recorded. Results: Among the PD patients, 31 were male and 11 were female. Mean age of all patients was 59.43 ± 11.34 years. The most common presenting feature was tremulous movement (90.5%) followed by slowness of movement (40.5%). Only 9% patients had early onset PD. All patients had history of positive response to dopaminergic therapy with documented resting tremor in 95.2%, and end-of-dose wearing off in 75.6%. Constipation was the commonest (69%) non motor symptom followed by sleep dysfunction (64.3%) & depression (50%). On examination- 100% patients had bradykinesia, 97.6% rest tremor, 95.2% rigidity, 21.4% mild dementia and 4.8% moderate dementia. Also 26.2% patients were found to have postural hypotension. 4 patients had red flag features- urinary retention was found in three patients and one patient suffered from recurrent early fall. Conclusion: MDS Clinical Diagnostic Criteria   help in accurate diagnosis of PD and include more clinical features which will help in formulating management plan.

Neuropsychiatric manifestations of Parkinson’s disease

2016 ◽  
Vol 24 (6) ◽  
pp. 529-533 ◽  
Author(s):  
Rosa M Molina Ruiz ◽  
Andrew H Evans ◽  
Dennis Velakoulis ◽  
Jeffrey CL Looi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Presentation ◽  
Early Recognition ◽  
Neuropsychiatric Symptoms ◽  
Systematic Search ◽  
Neuropsychiatric Manifestations

Objective: This clinical update review focuses on the classification and description of common neuropsychiatric manifestations in Parkinson’s disease (PD). Method: We conducted a systematic search of the literature using Pubmed and selected the most recent and relevant papers for this review. Results: Neuropsychiatric manifestations in PD are are very frequent and may arise from an abnormal psychopathological response to the disease, neurobiological changes related to the disease itself, complications of treatments or a combination of all of these. Conclusions: Neuropsychiatric symptoms may precede the motor clinical presentation of PD. Early recognition is essential.

Parkinson's disease in Ireland: Clinical presentation and genetic heterogeneity in patients with parkin mutations

2004 ◽  
Vol 19 (6) ◽  
pp. 677-681 ◽  
Author(s):  
Joseph Wiley ◽  
Timothy Lynch ◽  
Sarah Lincoln ◽  
Lisa Skipper ◽  
Mary Hulihan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Genetic Heterogeneity ◽  
Clinical Presentation

Prevalence and Phenotypic Spectrum of PINK1 Mutations in Parkinson’s Disease

US Neurology ◽  
2009 ◽  
Vol 05 (01) ◽  
pp. 34 ◽  
Author(s):  
Alessandro Ferraris ◽  
Enza Maria Valente ◽  
Anna Rita Bentivoglio ◽  
◽  
◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Autosomal Recessive ◽  
Autosomal Dominant ◽  
Clinical Presentation ◽  
Rare Variants ◽  
Age At Onset ◽  
Early Age ◽  
Slow Disease Progression ◽  
Phenotypic Spectrum

Several genes have been identified as causative of autosomal dominant or recessive forms of Parkinson’s disease (PD). Bi-allelic mutations in the PTEN-induced putative kinase 1 (PINK1) gene represent the second most frequent cause of autosomal recessive parkinsonism (ARP) after PARK2/Parkin. The typicalPINK1-associated phenotype is characterized by early age at onset, slow disease progression, and excellent and sustained response to levodopa, but in rare cases the clinical presentation can be indistinguishable from that of sporadic PD. Single heterozygous rare variants in thePINK1gene, as well as in other ARP genes, have been frequently detected both in parkinsonian patients and in healthy controls. Although their pathogenetic role is still debated, these variants have been suggested to act as minor risk factors for developing PD.

A potential case of remission of Parkinson’s disease

2016 ◽  
Vol 13 (3) ◽  
Author(s):  
Karishma Smart ◽  
Raymon Durso ◽  
Jonathan Morgan ◽  
Patrick McNamara
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Presentation ◽  
Positive Response ◽  
Hand Tremor ◽  
Left Hand ◽  
Potential Case ◽  
History Of ◽  
Stooped Posture ◽  
Symptoms And Signs

AbstractWe present the case of a 78-year-old male who, 16 years ago, was diagnosed with Parkinson’s disease (PD) by a neurologist. He initially presented with left-hand tremor, stooped posture, shuffling gait, and frequent falls, which eventually progressed to bilateral motor symptoms after 3 years. Since 2012, his symptoms and signs have almost completely remitted, and he has been off all pharmacotherapy for that time. The accuracy of the initial PD diagnosis is supported by an appropriate clinical presentation, history of positive response to Sinemet, and an abnormal SPECT DaT scan; thus this case suggests the possibility of remission of symptoms in some patients. We propose that the patient’s long history of meditation practice may have been one contributing factor of this improvement as meditation has been shown to release dopamine in the striatum.

Prevalence and Phenotypic Spectrum of PINK1 Mutations in Parkinson’s Disease

2009 ◽  
Vol 4 (1) ◽  
pp. 40 ◽  
Author(s):  
Alessandro Ferraris ◽  
Enza Maria Valente ◽  
Anna Rita Bentivoglio ◽  
◽  
◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Autosomal Recessive ◽  
Autosomal Dominant ◽  
Clinical Presentation ◽  
Rare Variants ◽  
Age At Onset ◽  
Slow Disease Progression ◽  
Phenotypic Spectrum ◽  
Phosphatase And Tensin Homologue

Several genes have been identified as causative of autosomal dominant or recessive forms of Parkinson’s disease (PD). Bi-allelic mutations in the phosphatase and tensin homologue (PTEN)-induced putative kinase 1 (PINK1) gene represent the second most frequent cause of autosomal recessive parkinsonism (ARP) after PARK2/Parkin. The typicalPINK1-associated phenotype is characterised by early age at onset, slow disease progression and excellent and sustained response to levodopa, but in rare cases the clinical presentation can be indistinguishable from that of sporadic PD. Single heterozygous rare variants in thePINK1gene, as well as in other ARP genes, have been frequently detected both in parkinsonian patients and in healthy controls. Although their pathogenetic role is still debated, these variants have been suggested to act as minor risk factors for developing PD.

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