Pregnancy and Uterine Anomalies

ABSTRACT Congenital uterine malformations are known to have a higher incidence of infertility, repeated first trimester spontaneous miscarriages, fetal intrauterine growth restriction, fetal malposition, preterm labor, retained placenta and increased cesarean section rate. The actual incidence of uterine malformation is unknown, since many women do not have any symptoms. They are estimated to occur in 0.4% (0.1-3%) of the general population and in 4% of infertile women, and in patients with repeated spontaneous miscarriages the figures fluctuate between 3 and 38%. The discrepancy among different publications stems from their use of different diagnostic techniques, heterogenous population samples and clinical diversity of Mullerian anomalies.

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Pregnancy Outcome in Uterine Anomalies

The Journal of Medical Sciences ◽

10.5005/jp-journals-10045-0052 ◽

2017 ◽

Vol 3 (1) ◽

pp. 31-33

Author(s):

Nagendra Prasad ◽

James Thingujam

Keyword(s):

Retrospective Study ◽

Pregnancy Outcome ◽

Pregnancy Outcomes ◽

Intrauterine Growth Restriction ◽

Preterm Labor ◽

Premature Rupture ◽

Intrauterine Growth ◽

Preterm Premature Rupture ◽

Uterine Anomalies ◽

Uterine Anomaly

ABSTRACT Maternal with congenitial anomalies are known to have higher incidence of infertility, intrauterine growth restriction, fetal malposition, preterm labor, preterm premature rupture of membrane and increased cesaerean section rate. Study Design This is retrospective study, the pregnancies with uterine anomaly confirmed by ultrasound between Jan 2016 to jan 2017 at our hospital was taken and its outcome is observed. Reults The majority of preterm delivery in our study are mainly associated with septate and bicornuate uterus. Cesaerean section comprised of 80% and its major indication is due to fetal malpresentation (breech). Thus Pregnancy outcomes of individual depending on the type of uterine anomalies. How to cite this article Nagarathnamma R, James T, Prasad N. Pregnancy Outcome in Uterine Anomalies. J Med Sci 2017;3(1):31-33.

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Single Fetal Demise in Twin Pregnancy—A Great Concern but Still a Favorable Outcome

Diseases ◽

10.3390/diseases9020033 ◽

2021 ◽

Vol 9 (2) ◽

pp. 33

Author(s):

Bogdan Ioan Stefanescu ◽

Ana-Maria Adam ◽

Georgiana Bianca Constantin ◽

Constantin Trus

Keyword(s):

Intrauterine Growth Restriction ◽

Preterm Labor ◽

Twin Pregnancy ◽

First Trimester ◽

Neurological Complications ◽

Third Trimester ◽

Fetal Demise ◽

Assisted Reproduction Techniques ◽

Intrauterine Growth ◽

Frequent Use

The incidence of multiple pregnancies has increased in the last decades, mostly explained by the more frequent use of ovulation induction drugs and assisted reproduction techniques. Although single fetal death in the first trimester of twin pregnancy is not an uncommon event nor does it have serious consequences on the survival fetus, the death of one fetus in the second or third trimester of pregnancy is associated with a serious increase in morbidity and mortality for the surviving co-twin. Preterm labor, preeclampsia, intrauterine growth restriction (IUGR), neurological complications or even the death of the surviving twin have been associated with single fetal demise after mid gestation. We present a very rare case of twin pregnancy with single fetal demise at 26 weeks of gestation successfully managed to term.

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Is ProBNP a New Marker for Predicting Intrauterine Growth Restriction?

Zeitschrift für Geburtshilfe und Neonatologie ◽

10.1055/a-1382-8787 ◽

2021 ◽

Vol 225 (02) ◽

pp. 125-128

Author(s):

Hasan Eroğlu ◽

Nazan Vanlı Tonyalı ◽

Gokcen Orgul ◽

Derya Biriken ◽

Aykan Yucel ◽

...

Keyword(s):

