Human mesenchymal stem cells and multilineage differentiation to mesoderm lineages

2004 ◽  
pp. 83-100
Author(s):  
Virginie Sottile ◽  
Jim McWhir
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Multilineage Differentiation

Noninvasive MRI and multilineage differentiation capability of ferritin-transduced human mesenchymal stem cells

2014 ◽  
Vol 28 (2) ◽  
pp. 168-179 ◽  
Author(s):  
Hoe Suk Kim ◽  
Jisu Woo ◽  
YoonSeok Choi ◽  
Eun Hye Hwang ◽  
Sul Ki Choi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Multilineage Differentiation

scholarly journals Characterization of Human Mesenchymal Stem Cells from Different Tissues and Their Membrane Encasement for Prospective Transplantation Therapies

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Eva Schmelzer ◽  
Daniel T. McKeel ◽  
Jörg C. Gerlach
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factors ◽  
Cell Fusion ◽  
Human Mesenchymal Stem Cells ◽  
Surface Markers ◽  
Multilineage Differentiation ◽  
Differentiation Potential ◽  
Donor Cells ◽  
Different Tissues

Human mesenchymal stem cells can be isolated from various organs and are in studies on therapeutic cell transplantation. Positive clinical outcomes of transplantations have been attributed to both the secretion of cytokines and growth factors as well as the fusion of donor cells with that of the host. We compared human mesenchymal stem cells from six different tissues for their transplantation-relevant potential. Furthermore, for prospective allogenic transplantation we developed a semipermeable hollow-fiber membrane enclosure, which would prevent cell fusion, would provide an immune barrier, and would allow for easy removal of donor cells from patients after recovery. We investigated human mesenchymal stem cells from adipose tissue, amniotic tissue, bone marrow, chorionic tissue, liver, and umbilical cord. We compared their multilineage differentiation potential, secretion of growth factors, and the expression of genes and surface markers. We found that although the expression of typical mesenchymal stem cell-associated gene THY1 and surface markers CD90 and CD73 were mostly similar between mesenchymal stem cells from different donor sites, their expression of lineage-specific genes, secretion of growth factors, multilineage differentiation potential, and other surface markers were considerably different. The encasement of mesenchymal stem cells in fibers affected the various mesenchymal stem cells differently depending on their donor site. Conclusively, mesenchymal stem cells isolated from different tissues were not equal, which should be taken into consideration when deciding for optimal sourcing for therapeutic transplantation. The encasement of mesenchymal stem cells into semipermeable membranes could provide a physical immune barrier, preventing cell fusion.

Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold

Biomaterials ◽  
2005 ◽  
Vol 26 (25) ◽  
pp. 5158-5166 ◽  
Author(s):  
Wan-Ju Li ◽  
Richard Tuli ◽  
Xiaoxue Huang ◽  
Patrice Laquerriere ◽  
Rocky S. Tuan
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Three Dimensional ◽  
Human Mesenchymal Stem Cells ◽  
Nanofibrous Scaffold ◽  
Multilineage Differentiation

Differential Effects of Small Molecule WNT Agonists on the Multilineage Differentiation Capacity of Human Mesenchymal Stem Cells

2016 ◽  
Vol 22 (21-22) ◽  
pp. 1264-1273 ◽  
Author(s):  
Roberto Narcisi ◽  
Ozan H. Arikan ◽  
Johannes Lehmann ◽  
Derk ten Berge ◽  
Gerjo J.V.M. van Osch
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Small Molecule ◽  
Human Mesenchymal Stem Cells ◽  
Multilineage Differentiation ◽  
Differentiation Capacity ◽  
Differential Effects

scholarly journals Human Mesenchymal Stem Cells Retain Multilineage Differentiation Capacity Including Neural Marker Expression after Extended In Vitro Expansion

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137255 ◽  
Author(s):  
Rachel K. Okolicsanyi ◽  
Emily T. Camilleri ◽  
Lotta E Oikari ◽  
Chieh Yu ◽  
Simon M. Cool ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Multilineage Differentiation ◽  
Differentiation Capacity ◽  
In Vitro Expansion ◽  
Neural Marker ◽  
Marker Expression

Proliferation and multi-differentiation potentials of human mesenchymal stem cells on thermoresponsive PDMS surfaces grafted with PNIPAAm

2010 ◽  
Vol 30 (6) ◽  
pp. 455-455 ◽  
Author(s):  
Dongyan Shi ◽  
Dan Ma ◽  
Feiqing Dong ◽  
Chen Zong ◽  
Liyue Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

The Effect of Link N on the Differentiation of Human Mesenchymal Stem Cells

2012 ◽  
Vol 2 (1_suppl) ◽  
pp. s-0032-1320001-s-0032-1320001
Author(s):  
F. Mwale ◽  
H. T. Wang ◽  
L. Haglund ◽  
P. J. Roughley ◽  
J. Antoniou
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

Generation of human mesenchymal stem cells lacking diabetoporosity-associated miRNAs using CRISPR/Cas9

2020 ◽  
Author(s):  
I Foessl ◽  
A Groselj-Strele ◽  
JC Piswanger-Sölkner ◽  
H Dobnig ◽  
A Fahrleitner-Pammer ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells
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