scholarly journals Accuracy of Fine Needle Aspiration Biopsy (F.N.A.B) in Diagnosis of Breast Lump

2020 ◽  
Vol 15 (2) ◽  
pp. 9-12
Author(s):  
Sarab K. Abedalrahman
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
False Negative ◽  
Needle Aspiration ◽  
Tertiary Hospital ◽  
Aspiration Biopsy ◽  
Test Accuracy ◽  
Breast Lump ◽  
Fine Needle ◽  
Needle Aspiration Biopsy

Background: Breast cancer is the first one among Iraqi females. Most of them present later for diagnosis. Early detection center in tertiary hospital practice uses FNAB for early diagnosis. Publications on accuracy of this detection are scarce. Objective:  To test the accuracy of FNAB in breast lump diagnosis. Methods: Diagnostic test accuracy study, on 204 women with breast lump, attending the oncology department in 2017. Results: Fine-needle aspiration biopsy diagnosis of histologically malignant cases were, malignant in 89 (87.3%), suspicious of malignancy in 5 (4.9%), and benign in 4 (3.9%). Complete sensitivity was 87.3%, and specificity was 100%, with 12.7% false negative results and no false positive cases. The accuracy was 94%.

scholarly journals Reliability of fine needle aspiration biopsy in diagnosis of breast lump

2019 ◽  
Vol 15 (1) ◽  
pp. 61-67
Author(s):  
Sarab K. Abedalrahman
Keyword(s):  
Breast Cancer ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
False Negative ◽  
Screening Method ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Breast Lump ◽  
Fine Needle ◽  
Needle Aspiration Biopsy

Background: breast cancer is commonest cancer globally and the 1st cancer in Iraq among females, its management and prognosis depend on early diagnosis, the traditional method was excisional biopsy which is expensive and invasive leading to delayed diagnosis, FNAB is cheap nom invasive more acceptable to women, Aim of the study: to test the reliability of FNAB in preoperative diagnosis of breast lump. Methodology: This is a retrospective study of 204 cases, 102 breast cancer cases and 102 benign breast lesions, taken between Jan. 2017 – Nov. 2017. The sample taken from the breast cancer early detection center in  Al-Alwiyaa maternity teaching hospital, during the year 2017 Results: Invasive ductal carcinoma (IDC) was found among  82(80.4%) of malignant cases, ILC was 14(13.7%) , fibroadenoma was the most common  benign lesions 51(50%), The absolute sensitivity was 96% , specificity 100%, with 4% false negative the accuracy was 98%. The complete sensitivity was 96%, and specificity was 83%, with 4% false negative and 17% false positive cases, the accuracy was 90%, Conclusion and recommendation: fine-needle aspiration biopsy (FNAB) is accurate for breast lump diagnosis. With high sensitivity and specificity. FNAB is a good screening method and help in an improvement of treatment planning

Pediatric Thyroid Nodules: Disease Demographics and Clinical Management as Determined by Fine Needle Aspiration Biopsy

PEDIATRICS ◽  
1995 ◽  
Vol 95 (1) ◽  
pp. 46-49
Author(s):  
Stephen S. Raab ◽  
Jan F. Silverman ◽  
Tarik M. Elsheikh ◽  
Patricia A. Thomas ◽  
Paul E. Wakely
Keyword(s):  
Fine Needle Aspiration ◽  
Thyroid Nodules ◽  
Fine Needle Aspiration Biopsy ◽  
False Negative ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Benign Nodule ◽  
Fine Needle ◽  
Minimal Invasiveness ◽  
Needle Aspiration Biopsy

