Serum HDL-c and LDL-c levels as the predictors of COVID-19 severity

Background: Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) and comes with various degrees of severity from mild to critical conditions. This study aims to evaluate and clarify the roles of serum HDL-c and LDL-c levels in predicting the COVID-19 severity.

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Recent advances in mechanical ventilation in patients with acute respiratory distress syndrome

European Respiratory Review ◽

10.1183/09059180.00012414 ◽

2015 ◽

Vol 24 (135) ◽

pp. 132-140 ◽

Cited By ~ 27

Author(s):

Nuttapol Rittayamai ◽

Laurent Brochard

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome ◽

Ventilator Induced Lung Injury ◽

Monitoring Tools ◽

Protective Strategy ◽

Volume Measurements ◽

Severity Of The Disease ◽

Degrees Of Severity

Acute respiratory distress syndrome (ARDS) is characterised by different degrees of severity and different stages. Understanding these differences can help to better adapt the ventilatory settings to protect the lung from ventilator-induced lung injury by reducing hyperinflation or keeping the lung open when it is possible. The same therapies may be useful and beneficial in certain forms of ARDS, and risky or harmful at other stages: this includes high positive end-expiratory pressure, allowance of spontaneous breathing activity or use of noninvasive ventilation. The severity of the disease is the primary indicator to individualise treatment. Monitoring tools such as oesophageal pressure or lung volume measurements may also help to set the ventilator. At an earlier stage, an adequate lung protective strategy may also help to prevent the development of ARDS.

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Critical Illness Polyneuropathy and Myopathy in Patients With Acute Respiratory Distress Syndrome

Yearbook of Pulmonary Disease ◽

10.1016/s8756-3452(08)70229-9 ◽

2006 ◽

Vol 2006 ◽

pp. 283-284

Author(s):

J.A. Barker

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Critical Illness ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome ◽

Critical Illness Polyneuropathy

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Acute Respiratory Distress Syndrome

10.1017/cbo9780511575112 ◽

1999 ◽

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome

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COVID-19 – eine vaskuläre Systemerkrankung

Der Klinikarzt ◽

10.1055/a-1261-8676 ◽

2020 ◽

Vol 49 (10) ◽

pp. 418-421

Author(s):

Christopher Werlein ◽

Peter Braubach ◽

Vincent Schmidt ◽

Nicolas J. Dickgreber ◽

Bruno Märkl ◽

...

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome

ZUSAMMENFASSUNGDie aktuelle COVID-19-Pandemie verzeichnet mittlerweile über 18 Millionen Erkrankte und 680 000 Todesfälle weltweit. Für die hohe Variabilität sowohl der Schweregrade des klinischen Verlaufs als auch der Organmanifestationen fanden sich zunächst keine pathophysiologisch zufriedenstellenden Erklärungen. Bei schweren Krankheitsverläufen steht in der Regel eine pulmonale Symptomatik im Vordergrund, meist unter dem Bild eines „acute respiratory distress syndrome“ (ARDS). Darüber hinaus zeigen sich jedoch in unterschiedlicher Häufigkeit Organmanifestationen in Haut, Herz, Nieren, Gehirn und anderen viszeralen Organen, die v. a. durch eine Perfusionsstörung durch direkte oder indirekte Gefäßwandschädigung zu erklären sind. Daher wird COVID-19 als vaskuläre Multisystemerkrankung aufgefasst. Vor dem Hintergrund der multiplen Organmanifestationen sind klinisch-pathologische Obduktionen eine wichtige Grundlage der Entschlüsselung der Pathomechanismen von COVID-19 und auch ein Instrument zur Generierung und Hinterfragung innovativer Therapieansätze.

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