Multiple pulmonary nodules mimicking metastasis in a case of systemic amyloidosis

Amyloidosis is a disorder resulting from the abnormal accumulation of amyloid, a fibrillary protein, in various tissues and organs. Pulmonary amyloidosis can be a part of a systemic process and can mimic other lung diseases which present with multiple pulmonary masses or nodules, such as metastasis. We reported a case of systemic amyloidosis, which is histopathologically confirmed from the nasal lesion, initially presented with multiple lung nodules mimicking pulmonary metastasis but had been stable for years. Pathological study of tissues obtained from three times of percutaneous transthoracic needle biopsy (PTNB) failed to show specific features. The findings on chest radiographs, contrast enhanced thoracic computed tomography (CT) and histology were reviewed and discussed.

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Multiple pulmonary nodules mimicking metastasis in a case of systemic amyloidosis.

The ASEAN Journal of Radiology ◽

10.46475/aseanjr.v21i1.55 ◽

2020 ◽

Vol 21 (1) ◽

pp. 34-43

Author(s):

Warath Chantaksinopas ◽

Papon Prettiwitayakul ◽

Kaewkamol Srichai ◽

Kanet Kanjanapradit

Keyword(s):

Pulmonary Nodules ◽

Systemic Amyloidosis ◽

Transthoracic Needle Biopsy ◽

Amyloid A ◽

Thoracic Computed Tomography ◽

Contrast Enhanced ◽

Abnormal Accumulation ◽

Systemic Process ◽

Pulmonary Amyloidosis ◽

Pulmonary Masses

Amyloidosis is a disorder resulting from the abnormal accumulation of amyloid, a fibrillary protein, in various tissues and organs. Pulmonary amyloidosis can be a part of a systemic process and can mimic other lung diseases which present with multiple pulmonary masses or nodules, such as metastasis.We reported a case of systemic amyloidosis, which is histopathologically confirmed from the nasal lesion, initially presented with multiple lung nodules mimicking pulmonary metastasis but had been stable for years. Pathological study of tissues obtained from three times of percutaneous transthoracic needle biopsy (PTNB) failed to show specific features. The findings on chest radiographs, contrast enhanced thoracic computed tomography (CT) and histology were reviewed and discussed.

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Primary pulmonary lymphoma presenting as nodules and masses: a case report and literature review

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2021.1259 ◽

2021 ◽

Vol 91 (1) ◽

Author(s):

Xiaofang Gao ◽

Peng Yan

Keyword(s):

Histopathological Examination ◽

Pulmonary Nodules ◽

Transthoracic Needle Biopsy ◽

Ct Guided ◽

Primary Pulmonary Lymphoma ◽

Contrast Enhanced ◽

Pulmonary Lymphoma ◽

Old Men ◽

Percutaneous Transthoracic Needle Biopsy ◽

Multiple Nodules

Primary pulmonary lymphoma (PPL) is a rare neoplasm. We report a case of 45-year-old men who was admitted to hospital for multiple nodules and masses in both lungs. The contrast enhanced chest CT scans revealed multiple nodules and masses of varying sizes in right upper and middle lobes and both lower lobes. CT-guided percutaneous transthoracic needle biopsy was performed. The diagnosis of PPL was confirmed by histopathological examination and Immunohistochemical staining. PPL should be included in the differential diagnoses in symptomless patients with multiple pulmonary nodules and masses.

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Nodular Pulmonary Amyloidosis Mimicking Metastatic Pulmonary Nodules: A case report and review of the literature

Sultan Qaboos University Medical Journal [SQUMJ] ◽

10.18295/squmj.2018.18.03.023 ◽

2018 ◽

Vol 18 (3) ◽

pp. 393

Author(s):

Rashid S. Al-Umairi ◽

Fatma Al-Lawati ◽

Fadhila M. Al-Busaidi

Keyword(s):

Computed Tomography ◽

Case Report ◽

Histopathological Examination ◽

Pulmonary Nodules ◽

Royal Hospital ◽

Amyloid A ◽

History Of ◽

Chest X Ray ◽

Bilateral Lower Limb ◽

Pulmonary Amyloidosis

Amyloidosis is a disorder characterised by the extracellular deposition of amyloid, a fibrillary protein, in various organs such as the lungs. Pulmonary nodular amyloidosis can mimic other lung conditions that present with pulmonary nodules, such as metastasis, sarcoidosis and hyalinising granuloma. We report a 60-year-old man who presented to the Royal Hospital, Muscat, Oman, in 2017 with a history of shortness of breath upon exertion, orthopnoea and bilateral lower limb swelling. A chest X-ray showed bilateral nodular opacities. Enhanced chest computed tomography revealed bilateral pulmonary nodules with a predominantly perilymphatic and subpleural distribution, giving the impression of a neoplastic nodule. A histopathological examination of biopsied lung tissue confirmed a diagnosis of nodular pulmonary amyloidosis.Keywords: Multiple Pulmonary Nodules; Amyloidosis; Computed Tomography; Case Report; Oman.

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Optimal breathing protocol for dynamic contrast-enhanced MRI of solitary pulmonary nodules at 3T

European Journal of Radiology ◽

10.1016/j.ejrad.2007.08.014 ◽

2007 ◽

Vol 64 (3) ◽

pp. 397-400 ◽

Cited By ~ 4

Author(s):

Aya Kino ◽

Masaya Takahashi ◽

Simon K. Ashiku ◽

Malcolm M. Decamp ◽

Robert E. Lenkinski ◽

...

Keyword(s):

Pulmonary Nodules ◽

Solitary Pulmonary Nodules ◽

Dynamic Contrast Enhanced Mri ◽

Dynamic Contrast Enhanced ◽

Enhanced Mri ◽

Contrast Enhanced ◽

Contrast Enhanced Mri

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Methods to study the structure of misfolded protein states in systemic amyloidosis

Biochemical Society Transactions ◽

10.1042/bst20201022 ◽

2021 ◽

Vol 49 (2) ◽

pp. 977-985

Author(s):

Marcus Fändrich ◽

Matthias Schmidt

Keyword(s):

Protein Misfolding ◽

Amyloid Fibrils ◽

Ex Vivo ◽

Systemic Amyloidosis ◽

Structural Basis ◽

Amyloid A ◽

Serum Amyloid A Protein ◽

Proteolytic Stability

Systemic amyloidosis is defined as a protein misfolding disease in which the amyloid is not necessarily deposited within the same organ that produces the fibril precursor protein. There are different types of systemic amyloidosis, depending on the protein constructing the fibrils. This review will focus on recent advances made in the understanding of the structural basis of three major forms of systemic amyloidosis: systemic AA, AL and ATTR amyloidosis. The three diseases arise from the misfolding of serum amyloid A protein, immunoglobulin light chains or transthyretin. The presented advances in understanding were enabled by recent progress in the methodology available to study amyloid structures and protein misfolding, in particular concerning cryo-electron microscopy (cryo-EM) and nuclear magnetic resonance (NMR) spectroscopy. An important observation made with these techniques is that the structures of previously described in vitro formed amyloid fibrils did not correlate with the structures of amyloid fibrils extracted from diseased tissue, and that in vitro fibrils were typically more protease sensitive. It is thus possible that ex vivo fibrils were selected in vivo by their proteolytic stability.

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