scholarly journals Disease and Adverse Drug Reaction Prediction using Machine Learning

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Reshma Mathai ◽  
Ardra K John ◽  
Anima M M ◽  
Athulya James ◽  
Lakshmi K S
Keyword(s):  
Machine Learning ◽  
Risk Prediction ◽  
Adverse Drug Reactions ◽  
Disease Risk ◽  
Machine Learning Techniques ◽  
Drug Reactions ◽  
Prediction Risk ◽  
Android App ◽  
Web App ◽  
Project Location

The aim of the project is to use machine learning techniques for disease prediction, risk prediction and prediction of adverse drug reactions. The project is divided into two modules, an android app and a web app. The android app is to predict possible diseases based on the symptoms the person is showing. Along with that the reviews of common drugs from online healthcare forums such as medications.com are extracted and tf-idf is used to find out the possible adverse drug reactions the drugs may have. The web app does disease risk prediction based on phenotypic details and lab reports. As an addition to the project, location based medical help and health tips are also implemented.

scholarly journals Deep Learning Prediction of Adverse Drug Reactions in Drug Discovery Using Open TG–GATEs and FAERS Databases

2021 ◽  
Vol 1 ◽  
Author(s):  
Attayeb Mohsen ◽  
Lokesh P. Tripathi ◽  
Kenji Mizuguchi
Keyword(s):  
Machine Learning ◽  
Drug Discovery ◽  
Adverse Drug Reactions ◽  
Predictive Models ◽  
Prediction Models ◽  
Expression Profiles ◽  
Fine Tuning ◽  
Machine Learning Techniques ◽  
Drug Reactions ◽  
Wide Range

Machine learning techniques are being increasingly used in the analysis of clinical and omics data. This increase is primarily due to the advancements in Artificial intelligence (AI) and the build-up of health-related big data. In this paper we have aimed at estimating the likelihood of adverse drug reactions or events (ADRs) in the course of drug discovery using various machine learning methods. We have also described a novel machine learning-based framework for predicting the likelihood of ADRs. Our framework combines two distinct datasets, drug-induced gene expression profiles from Open TG–GATEs (Toxicogenomics Project–Genomics Assisted Toxicity Evaluation Systems) and ADR occurrence information from FAERS (FDA [Food and Drug Administration] Adverse Events Reporting System) database, and can be applied to many different ADRs. It incorporates data filtering and cleaning as well as feature selection and hyperparameters fine tuning. Using this framework with Deep Neural Networks (DNN), we built a total of 14 predictive models with a mean validation accuracy of 89.4%, indicating that our approach successfully and consistently predicted ADRs for a wide range of drugs. As case studies, we have investigated the performances of our prediction models in the context of Duodenal ulcer and Hepatitis fulminant, highlighting mechanistic insights into those ADRs. We have generated predictive models to help to assess the likelihood of ADRs in testing novel pharmaceutical compounds. We believe that our findings offer a promising approach for ADR prediction and will be useful for researchers in drug discovery.

A Pharmaco-Cybernetics Approach to Patient Safety

2016 ◽  
pp. 1445-1464
Author(s):  
Kevin Yi-Lwern Yap
Keyword(s):  
Machine Learning ◽  
Patient Safety ◽  
Cancer Patients ◽  
Adverse Drug Reactions ◽  
Principal Component ◽  
Machine Learning Techniques ◽  
Drug Reactions ◽  
Internet Applications ◽  
Case Examples ◽  
Learning Techniques

Pharmaco-cybernetics is an upcoming interdisciplinary field that supports our use of medicines and drugs through the combined use of computational technologies and techniques with human-computer-environment interactions to reduce or prevent drug-related problems. The advent of pharmaco-cybernetics has led to the development of various software, tools, and Internet applications that can be used by healthcare practitioners to deliver optimum pharmaceutical care and health-related outcomes. Patients are becoming more informed through health information on the Internet, which empowers them to better participate in the management of their own conditions. Focusing on patients with cancer, this chapter describes the use of a pharmaco-cybernetics approach to identify clinically relevant predictors of two debilitating adverse drug reactions, which are a cause of patient safety – chemotherapy-induced nausea and vomiting and febrile neutropenia. The early identification of such clinical predictors enables clinicians to prevent or reduce the occurrence of adverse drug reactions in cancer patients undergoing chemotherapy through appropriate management strategies. The computational methods used in this approach involve two unsupervised machine-learning techniques – principal component and multiple correspondence analyses. Using two case examples, this chapter shows the potential of machine-learning techniques for identifying patients who are at greater risks of these adverse drug reactions, thus enhancing patient safety. This chapter also aims to increase the awareness among healthcare professionals and clinician-scientists about the usefulness of such techniques in clinical patient populations, so that these can be considered as part of clinical care pathways to enhance patient safety and effectively manage cancer patients on chemotherapy.