Objective. The prevalence of thyroid nodularity in children has been estimated to be 1.8%. The reported prevalence of specific diseases which comprise these nodules is conflicting as evidenced by a reported range of malignancy of 2 to 50% in solitary nodules. In order to better classify pediatric (<18 years old) thyroid disease and evaluate the utility of fine needle aspiration biopsy (FNAB) in this patient population, we retrospectively reviewed 66 FNABs from 64 thyroid nodules and 2 perithyroid lymph nodes from 57 patients. Methodology. Patients: The study was composed of 8 males and 49 females who ranged in age from 1 to 18 years old (mean = 13.1). Design: Surgical and/or clinical follow-up was obtained in all patients. The 66 FNAB diagnoses were initially classified into specific diseases. However, for the purpose of this review, the cases were classified as: 3 insufficient, 51 benign, 8 suspicious, and 4 malignant. Results. There were no "false positives" and one "false negative" (a papillary carcinoma was misdiagnosed as a benign nodule). Overall, 10 patients (18%) had malignant thyroid lesions, including 8 papillary carcinomas and 2 follicular carcinomas. Benign diagnoses included benign nodule, cyst, lymphocytic thyroiditis, granulomatous thyroiditis, hyperplasia, and abscess. Conclusions. The prevalence of malignancy in pediatric patients with thyroid nodules was 18%. We conclude that, because of its high diagnostic accuracy and minimal invasiveness, FNAB is useful in the management of pediatric thyroid nodules.

Ultrasonically Guided Fine-Needle Aspiration Biopsy in Focal Pancreatic Lesions

1987 ◽  
Vol 28 (5) ◽  
pp. 541-543 ◽  
Author(s):  
M. Taavitsainen ◽  
A. Koivuniemi ◽  
S. Bondestam ◽  
L. Kivisaari ◽  
E. Tierala
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
False Negative ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Solid Mass ◽  
Pancreatic Lesion ◽  
Fine Needle ◽  
Malignant Case ◽  
Needle Aspiration Biopsy

Ultrasonically guided fine-needle aspiration biopsy was performed in 100 patients with a focal pancreatic lesion. The lesion was a well-defined solid mass of 1 to 4 cm in 37 cases, a well-defined solid mass of 4.5 to 10 cm in 28 cases, an intrapancreatic cystic lesion in 23 cases, and an ill-defined prominent area in 12 cases. The samples were taken with a one-hand instrument and 0.7 to 0.9 mm disposable needles without a puncture adaptor. The material was sufficient for cytologic analysis in 98 cases. Malignant cells were obtained in 44 of the 49 cases with pancreatic carcinoma and lymphoma cells in one case with lymphomatous infiltration. Four of the six cases of cystadenoma could be identified cytologically. In solid inflammatory lesions, the nature of the lesion was seen in 12 of the 17 cases. There were no false positive reports of malignancy. The solid prominent areas of normal pancreatic tissue yielded normal cytologic samples. Aspirates of cystic lesions in the pancreas revealed one malignant case, and infected lesions could be differentiated from ***non-infected in the rest. There was one complication in a patient with an obstructed and dilated common bile duct. The aspiration procedure caused severe pain and the operation was performed earlier than scheduled. Diagnostic material is obtained in the majority of ultrasound guided aspiration biopsies of the pancreas. In malignancy, false negative results occur in about 10 per cent of cases.

Application Value of Ultrasound-Guided Fine Needle Aspiration Cytological Examination and Ultrasound Evaluation

2021 ◽  
Vol 11 (7) ◽  
pp. 1852-1860
Author(s):  
Jingcheng Zhang ◽  
Jili Chen ◽  
Juanjuan Li ◽  
Xuechen Yang
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
False Negative ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Maximum Diameter ◽  
Ultrasound Guided ◽  
Fine Needle ◽  
Negative Results ◽  
Needle Aspiration Biopsy

In this paper, chronic inflammatory cell infiltration was seen during this period. The reason for the false-positive result may be the atypical proliferation of cells caused by chronic inflammatory stimulation with malignant cytology. 12 cases of false negative results, including 2 cases of type I nodules, 10 cases of type III nodules, postoperative histology and pathology were papillary carcinoma, there are many reasons for false negative results, including the size of the nodules, the puncture operator, the technical level, internal tissue composition and properties of the nodules all affect the accuracy of puncture and cytopathology results. The satisfaction of puncture specimens of each group was calculated and compared. For thyroid nodules with the maximum diameter ≤5 mm, the satisfaction rate of puncture specimens was 87.2%, and the diagnostic sensitivity and accuracy of ultras guided fine needle aspiration biopsy were relatively low. Cytological results were in poor agreement with postoperative histological and pathological results, so it was recommended to take active follow-up for thyroid nodules with the maximum diameter ≤5 mm to reduce unnecessary puncture. The overall puncture success rate is relatively high, ≤10 mm low-echo nodules or even ≤5 mm nodules can be cytological puncture, especially the kind of close to the capsule, trachea and recurrent laryngeal nerve nodules, for the largest diameter of >5 mm, the satisfaction rate of puncture specimens is relatively high is 93.2%. Moreover, the sensitivity and accuracy of ultrasound guided fine needle aspiration biopsy were relatively high, and the cytological results were in good agreement with the postoperative histological and pathological results. Therefore, it was feasible to confirm the diagnosis of suspected malignant nodules by ultrasound. The diagnostic in each group and the consistency between cytological diagnosis and histological diagnosis were analyzed by comparing the histological and pathological results after surgery. Ultrasound-guided fine needle aspiration biopsy can be used more effectively in clinical practice.

