The authors have conducted a research program on the interface between psychophysiology and cognitive therapy for a number of years. Here, they describe a recent study concerning schizophrenia and cluster A personality disorders (paranoid, schizoid, schizotypal). They studied some psychophysiological parameters such as evoked brain potentials and electrodermal activity as well as other aspects concerning parenting. This last topic was investigated by means of the parental bonding instrument. Three groups participated in this study: 10 schizophrenic patients, 10 patients affected by cluster A personality disorders (5 paranoid, 1 schizoid and 4 schizotypal) and 10 controls. The authors found some specific, different patterns among the three groups concerning arousal, human information processing and attachment. These results are discussed in the light of their implications for cognitive therapy. The authors give different guidelines for cognitive therapy of schizophrenic patients and cluster A personality disorder.