scholarly journals Vulvar Lichen Sclerosus et Atrophicus in girls

2021 ◽  
Vol 24 (5) ◽  
pp. 356-360
Author(s):  
Leila V. Adamyan ◽  
Sergey M. Sharkov ◽  
Elena V. Sibirskaya ◽  
Laura G. Pivazyan ◽  
Julietta S. Avetisyan
Keyword(s):  
Randomized Clinical Trials ◽  
Clinical Symptoms ◽  
Case Series ◽  
Lichen Sclerosus ◽  
Genetic Mutations ◽  
Lichen Sclerosus Et Atrophicus ◽  
Inflammatory Dermatosis ◽  
Anogenital Region ◽  
Literature Reviews ◽  
Vulvar Lichen Sclerosus

The review is devoted to diagnosing and treating lichen sclerosus (LS), a chronic inflammatory dermatosis with a predisposition to lesions of the anogenital region in girls. An essential role in the aetiology of this form of pathology is attributed to genetic mutations, injuries, infections and autoimmune diseases, and hormonal and local factors. The peak incidence is observed in 4-6 year girls, accounting for 7-15% of all cases of vulvar LS. The main goal of pharmacotherapy for vulvar LS is to relieve clinical symptoms and prevent scarring and adhesions. The authors analyzed international and domestic publications from 2017 to 2021. PubMed and Google Academy databases were used for the search, keywords: lichen sclerosus, girls. The retrospective and prospective cohort, randomized clinical trials, case series and literature reviews, and clinical guidelines were considered. Our review presents modern data on the diagnosis and treatment of SL in girls, which will be useful for both pediatric gynecologists and doctors of related specialties. The first symptoms of LS are usually nonspecific and are misdiagnosed by non-profile specialists. Some symptoms of LS may disappear spontaneously after menarche, and the course of the disease may be latent. This is why it is generally accepted that the epidemiology of LS is underestimated. Despite this, it can be assumed that the etiology and pathogenesis of LS is probably multifactorial. This review describes several leading etiological factors regarding the potential etiopathogenesis of vulvar LS in girls.

scholarly journals Immunohistochemical Evidence of Skin Immune System Involvement in Vulvar Lichen sclerosus et atrophicus

Dermatology ◽  
1991 ◽  
Vol 182 (1) ◽  
pp. 18-22 ◽  
Author(s):  
P. Carli ◽  
A. Cattaneo ◽  
N. Pimpinelli ◽  
A. Cozza ◽  
G. Bracco ◽  
...  
Keyword(s):  
Immune System ◽  
Lichen Sclerosus ◽  
Lichen Sclerosus Et Atrophicus ◽  
System Involvement ◽  
Skin Immune System ◽  
Immunohistochemical Evidence ◽  
Vulvar Lichen Sclerosus

scholarly journals Nonablative radiofrequency in the treatment of refractory vulvar lichen sclerosus: A case series

2021 ◽  
Author(s):  
Rodrigo Rossi Balbinotti ◽  
Fernanda Santos Grossi ◽  
Amanda Vilaverde Perez ◽  
Mariana Sbaraini ◽  
Luciana Borges Chagas ◽  
...  
Keyword(s):  
Case Series ◽  
Lichen Sclerosus ◽  
Vulvar Lichen Sclerosus

Lichen sclerosis et atrophicus masquerading as tonsillar squamous cell carcinoma

2008 ◽  
Vol 123 (2) ◽  
Author(s):  
O Ajayi ◽  
J C Stephens ◽  
S Karim ◽  
N Daly
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
World Literature ◽  
Lichen Sclerosus ◽  
Lichen Sclerosus Et Atrophicus ◽  
Diagnostic Challenge ◽  
Asian Origin ◽  
Inflammatory Dermatosis ◽  
Epidermal Atrophy

AbstractObjective:We report a case of a 70-year-old man of Asian origin with lichen sclerosus et atrophicus affecting the tonsil, which presented as a painful, enlarging, exophytic lesion mimicking squamous cell carcinoma.Method:We present a case report and a review of the world literature regarding lichen sclerosus et atrophicus.Results:Lichen sclerosus is a chronic, benign, inflammatory dermatosis of the skin and mucous membranes which mostly affects the female genitalia, presenting as white plaques with epidermal atrophy. The cause is unknown, although a number of aetiologies have been proposed. The prevalence is unknown. Women have been reported to be affected six to 10 times more than men, and the condition has no known racial preference.Conclusion:Our patient illustrates a rare case of the condition lichen sclerosus et atrophicus; to our knowledge, this case represents the first report of tonsillar involvement of the condition. The case presented a diagnostic challenge.

scholarly journals Effects of Intravenous Ketamine Infusions in a Neuropathic Pain Patient with Lichen Sclerosus et Atrophicus

2016 ◽  
Vol 8 (2) ◽  
pp. 166-172 ◽  
Author(s):  
Ashraf F. Hanna ◽  
Josh S. Armstrong ◽  
Adam J. Smith
Keyword(s):  
Therapeutic Option ◽  
Lichen Sclerosus ◽  
Pain Syndrome ◽  
Opioid Therapy ◽  
Pain Patient ◽  
Lichen Sclerosus Et Atrophicus ◽  
Clinical Observations ◽  
Anogenital Region ◽  
Patient Reported ◽  
Intravenous Ketamine

A patient reported to the Florida Spine Institute (Clearwater, Fla., USA) with severe lichen sclerosus of the anogenital region and legs. The patient’s pain presentation was neuropathic with hypersensitivity, allodynia, swelling, and weakness. The patient had failed multiple pain management modalities including opioid therapy, anticonvulsants, and antidepressants. The patient completed a standard intravenous ketamine infusion regimen developed at the Florida Spine Institute and reported complete abolishment of her pain syndrome. For the first time, we report that ketamine infusions also dramatically improved a patient’s lichen sclerosus. That ketamine is known to have immunomodulatory properties, and given the clinical observations described in this case report, suggests that ketamine should be explored as a possible new therapeutic option for managing lichen sclerosus, especially in cases that are refractory to conventional therapies.

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