CS-7 A case of Lymphomatoid granulomatosis with skin, lung, and intracranial lesions due to multicentric development

Introduction: LYG is very rare tumor and composed of large EB-positive B cells and reactive T cells. In this study, we experienced a case of LYG with multiple intracranial, cutaneous, and pulmonary masses. We report the pathogenesis and pathophysiology of LYG, including a discussion of the literature. case: A 69-year-old female presented with a growing lump in her lower back that had been present for several years. Six months later, she was found to have multiple masses in her lungs and intracranial region and underwent surgical removal for diagnostic purposes. Intraoperative findings: The tumor was substantial, reddish to grayish-white in color, and the margins of the tumor were whitish and hard, with some areas that could not be detached. Pathological findings: There were no atypical lymphocytes, and a small number of EBER-positive cells were observed. IgVH PCR: IgVH PCR was performed on the skin lesions and intracranial lesions, and bands of different sizes were detected, suggesting that the IgVH clone was present in the polyclonal region. Finally, we diagnosed LYG grade 1. discussion: EB-associated lymphoproliferative disease can lead to polyclonal reactive growth or monoclonal neoplastic growth depending on the balance between morphology and host immunity. The results of IgVH PCR suggest that the skin lesions did not cause multiple metastases, but rather that the enlargement of the skin lesions triggered intracranial and pulmonary lesions in an allo-centric manner. The results of IgVH PCR suggested that the skin lesions did not cause multiple metastases, but rather that the skin lesions grew to cause intracranial and pulmonary involvement in an other-centric manner.

Radiographic manifestations of inoperable primary bronchogenic carcinoma

Bronchogenic carcinoma should be a topic of paramount importance to all who interpret chest radiographs because of its increasing incidence. For several decades the disease has been underestimated in the developing world. A prospective study was carried out on 52 patients (43 males, 9 females) with primary bronchogenic carcinoma at Oncology Teaching Hospital/Medical City-Baghdad from October 2016 to March 2017. All patients had standard plain chest radiographs (postero-anterior, and lateral views). Any abnormality detected was further studied with conventional tomography. The diagnosis was confirmed by histopathology examinations for all patients who were clinically evaluated by other methods of investigations. Most patients had more than one radiological feature which were mainly pulmonary masses, either hilar or peripheral or both at the same time. Other less common features were; mediastinal adenopathy (27%), atelactasis (25%) and pleural effusion (21%). Radiological signs that determine inoperability were evaluated together with other factors that were used as basic principles in the assessment of inoperability. From the total of fifty-two patients; 45 (86.5%) were inoperable radiologically and clinically, and also 4 patients (57%) out of the 7 who underwent thoracotomy were inoperable due to invasion and adhesion to the vessels and other vital structures. The chest radiograph is still important, cheap and available diagnostic procedure in lung cancer, and to decide further management.

Subcutaneous fibrosarcomas with pulmonary metastases in a white tiger (Panthera tigris) and a lion (Panthera leo)

Two cases of recurrent subcutaneous fibrosarcomas in a white tiger and a lion were observed and the animals were euthanised humanely due to clinical deterioration. In both animals, postmortem examination revealed multinodular, white to fawn, firm to greasy, subcutaneous masses at the left side of the thorax infiltrating into the adjacent musculature. Furthermore, the tiger showed a single mass and the lion multiple masses in the lung. Histopathologically, the subcutaneous and pulmonary masses consisted of spindle-shaped neoplastic cells with necrotic areas, and infiltration with multinucleated giant cells and lymphocytes. Immunohistochemically, tumour cells labelled positive for vimentin and negative for desmin, factor VIII-related antigen, smooth muscle actin S100, CD31 and nerve growth factor receptor p75. Thus, the pulmonary tumours were diagnosed as metastases of subcutaneous fibrosarcomas. Like domestic cats, also large, non-domestic felids could be predisposed for metastasising fibrosarcoma, which may be associated with injections or trauma.

Multiple pulmonary nodules mimicking metastasis in a case of systemic amyloidosis

Amyloidosis is a disorder resulting from the abnormal accumulation of amyloid, a fibrillary protein, in various tissues and organs. Pulmonary amyloidosis can be a part of a systemic process and can mimic other lung diseases which present with multiple pulmonary masses or nodules, such as metastasis. We reported a case of systemic amyloidosis, which is histopathologically confirmed from the nasal lesion, initially presented with multiple lung nodules mimicking pulmonary metastasis but had been stable for years. Pathological study of tissues obtained from three times of percutaneous transthoracic needle biopsy (PTNB) failed to show specific features. The findings on chest radiographs, contrast enhanced thoracic computed tomography (CT) and histology were reviewed and discussed.

Multiple pulmonary nodules mimicking metastasis in a case of systemic amyloidosis.

Amyloidosis is a disorder resulting from the abnormal accumulation of amyloid, a fibrillary protein, in various tissues and organs. Pulmonary amyloidosis can be a part of a systemic process and can mimic other lung diseases which present with multiple pulmonary masses or nodules, such as metastasis.We reported a case of systemic amyloidosis, which is histopathologically confirmed from the nasal lesion, initially presented with multiple lung nodules mimicking pulmonary metastasis but had been stable for years. Pathological study of tissues obtained from three times of percutaneous transthoracic needle biopsy (PTNB) failed to show specific features. The findings on chest radiographs, contrast enhanced thoracic computed tomography (CT) and histology were reviewed and discussed.