Intrauterine Growth Restriction ◽

Final Analysis ◽

First Trimester ◽

Maternal Serum ◽

Growth Restriction ◽

Control Group ◽

Aneuploidy Screening ◽

Intrauterine Growth ◽

Potential Marker ◽

The Mean

Abstract Purpose To evaluate the usability of first-trimester maternal serum ProBNP levels in the prediction of intrauterine growth restriction (IUGR). Methods In this prospective study, blood samples taken from 500 women who applied to our polyclinic for routine serum aneuploidy screening between the 11–14th gestational weeks were centrifuged. The obtained plasma samples were placed in Eppendorf tubes and stored at −80+°C. For the final analysis, first-trimester maternal serum ProBNP levels of 32 women diagnosed with postpartum IUGR and 32 healthy women randomly selected as the control group were compared. FGR was defined as estimated fetal weight below the 10th percentile for the gestational age. Results The mean ProBNP levels were statistically and significantly higher in the women with intrauterine growth restriction (113.73±94.69 vs. 58.33±47.70 pg/mL, p<0.01). At a cut-off level of 50.93, ProBNP accurately predicted occurrence of IUGR (AUC+= 0.794 (95% confidence interval 0.679–0.910), p+= 0.001) with sensitivity and specificity rates of 78.1 and 69.0%, respectively. Conclusion First-trimester serum ProBNP level was significantly higher in women who developed IUGR compared to healthy controls. First-trimester ProBNP level can be used as a potential marker to predict the development of IUGR in pregnant women.

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First trimester uterine artery Doppler and subsequent intrauterine growth restriction and preterm birth

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2004.09.085 ◽

2004 ◽

Vol 191 (6) ◽

pp. S22

Author(s):

Lorraine Dugoff ◽

John Hobbins ◽

Vincent Faber ◽

Fergal Malone ◽

Michael Belfort ◽

...

Keyword(s):

Preterm Birth ◽

Intrauterine Growth Restriction ◽

Uterine Artery ◽

First Trimester ◽

Growth Restriction ◽

Uterine Artery Doppler ◽

Intrauterine Growth

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First trimester uterine artery Doppler abnormalities predict subsequent intrauterine growth restriction

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2005.06.054 ◽

2005 ◽

Vol 193 (3) ◽

pp. 1208-1212 ◽

Cited By ~ 67

Author(s):

Lorraine Dugoff ◽

Anne M. Lynch ◽

Darleen Cioffi-Ragan ◽

John C. Hobbins ◽

Lisa K. Schultz ◽

...

Keyword(s):

Intrauterine Growth Restriction ◽

Uterine Artery ◽

First Trimester ◽

Growth Restriction ◽

Uterine Artery Doppler ◽

Intrauterine Growth

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First trimester screening for pre-eclampsia and intrauterine growth restriction using three-dimensional Doppler angiography (SPIRIT): protocol for a multicentre prospective study in nulliparous pregnant women

BMJ Open ◽

10.1136/bmjopen-2020-037751 ◽

2020 ◽

Vol 10 (10) ◽

pp. e037751

Author(s):

Charline Bertholdt ◽

Gabriela Hossu ◽

Claire Banasiak ◽

Marine Beaumont ◽

Olivier Morel

Keyword(s):

Pregnant Women ◽

Intrauterine Growth Restriction ◽

Power Doppler ◽

First Trimester ◽

Growth Restriction ◽

Flow Index ◽

Intrauterine Growth ◽

Uncomplicated Pregnancy ◽

Nulliparous Women ◽

Biomarker Analysis

IntroductionPre-eclampsia (PE) and intrauterine growth restriction (IUGR) are two major pregnancy complications, related to chronic uteroplacental hypoperfusion. Nowadays, there is no screening or diagnostic test for uteroplacental vascularisation deficiency in pregnant women. Since 2004, 3 three-imensional power Doppler (3DPD) angiography has been used for the evaluation of uteroplacental vascularisation and three vascular indices are usually calculated: Vascularisation Index (VI), Flow Index (FI) and vascularisation-FI (VFI). A high intraobserver and interobserver reproducibility and a potential interest for placental function study were reported by our team and others.The main objective of our study is to determine differences in 3DPD indices at first trimester between pregnancies defined at their outcome as uncomplicated pregnancy, PE (mild and severe) and IUGR in nulliparous women.Methods and analysisThis is a national multicentre prospective cohort study conducted in four French maternity units. We expect to include 2200 women in a period of 36 months. The nulliparous pregnant women will be recruited during their first trimester consultation (11–13+6 gestation week (GW)).The 3DPD and uterine artery Doppler acquisition will be included in the current routine 11–13+6 GW ultrasound. Also, additional blood samples will be taken for biomarker analysis (PAPP-A and P1GF) and biological collection. Uteroplacental VIs (FI and VFI) will be measured. For each subgroup (uncomplicated pregnancy, PE and IUGR), mean values in 3DPD indices will be computed and compared using a pairwise t test with a Bonferroni correction p value adjustment.Ethics and disseminationThe study was approved by the French Ethics Committee, the Comité de Protection des Personnes SUD MEDITERRANEE IV on 13 February 2018 with reference number 17 12 03. The results of this study will be published in a peer-reviewed journal and will be presented at relevant conferences.Trial registration numberNCT03342014; Pre-results. PHRCN-16-0567.

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