Diagnosis and Subclassification of Breast Carcinoma by Fine-Needle Aspiration Biopsy

2002 ◽  
Vol 126 (12) ◽  
pp. 1453-1457 ◽  
Author(s):  
Nancy A. Young ◽  
Dina R. Mody ◽  
Diane D. Davey
Keyword(s):  
Breast Carcinoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
False Negative ◽  
False Negative Rate ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Ductal Adenocarcinoma ◽  
Fine Needle ◽  
Needle Aspiration Biopsy

Abstract Context.—The College of American Pathologists Interlaboratory Comparison Program in Non-Gynecologic Cytopathology is a popular educational program for nongynecologic cytology that had 1018 participating laboratories by the end of 2000. Data generated from this program allow for tracking performance on slides in a diverse group of laboratories. Objective.—We reviewed the performance of participating laboratories on fine-needle aspiration biopsies of the breast with particular interest in the ability of participants to accurately subclassify breast carcinoma. Design.—We reviewed the responses of participating laboratories for glass slides of breast fine-needle aspiration biopsies for the year 2000. We analyzed benchmarking data provided for each specific diagnosis. Results.—The overall false-negative rate for laboratories was 6.2%, and the overall false-positive rate was 1.1%. Most of the breast carcinomas were correctly identified as malignant on the general diagnosis, but participants had more difficulty subclassifying types of breast carcinoma. The rate of correct exact diagnosis was 65% for ductal adenocarcinoma, 20% for lobular adenocarcinoma, 12% for medullary carcinoma, and 27% for mucinous carcinoma. Conclusions.—This study shows that fine-needle aspiration biopsy of the breast is a reliable method for the diagnosis of breast carcinoma, but difficulties still exist in our ability to determine tumor subtype.

scholarly journals The fine-needle aspiration biopsy efficacy of small thyroid nodules in the area of recently normalized iodine supply

2008 ◽  
Vol 159 (6) ◽  
pp. 747-754 ◽  
Author(s):  
Dorota Słowińska-Klencka ◽  
Bożena Popowicz ◽  
Andrzej Lewiński ◽  
Stanisław Sporny ◽  
Mariusz Klencki
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
Histopathological Examination ◽  
False Negative ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Fine Needle ◽  
Iodine Supply ◽  
Needle Aspiration Biopsy ◽  
Thyroid Lesions

ObjectiveTo evaluate the incidence of focal lesions in the thyroid in the area of recently normalized iodine supply as well as to compare the efficacy of fine-needle aspiration biopsy (FNAB) of small (infracentimetric) and large thyroid lesions in this area.MethodsThe outcomes of 13 646 ultrasound (US) examinations, 13 437 US-guided FNABs of the thyroid and 1694 results of post-operative histopathological examinations were analysed.ResultsInfracentimetric nodules (INs ≤10 mm) were revealed by US examinations in 43.5% of patients; in the majority of the cases (82.2%) INs were multiple. The percentage of revealed carcinomas by aspiration of INs is similar to that observed when large nodules (LNs >10 mm) are examined cytologically. However, the efficiency of preoperative diagnosis of INs is lower than LNs with respect to both US selection of lesions for FNAB and the percentage of false negative results of FNAB (29.8 vs 5.4%, P<0.001). In post-operative histopathological examination, extrathyroidal extension of thyroid cancers was observed in nearly 30% of microcarcinomas.ConclusionsIn endemic or post-endemic areas, the efficiency of FNAB is lower in the case of small lesions than larger ones. In spite of this, the percentage of cytologically revealed carcinomas among small lesions is not lower than larger ones. Thus, it is particularly indicated to follow up small thyroid lesions with repeated US examinations in such areas.

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