Laparoscopic gastrectomy in remnant gastric cancer

Objective: Remnant Gastric Cancer (RGC) describes cancers occurring in the remaining stomach and/or anastomosis in the follow-up after gastric cancer or benign gastric surgery. RGC is diagnosed in esophago-gastroscopy follow-ups of patients who underwent this surgery in the past. Again, the increase in the success of gastric cancer surgery and following medical treatments has increased the incidence of RGC in long-term follow-up after gastric cancer surgery. Laparoscopic surgery has been also reported in few cases. In the present study, the purpose was to present the results of the first five patients that underwent laparoscopic total gastrectomy due to RGC in our clinic. Material and Methods: The patients who underwent laparoscopic gastric cancer surgery between November 2014 and December 2018 were evaluated retrospectively. Results: Mean age of the patients was 62.4 years (ranging between 49 and 74 years). Two of these patients had a surgical history due to gastric cancer and 3 due to peptic ulcer. Surgery was completed laparoscopically in all patients. In the early period, one patient had to undergo re-surgery due to stenosis in Jejuno-Jejunostomy, and the patient died. One patient underwent laparotomy due to colonic stenosis in the second month after the surgery. Recurrence was detected on the 140th and 180th days of follow-up in the other two patients. Conclusion: Laparoscopic surgery is a technically applicable method in RGC; however, it is also a risk factor for past surgical postoperative complications. Early recurrence in this group of patients requires a comparison of open and laparoscopic surgery.

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Case report about a successful full robotic radical gastric cancer surgery with intracorporeal robot-sewn anastomosis in a patient with situs inversus totalis and a two-and-a-half-year follow-up study

World Journal of Surgical Oncology ◽

10.1186/s12957-018-1311-z ◽

2018 ◽

Vol 16 (1) ◽

Cited By ~ 3

Author(s):

Hai-Bin Dai ◽

Zhi-Chun Wang ◽

Xiao-Bo Feng ◽

Gang Wang ◽

Wei-Yan Li ◽

...

Keyword(s):

Gastric Cancer ◽

Case Report ◽

Situs Inversus ◽

Situs Inversus Totalis ◽

Cancer Surgery ◽

Gastric Cancer Surgery ◽

Follow Up Study

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Follow-Up Surveillance for Recurrence After Curative Gastric Cancer Surgery Lacks Survival Benefit

Annals of Surgical Oncology ◽

10.1245/aso.2003.12.009 ◽

2003 ◽

Vol 10 (8) ◽

pp. 898-902 ◽

Cited By ~ 62

Author(s):

Yasuhiro Kodera ◽

Seiji Ito ◽

Yoshitaka Yamamura ◽

Yoshinari Mochizuki ◽

Michitaka Fujiwara ◽

...

Keyword(s):

Gastric Cancer ◽

Survival Benefit ◽

Cancer Surgery ◽

Gastric Cancer Surgery

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The Contribution of the Hunger Hormone Leptin in the Aetiology of Postoperative Anorexia After Laparoscopic and Open Gastrectomy in Gastric Cancer Patients

10.20944/preprints202109.0263.v1 ◽

2021 ◽

Author(s):

Tomaz Jagric

Keyword(s):

Gastric Cancer ◽

Laparoscopic Surgery ◽

Open Surgery ◽

Relative Concentration ◽

Serum Levels ◽

Cancer Surgery ◽

Tumour Grade ◽

Perioperative Therapy ◽

Serum Leptin ◽

Gastric Cancer Surgery

Background: Laparoscopic surgery produces lesser postoperative inflammation with a smaller cytokine and leptin response, and might thus reduce postoperative anorexia compared to open surgery. The aim of the present study was to determine the role of serum leptin in postoperative anorexia after laparoscopic gastric cancer surgery. Methods: Fifty-four consecutive patients with adenocarcinoma of the stomach were operated on either with open or laparoscopic surgery. Correlations were determined between the serum levels of leptin, clinico-pathological characteristics, serum haemoglobin and albumin. Results: Serum leptin levels on day seven were correlated significantly to gender (p=0.004), BMI (p=0.002) and tumour grade (p=0.033). In the patients with CRP < 100 mg/l the leptin levels on day seven were significantly lower after the laparoscopic operation (p=0.042) and in patients with lower BMI (p=0.001). The linear regression model determined a significant correlation between the relative concentration of leptin on day seven and laparoscopic surgery (Beta -0.688; p < 0.0001), gender, BMI, location of the tumour, T stage, N stage, perioperative therapy, tumour grade, perineural invasion, Lauren histological type and ulceration. In patients with CRP levels below 100 mg/ml the serum level of albumin on day seven after surgery was significantly higher in patients after laparoscopic surgery. Conclusion: Laparoscopic surgery produced significantly lower relative leptin concentrations on day seven, and higher serum albumin levels in the subgroup with CRP levels below 100 mg/l at discharge. These results suggested that laparoscopic gastric cancer surgery might reduce postoperative leptin response, leading to a better nutritional status at discharge compared to open surgery.

