Ocular Drug Transfer Following Systemic Drug Administration

2021 ◽  
pp. 109-133
Author(s):  
Nelson L. Jumbe ◽  
Michael H. Miller
Keyword(s):  
Drug Administration ◽  
Drug Transfer ◽  
Systemic Drug

scholarly journals MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEMS CONTAINING POLYSACCHARIDES

2020 ◽  
Vol 54 (9-10) ◽  
pp. 889-902
Author(s):  
IRINA M. PELIN ◽  
DANA M. SUFLET
Keyword(s):  
Drug Delivery ◽  
Drug Administration ◽  
Drug Delivery Systems ◽  
Enzymatic Degradation ◽  
Low Cost ◽  
Hepatic Metabolism ◽  
Drug Action ◽  
Delivery Systems ◽  
Buccal Drug Delivery ◽  
Systemic Drug

The buccal mucosa is an attractive site for drug administration as it allows avoiding the enzymatic degradation of the drug in the gastrointestinal tract and its hepatic metabolism. For buccal administration, different drug delivery systems with controlled mucoadhesion have been developed and some of them are available on the market. Mucoadhesion makes it possible to obtain prolonged, local or systemic drug action, and this process is highly influenced by several factors, among which, the reactivity of macromolecules from the formulations is very important. Polysaccharides are increasingly studied due to their abundance in natural resources, low-cost availability and easy chemical modification, but also due to their biocompatibility, biodegradability and non-toxicity properties. This review briefly describes the advantages of using the buccal route of drug administration, the influencing factors that are taken into account for obtaining mucoadhesive dosage forms, and the main polysaccharides and their derivatives used for fabrication of buccal drug delivery systems.

scholarly journals Evaluating Medication Use in Pregnancy and Lactation: What Every Pharmacist Should Know

2013 ◽  
Vol 18 (3) ◽  
pp. 247-258 ◽  
Author(s):  
Betsy Walters Burkey ◽  
Amy P. Holmes
Keyword(s):  
Breast Milk ◽  
Drug Administration ◽  
Rating Scales ◽  
Food And Drug Administration ◽  
Medication Use ◽  
Drug Transfer ◽  
Drug Classes ◽  
Pregnancy And Lactation ◽  
In Pregnancy

As a pharmacist, being asked to give advice about medication use during pregnancy or lactation can be daunting. This article reviews the principles of drug transfer across the placenta, into breast milk, and reviews the rating scales and different resources available. The Food and Drug Administration classification scale is reviewed and the upcoming changes are explained, along with recent labeling changes for specific medications or drug classes when appropriate. This article provides the pharmacist with a practical set of tools to review the information available and assess the risks of treating or withholding a medication for mother and infant.

scholarly journals Miniaturized neural system for chronic, local intracerebral drug delivery

2018 ◽  
Vol 10 (425) ◽  
pp. eaan2742 ◽  
Author(s):  
Canan Dagdeviren ◽  
Khalil B. Ramadi ◽  
Pauline Joe ◽  
Kevin Spencer ◽  
Helen N. Schwerdt ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Administration ◽  
Small Volume ◽  
Drug Distribution ◽  
Neural System ◽  
Small Rodent ◽  
Dynamic Adjustment ◽  
Increased Risk ◽  
Pharmacologic Treatments ◽  
Systemic Drug

Recent advances in medications for neurodegenerative disorders are expanding opportunities for improving the debilitating symptoms suffered by patients. Existing pharmacologic treatments, however, often rely on systemic drug administration, which result in broad drug distribution and consequent increased risk for toxicity. Given that many key neural circuitries have sub–cubic millimeter volumes and cell-specific characteristics, small-volume drug administration into affected brain areas with minimal diffusion and leakage is essential. We report the development of an implantable, remotely controllable, miniaturized neural drug delivery system permitting dynamic adjustment of therapy with pinpoint spatial accuracy. We demonstrate that this device can chemically modulate local neuronal activity in small (rodent) and large (nonhuman primate) animal models, while simultaneously allowing the recording of neural activity to enable feedback control.

Sign in / Sign up

Export Citation Format

Share Document