Decisional Authority and Animal Research Subjects

Author(s):  
Andrew Fenton
2015 ◽  
Vol 24 (4) ◽  
pp. 391-406 ◽  
Author(s):  
HOPE R. FERDOWSIAN ◽  
JOHN P. GLUCK

Abstract:In 1966, Henry K. Beecher published an article entitled “Ethics and Clinical Research” in the New England Journal of Medicine, which cited examples of ethically problematic human research. His influential paper drew attention to common moral problems such as inadequate attention to informed consent, risks, and efforts to provide ethical justification. Beecher’s paper provoked significant advancements in human research policies and practices. In this paper, we use an approach modeled after Beecher’s 1966 paper to show that moral problems with animal research are similar to the problems Beecher described for human research. We describe cases that illustrate ethical deficiencies in the conduct of animal research, including inattention to the issue of consent or assent, incomplete surveys of the harms caused by specific protocols, inequitable burdens on research subjects in the absence of benefits to them, and insufficient efforts to provide ethical justification. We provide a set of recommendations to begin to address these deficits.


2019 ◽  
Vol 29 (1) ◽  
pp. 19-37 ◽  
Author(s):  
HOPE FERDOWSIAN ◽  
L. SYD M JOHNSON ◽  
JANE JOHNSON ◽  
ANDREW FENTON ◽  
ADAM SHRIVER ◽  
...  

Abstract:Human and animal research both operate within established standards. In the United States, criticism of the human research environment and recorded abuses of human research subjects served as the impetus for the establishment of the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research, and the resulting Belmont Report. The Belmont Report established key ethical principles to which human research should adhere: respect for autonomy, obligations to beneficence and justice, and special protections for vulnerable individuals and populations. While current guidelines appropriately aim to protect the individual interests of human participants in research, no similar, comprehensive, and principled effort has addressed the use of (nonhuman) animals in research. Although published policies regarding animal research provide relevant regulatory guidance, the lack of a fundamental effort to explore the ethical issues and principles that should guide decisions about the potential use of animals in research has led to unclear and disparate policies. Here, we explore how the ethical principles outlined in the Belmont Report could be applied consistently to animals. We describe how concepts such as respect for autonomy and obligations to beneficence and justice could be applied to animals, as well as how animals are entitled to special protections as a result of their vulnerability.


2006 ◽  
Vol 12 (1) ◽  
pp. 103-110 ◽  
Author(s):  
Czesław Radzikowski

2020 ◽  
Vol 46 (12) ◽  
pp. 840-843
Author(s):  
Jessica du Toit

BackgroundThe practice of giving animal research subjects proper names is frowned on by the academic scientific community. While researchers provide a number of reasons for desisting from giving their animal subjects proper names, the most common are that (1) naming leads to anthropomorphising which, in turn, leads to data and results that are unobjective and invalid; and (2) while naming does not necessarily entail some mistake on the researcher’s part, some feature of the research enterprise renders the practice impossible or ill-advised.ObjectivesMy aim is to assess whether the scientific community’s attitude towards naming animal research subjects is justified. That is, I wish to consider whether the practice of naming animal research subjects is good or bad for the purposes of scientific research.MethodAfter reviewing the extant literature, I constructed a list of the main arguments researchers provide for desisting from naming their animal research subjects. I then analysed these arguments, with a view to determining whether they in fact provide good reasons to avoid naming animal research subjects.ConclusionI argue that none of the aforementioned reasons usually provide good grounds for not naming animal research subjects. Moreover, there are usually powerful reasons in favour of researchers giving their research animals proper names. This is because the practice usually leads to greater empathy and so to improved animal well-being. This, in turn, leads to better animal science. Thus, the scientific community’s attitude towards naming animal research subjects is not justified.


2000 ◽  
Vol 25 (4) ◽  
pp. 328-328
Author(s):  
M.L.Y.M. Oei ◽  
J.M. Segenhout ◽  
F. Dijk ◽  
H.P. Wit ◽  
F.W.J. Albers

2017 ◽  
Author(s):  
Helena Rocklinsberg ◽  
Mickey Gjerris ◽  
Anna Olsson

Crisis ◽  
2012 ◽  
Vol 33 (2) ◽  
pp. 106-112 ◽  
Author(s):  
Christopher M. Bloom ◽  
Shareen Holly ◽  
Adam M. P. Miller

Background: Historically, the field of self-injury has distinguished between the behaviors exhibited among individuals with a developmental disability (self-injurious behaviors; SIB) and those present within a normative population (nonsuicidal self-injury; NSSI),which typically result as a response to perceived stress. More recently, however, conclusions about NSSI have been drawn from lines of animal research aimed at examining the neurobiological mechanisms of SIB. Despite some functional similarity between SIB and NSSI, no empirical investigation has provided precedent for the application of SIB-targeted animal research as justification for pharmacological interventions in populations demonstrating NSSI. Aims: The present study examined this question directly, by simulating an animal model of SIB in rodents injected with pemoline and systematically manipulating stress conditions in order to monitor rates of self-injury. Methods: Sham controls and experimental animals injected with pemoline (200 mg/kg) were assigned to either a low stress (discriminated positive reinforcement) or high stress (discriminated avoidance) group and compared on the dependent measures of self-inflicted injury prevalence and severity. Results: The manipulation of stress conditions did not impact the rate of self-injury demonstrated by the rats. The results do not support a model of stress-induced SIB in rodents. Conclusions: Current findings provide evidence for caution in the development of pharmacotherapies of NSSI in human populations based on CNS stimulant models. Theoretical implications are discussed with respect to antecedent factors such as preinjury arousal level and environmental stress.


1990 ◽  
Vol 45 (11) ◽  
pp. 1270-1271 ◽  
Author(s):  
Kenneth A. Perkins
Keyword(s):  

Sign in / Sign up

Export Citation Format

Share Document