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The Contribution of the Hunger Hormone Leptin in the Aetiology of Postoperative Anorexia after Laparoscopic and Open Gastrectomy in Gastric Cancer Patients

Biomolecules ◽

10.3390/biom11111601 ◽

2021 ◽

Vol 11 (11) ◽

pp. 1601

Author(s):

Tomaz Jagric

Keyword(s):

Gastric Cancer ◽

Laparoscopic Surgery ◽

Open Surgery ◽

Relative Concentration ◽

Serum Levels ◽

Cancer Surgery ◽

Tumour Grade ◽

Perioperative Therapy ◽

Serum Leptin ◽

Gastric Cancer Surgery

Background: Laparoscopic surgery produces lesser postoperative inflammation with a smaller cytokine and leptin response, and might thus reduce postoperative anorexia compared with open surgery. The aim of the present study was to determine the role of serum leptin in postoperative anorexia after laparoscopic gastric cancer surgery. Methods: Fifty-four consecutive patients with adenocarcinoma of the stomach were operated on either with open or laparoscopic surgery. Correlations were determined between the serum levels of leptin, clinico-pathological characteristics, serum haemoglobin, and albumin. Results: Serum leptin levels on day seven were correlated significantly to gender (p = 0.004), body mass index (BMI) (p = 0.002), and tumour grade (p = 0.033). In the patients with C-reactive protein (CRP) < 100 mg/L (n = 46) the leptin levels on day seven were significantly lower after the laparoscopic operation (p = 0.042) and in patients with lower BMI (p = 0.001). The linear regression model determined a significant correlation between the relative concentration of leptin on day seven and laparoscopic surgery (Beta−0.688; p < 0.0001), gender, BMI, location of the tumour, T stage, N stage, perioperative therapy, tumour grade, perineural invasion, Lauren histological type, and ulceration. In patients with CRP levels below 100 mg/mL, the serum level of albumin on day seven after surgery was significantly higher in patients after laparoscopic surgery. Conclusion: Laparoscopic surgery produced significantly lower relative leptin concentrations on day seven, and higher serum albumin levels in the subgroup with CRP levels below 100 mg/L at discharge. These results suggested that laparoscopic gastric cancer surgery might reduce postoperative leptin response, leading to a better nutritional status at discharge compared with open surgery.

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Clockwise, Modularized Lymphadenectomy in Laparoscopic Gastric Cancer Surgery: a New Laparoscopic Surgery Model

Journal of Gastrointestinal Surgery ◽

10.1007/s11605-018-4009-1 ◽

2018 ◽

Vol 23 (5) ◽

pp. 895-903 ◽

Cited By ~ 1

Author(s):

Wei-Han Zhang ◽

Kun Yang ◽

Xin-Zu Chen ◽

Ying Zhao ◽

Kai Liu ◽

...

Keyword(s):

Gastric Cancer ◽

Laparoscopic Surgery ◽

Cancer Surgery ◽

Gastric Cancer Surgery

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Previous open gastric surgery is not a contraindication for laparoscopic gastric cancer surgery

Medicine Science | International Medical Journal ◽

10.5455/medscience.2021.08.268 ◽

2022 ◽

Vol 11 (1) ◽

pp. 31

Author(s):

Akile Zengin ◽

Yusuf Bag ◽

Mehmet Aydin ◽

Fatih Sumer ◽

Cuneyt Kayaalp

Keyword(s):

Gastric Cancer ◽

Gastric Surgery ◽

Cancer Surgery ◽

Gastric Cancer Surgery

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Finnish National Esophago-Gastric Cancer Cohort (FINEGO) for studying outcomes after oesophageal and gastric cancer surgery: a protocol for a retrospective, population-based, nationwide cohort study in Finland

BMJ Open ◽

10.1136/bmjopen-2018-024094 ◽

2019 ◽

Vol 9 (1) ◽

pp. e024094 ◽

Cited By ~ 3

Author(s):

Joonas H Kauppila ◽

Pasi Ohtonen ◽

Tuomo J Karttunen ◽

Arto Kokkola ◽

Simo Laine ◽

...

Keyword(s):

Gastric Cancer ◽

Population Based ◽

Poor Quality ◽

Cancer Surgery ◽

High Morbidity ◽

Gastric Cancer Surgery ◽

Improved Outcomes ◽

Secondary Endpoints

IntroductionSurgery for oesophageal and gastric cancers is associated with high morbidity, mortality and poor quality of life postoperatively. The Finnish National Esophago-Gastric Cancer Cohort has been established with the aim of identifying factors that could contribute to improved outcomes in oesophago-gastric cancer.Methods and analysisAll patients with oesophageal and gastric cancer diagnosed in Finland between 1987 and 2015 will be identified from the Finnish national registries. The Finnish Cancer Registry and Finnish Patient Registry will be used to identify patients that fulfil the inclusion criteria for the study: (1) diagnosis of oesophageal, gastro-oesophageal junction, or gastric cancer, (2) any surgical treatment for the diagnosed cancer and (3) age of 18 or over at the time of diagnosis. Clinical variables and complication information will be retrieved in extensive data collection from the medical records of the relevant Finnish hospitals and complete follow-up for vital status from Statistics Finland. Primary endpoint is overall all-cause mortality and secondary endpoints include complications, reoperations, medication use and sick leaves. Sub-studies will be implemented within the cohort to investigate specific populations undergoing oesophageal and gastric cancer surgery. The initial estimated sample size is 1800 patients with surgically treated oesophageal cancer and 7500 patients with surgically treated gastric cancer.Ethics and disseminationThe study has been approved by the Ethical Committee in Northern Ostrobothnia, Finland and The National Institute for Health and Welfare, Finland. Study findings will be disseminated via presentations at conferences and publications in peer-reviewed journals.

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