Cannabinoid Receptor 1: Allosteric Modulation and its Therapeutic Potential

2020 ◽  
Vol 9 (8) ◽  
pp. 102-110
Author(s):  
Debra A. Kendall ◽  
Jonathan Choiniere
Keyword(s):  
Cannabinoid Receptor ◽  
Therapeutic Potential ◽  
Allosteric Modulation ◽  
Cannabinoid Receptor 1

Multiple sclerosis following treatment with a cannabinoid receptor-1 antagonist

2004 ◽  
Vol 10 (3) ◽  
pp. 330-332 ◽  
Author(s):  
B W van Oosten ◽  
J Killestein ◽  
E MH Mathus-Vliegen ◽  
C H Polman
Keyword(s):  
Multiple Sclerosis ◽  
Animal Models ◽  
Receptor Antagonist ◽  
Human Disease ◽  
Cannabinoid Receptor ◽  
Therapeutic Potential ◽  
Laboratory Research ◽  
Cannabinoid Receptor 1 ◽  
Disease Pathogenesis

Laboratory research including animal models of human disease suggests that cannabinoids might have therapeutic potential in multiple sclerosis (MS). We have recently seen a 46-year-old woman who developed MS after starting treatment with a cannabino id recepto r antagonist for obesity. The occurrence of MS several months after starting a cannabinoid receptor antagonist suggests that the cannabino id system might indeed be relevant to disease pathogenesis in MS.

Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermis

2020 ◽  
Vol 29 (7) ◽  
pp. 616-622 ◽  
Author(s):  
Attila Oláh ◽  
Majid Alam ◽  
Jérémy Chéret ◽  
Nikolett Gréta Kis ◽  
Zoltán Hegyi ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cannabinoid Receptor ◽  
Human Epidermis ◽  
Cannabinoid Receptor 1 ◽  
Mitochondrial Energy Metabolism
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