A Pharmaco-Cybernetics Approach to Patient Safety

2014 ◽  
pp. 179-197
Author(s):  
Kevin Yi-Lwern Yap
Keyword(s):  
Machine Learning ◽  
Patient Safety ◽  
Cancer Patients ◽  
Adverse Drug Reactions ◽  
Principal Component ◽  
Machine Learning Techniques ◽  
Drug Reactions ◽  
Internet Applications ◽  
Case Examples ◽  
Learning Techniques

Pharmaco-cybernetics is an upcoming interdisciplinary field that supports our use of medicines and drugs through the combined use of computational technologies and techniques with human-computer-environment interactions to reduce or prevent drug-related problems. The advent of pharmaco-cybernetics has led to the development of various software, tools, and Internet applications that can be used by healthcare practitioners to deliver optimum pharmaceutical care and health-related outcomes. Patients are becoming more informed through health information on the Internet, which empowers them to better participate in the management of their own conditions. Focusing on patients with cancer, this chapter describes the use of a pharmaco-cybernetics approach to identify clinically relevant predictors of two debilitating adverse drug reactions, which are a cause of patient safety – chemotherapy-induced nausea and vomiting and febrile neutropenia. The early identification of such clinical predictors enables clinicians to prevent or reduce the occurrence of adverse drug reactions in cancer patients undergoing chemotherapy through appropriate management strategies. The computational methods used in this approach involve two unsupervised machine-learning techniques – principal component and multiple correspondence analyses. Using two case examples, this chapter shows the potential of machine-learning techniques for identifying patients who are at greater risks of these adverse drug reactions, thus enhancing patient safety. This chapter also aims to increase the awareness among healthcare professionals and clinician-scientists about the usefulness of such techniques in clinical patient populations, so that these can be considered as part of clinical care pathways to enhance patient safety and effectively manage cancer patients on chemotherapy.

A Pharmaco-Cybernetics Approach to Patient Safety

2017 ◽  
pp. 1291-1310
Author(s):  
Kevin Yi-Lwern Yap
Keyword(s):  
Machine Learning ◽  
Patient Safety ◽  
Cancer Patients ◽  
Adverse Drug Reactions ◽  
Principal Component ◽  
Machine Learning Techniques ◽  
Drug Reactions ◽  
Internet Applications ◽  
Case Examples ◽  
Learning Techniques

Pharmaco-cybernetics is an upcoming interdisciplinary field that supports our use of medicines and drugs through the combined use of computational technologies and techniques with human-computer-environment interactions to reduce or prevent drug-related problems. The advent of pharmaco-cybernetics has led to the development of various software, tools, and Internet applications that can be used by healthcare practitioners to deliver optimum pharmaceutical care and health-related outcomes. Patients are becoming more informed through health information on the Internet, which empowers them to better participate in the management of their own conditions. Focusing on patients with cancer, this chapter describes the use of a pharmaco-cybernetics approach to identify clinically relevant predictors of two debilitating adverse drug reactions, which are a cause of patient safety – chemotherapy-induced nausea and vomiting and febrile neutropenia. The early identification of such clinical predictors enables clinicians to prevent or reduce the occurrence of adverse drug reactions in cancer patients undergoing chemotherapy through appropriate management strategies. The computational methods used in this approach involve two unsupervised machine-learning techniques – principal component and multiple correspondence analyses. Using two case examples, this chapter shows the potential of machine-learning techniques for identifying patients who are at greater risks of these adverse drug reactions, thus enhancing patient safety. This chapter also aims to increase the awareness among healthcare professionals and clinician-scientists about the usefulness of such techniques in clinical patient populations, so that these can be considered as part of clinical care pathways to enhance patient safety and effectively manage cancer patients on chemotherapy.

Long-term Cholesterol Risk Prediction using Machine Learning Techniques in ELSA Database

2021 ◽  
Author(s):  
Nikos Fazakis ◽  
Elias Dritsas ◽  
Otilia Kocsis ◽  
Nikos Fakotakis ◽  
Konstantinos Moustakas
Keyword(s):  
Machine Learning ◽  
Risk Prediction ◽  
Machine Learning Techniques ◽  
Learning Techniques
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