scholarly journals Unique genotypic features of HIV-1 C gp41 membrane proximal external region variants during pregnancy relate to mother-to-child transmission via breastfeeding

2021 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Mother To Child Transmission ◽  
Child Transmission ◽  
External Region ◽  
Membrane Proximal External Region ◽  
Mother To Child ◽  
Hiv 1

scholarly journals Unique Genotypic Features of HIV-1 C Gp41 Membrane Proximal External Region Variants during Pregnancy Relate to Mother-to-child Transmission via Breastfeeding

2020 ◽  
Author(s):  
Li Yin ◽  
Kai-Fen Chang ◽  
Kyle J. Nakamura ◽  
Louise Kuhn ◽  
Grace M. Aldrovandi ◽  
...  
Keyword(s):  
Pediatric Hiv ◽  
Heptad Repeat ◽  
Mother To Child Transmission ◽  
Subtype C ◽  
Child Transmission ◽  
Bioinformatics Pipeline ◽  
External Region ◽  
Membrane Proximal External Region ◽  
Mother To Child ◽  
Hiv 1

ABSTRACTMother-to-child transmission (MTCT) through breastfeeding remains a major source of pediatric HIV-1 infection worldwide. To characterize plasma HIV-1 subtype C populations from infected mothers during pregnancy that related to subsequent breast milk transmission, an exploratory study was designed to apply next generation sequencing and a custom bioinformatics pipeline for HIV-1 gp41 extending from heptad repeat region 2 (HR2) through the membrane proximal external region (MPER) and the membrane spanning domain (MSD). Viral populations during pregnancy from women who transmitted by breastfeeding, compared to those who did not, displayed greater biodiversity, more frequent amino acid polymorphisms, lower hydropathy index and greater positive charge. Viral characteristics were restricted to MPER, failed to extend into flanking HR2 or MSD regions, and were unrelated to predicted neutralization resistance. Findings provide novel parameters to evaluate an association between maternal MPER variants present during gestation and lactogenesis with subsequent transmission outcomes by breastfeeding.IMPORTANCEHIV-1 transmission through breastfeeding accounts for 39% of MTCT and continues as a major route of pediatric infection in developing countries where access to interventions for interrupting transmission is limited. Identifying women who are likely to transmit during breastfeeding would focus therapies during the breastfeeding period to reduce MTCT. Findings from our pilot study identify novel characteristics of gestational viral MPER quasispecies related to transmission outcomes and raise the possibility for predicting MTCT by breastfeeding based on identifying mothers with high-risk viral populations.

Progress in Prevention of Mother-to-Child Transmission of HIV-1 in Zhejiang Province, China, 2007-2013

2014 ◽  
Vol 11 (8) ◽  
pp. 652-657 ◽  
Author(s):  
Xiao-Hui Zhang ◽  
Wei Lu ◽  
Qiong-Yan Wu ◽  
Jing-Yi Jiang ◽  
Dan-Qing Chen ◽  
...  
Keyword(s):  
Zhejiang Province ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Mother To Child ◽  
Hiv 1

Exposure to HIV-1 during delivery and mother-to-child transmission

AIDS ◽  
2000 ◽  
Vol 14 (15) ◽  
pp. 2341-2348 ◽  
Author(s):  
Philippe Gaillard ◽  
Chris Verhofstede ◽  
Fabian Mwanyumba ◽  
Patricia Claeys ◽  
Varsha Chohan ◽  
...  
Keyword(s):  
Mother To Child Transmission ◽  
Child Transmission ◽  
Mother To Child ◽  
Hiv 1

scholarly journals Antenatal HIV-1 RNA load and timing of mother to child transmission; a nested case-control study in a resource poor setting

2010 ◽  
Vol 7 (1) ◽  
Author(s):  
Kerina Duri ◽  
Felicity Z Gumbo ◽  
Knut I Kristiansen ◽  
Nyaradzi E Kurewa ◽  
Munyaradzi P Mapingure ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Resource Poor Setting ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Resource Poor ◽  
Nested Case Control ◽  
Mother To Child ◽  
Hiv 1 ◽  
Control Study

Influence of infant-feeding patterns on early mother-to-child transmission of HIV-1 in Durban, South Africa: a prospective cohort study

The Lancet ◽  
1999 ◽  
Vol 354 (9177) ◽  
pp. 471-476 ◽  
Author(s):  
Anna Coutsoudis ◽  
Kubendran Pillay ◽  
Elizabeth Spooner ◽  
Louise Kuhn ◽  
Hoosen M Coovadia
Keyword(s):  
South Africa ◽  
Cohort Study ◽  
Infant Feeding ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Feeding Patterns ◽  
Mother To Child ◽  
Hiv 1
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