Single Intrauterine Fetal Demise in Twin Pregnancies and Pregnancy Outcomes

Objective:The objective of this study was to observe pregnancy outcomes in mice infected transvaginally withChlamydia trachomatis.Methods:Pregnant mice were inoculated transvaginally with eitherC. trachomatis(CT) or sterile calf serum (CON) on pregnancy day 4. Pregnancy outcomes as well as genital tract histology and culture were compared. Statistical analysis was performed using Fisher's exact test and Student's t-test.Results:Twenty-four of 26 CT mice had positive uterine cultures forC. trachomatis.Inflammation occurred in 9 (34.6%) (P= 0.002, 95% confidence interval = 1.7–3.5) and intrauterine fetal demise occurred in 5 (19.2%) (P= 0.05, 95% confidence interval = 1.6–2.9) of CT mice. No mice in the CON group (0/24) had positive uterine cultures, developed inflammation, or experienced intrauterine fetal demise.Conclusions:Lower genital tract chlamydial infection is associated with intrauterine fetal demise in Swiss-Webster mice.

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Assesment of pregnancy outcomes among twin pregnancies with single fetal demise regarding chorionicity and fetal death time

Journal of the Turkish-German Gynecological Association ◽

10.4274/jtgga.galenos.2018.2018.0053 ◽

2019 ◽

Vol 20 (3) ◽

pp. 147-153

Author(s):

Sevcan Arzu Arınkan ◽

Resul Arısoy ◽

Murat Api

Keyword(s):

Pregnancy Outcomes ◽

Fetal Death ◽

Fetal Demise ◽

Death Time ◽

Twin Pregnancies

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Obstetric outcome in twin pregnancies complicated with single intrauterine fetal demise

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20202747 ◽

2020 ◽

Vol 9 (7) ◽

pp. 2998

Author(s):

Priyanka Chaudhari ◽

Vinita Gupta ◽

Anshu Sharma ◽

Archna Tandon ◽

Namrata Saxena ◽

...

Keyword(s):

Gestational Age ◽

Mode Of Delivery ◽

Intrauterine Fetal Death ◽

Fetal Mortality ◽

Delivery Mode ◽

Fetal Demise ◽

Maternal Risk ◽

Monochorionic Twin ◽

Intrauterine Fetal Demise ◽

Twin Pregnancies

Background: It has been reported that single intrauterine fetal death in twin pregnancy occurs in 3.7-6.8% all twin pregnancies. The objective of this study was to evaluate the maternal and fetal demographic features and feto-maternal outcomes in twin pregnancies complicated with single intrauterine fetal demise and evaluation of available management guidelines.Methods: This retrospective study was conducted at obstetrics and gynecology department of SGRRIM and HS, Dehradun, Uttarakhand between January 2015 and December 2019. There was a total of 182 twin deliveries at study hospital during this period and 35 of these cases were complicated with single intrauterine fetal demise. Maternal age, parity, chorionicity of twin gestation, gestational age at single intrauterine fetal demise, gestational age at delivery, mode of delivery, birth weight, Apgar Score at birth, neonatal intensive care unit stay of newborn, maternal fibrinogen levels during pregnancy and delivery time and associated obstetric complications were analyzed in these cases of single intrauterine fetal demise with twin gestation. All monochorionic twin pregnancies were included in the study Group A and dichorionic twin in Group B.Results: The mean age of 32 patients included in study was 29.7±4.6 years. Twenty (62.5%) of these patients were dichorionic and 12 (37.5%) of these were monochorionic twin gestation. Single intrauterine fetal demise occurred in first trimester in 8 (25%) patients, during the second trimester 20 (62.5%) and 4 (12.5%) patients had third trimester single intrauterine fetal demise. Preterm deliveries occurred in 18 (56.3%) of patients and 8 (44.4%) of patients were of monochorionic and 10 (55.6%) of dichorionic twin patients. Among thirty-two patients, 11 (34.4%) patients had caesarean delivery and 21 (65.6%) patient had vaginal birth. No maternal or fetal mortality noted and none of the patients had maternal coagulation disorder.Conclusions: This study indicates that in cases of twin pregnancies with single fetal intrauterine demise with individualized management plan at higher centre and close maternal and fetal surveillance live fetus can be saved without any maternal risk.

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Twin pregnancies obtained with in vitro fertilization and embryo transfer and spontaneous pregnancy: a comparison of pregnancy outcomes

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2012.00694 ◽

2013 ◽

Vol 32 (6) ◽

pp. 694-695

Author(s):

Xue-feng HU

Keyword(s):

Embryo Transfer ◽

Pregnancy Outcomes ◽

Spontaneous Pregnancy ◽

Twin Pregnancies

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Florid Bacillus cereus Infection of the Placenta Associated With Intrauterine Fetal Demise

Pediatric and Developmental Pathology ◽

10.1177/1093526621999026 ◽

2021 ◽

pp. 109352662199902

Author(s):

Stephanie Shea ◽

Alberto Paniz-Mondolfi ◽

Emilia Sordillo ◽

Michael Nowak ◽

Fumiko Dekio

Keyword(s):

Bacillus Cereus ◽

Placental Tissue ◽

Maternal Blood ◽

Gastrointestinal Infections ◽

Gram Positive ◽

Fetal Demise ◽

Placental Infection ◽

Intrauterine Fetal Demise ◽

Acute Necrotizing ◽

Poor Outcomes

Bacillus cereus is a gram-positive, rod-shaped bacterium that is commonly implicated in foodborne illness but has also become increasingly recognized as a source of serious non-gastrointestinal infections, including sepsis, meningitis, and pneumonia. Non-gastrointestinal B. cereus infections have been identified in children, especially in neonates; however, there are no previously described cases of fetal demise associated with B. cereus placental infection. We present a case of acute chorioamnionitis-related intrauterine fetal demise of twin A at 17 weeks gestation, noted two days after selective termination of twin B. Histological examination revealed numerous gram-positive bacilli in placental tissue, as well as fetal vasculature, in the setting of severe acute necrotizing chorioamnionitis and subchorionitis, intervillous abscesses, acute villitis, and peripheral acute funisitis. Cultures of maternal blood and placental tissue both yielded growth of B. cereus. This case underscores the importance of B. cereus as a human pathogen, and specifically demonstrates its potential as an agent of severe intraamniotic and placental infection with poor outcomes for the fetus.

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