Oral Lichen Planus–A Brief Review on Treatment Modalities

Background: Oral Lichen Planus (OLP) is one of the most common dermatological disease which is present in the oral cavity. It is a chronic autoimmune, mucocutaneous disease that affects oral mucosa as well as the skin, genital mucosa and other sites of the body.Method: In this review study, various databases such as Google Scholar, PubMed Central, Hinari and Cochrane library were searched for articles with keywords lichen planus, oral lichen planus, premalignant lesions, management of Lichen planus. Articles were searched from January 2015 to 5th November 2020.Result: From the 34 articles obtained after reviewing the abstracts, most relevant 32articles were evaluated in this study.Conclusion: The etiology, pathophysiology, clinical presentation, histopathological features, diagnosis and various management for oral lichen planus is discussed. This article also compares the existing and the most recent treatment modalities that are available throughout the world that are discussed in the literatures. However, more intensive studies must be carried out to find the best treatments which are cost-effective in the long run. Update Dent. Coll. j: 2020; 10 (2): 29-34

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Triamcinolone acetate vs. combination of triamcinolone acetate and isotretinoin in treatment of oral lichen planus: a comparative study

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20181870 ◽

2018 ◽

Vol 4 (3) ◽

pp. 776 ◽

Cited By ~ 1

Author(s):

Smruti Swain ◽

Sruthi T. Radhakrishnan ◽

Saroj K. Panigrahi ◽

Manas R. Biswal

Keyword(s):

Combination Therapy ◽

Lichen Planus ◽

Complete Resolution ◽

Oral Lichen Planus ◽

Lesion Size ◽

Treatment Modalities ◽

Chi Square ◽

Group A ◽

Group B ◽

Oral Lichen

Background: There are many treatment modalities being practiced for oral lichen planus and many are under trial. However, none has been able to provide a complete permanent cure. This study aims to see if combination therapy with topical triamcinolone acetate and isotretinoin is superior to topical triamcinolone acetate alone, in treating oral lichen planus.Methods: Patients were randomly divided into 2 groups to receive either triamcinolone (0.5%) only (group A) or 0.5% triamcinolone with 0.1% isotretinoin (group B). Patients applied medication thrice daily and were followed up at, 2 week, 1st month, 2nd month and 3rd months. Size of lesion and symptoms were assessed at each visit. The data was analysed by chi square test. Results: Patients in group B (combination therapy) showed significantly better improvement in symptoms at the end of 2nd week and 1st month as compared to group A. Decrease in lesion size was also better in group B with p values of 0.012, 0.004 and 0.022 at 2 weeks, 1st month and 2nd month respectively. Complete resolution of lesion was obtained in 53.33% people in group B and 26.67% people in group A.Conclusions: Combination of 0.5% triamcinolone acetate and 0.1% isotretinoin is superior to 0.5% triamcinolone acetate alone in treatment of oral lichen planus. It causes quicker relief in symptoms and decreases lesion size faster. Complete resolution of the lesions is also more when combination therapy is used.

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Treatment modalities of oral lichen planus: an update

JORDI - Journal of Oral Diagnosis ◽

10.5935/2525-5711.20160003 ◽

2016 ◽

Vol 1 ◽

Author(s):

Santosh Patil ◽

Suneet Khandelwal ◽

Nidhi Sinha ◽

Sumita Kaswan ◽

Farzan Rahman ◽

...

Keyword(s):

Lichen Planus ◽

Oral Lichen Planus ◽

Treatment Modalities ◽

Oral Lichen

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The Therapy of Oral Lichen Planus

Critical Reviews in Oral Biology & Medicine ◽

10.1177/10454411930040020101 ◽

1993 ◽

Vol 4 (2) ◽

pp. 141-158 ◽

Cited By ~ 62

Author(s):

Drore Eisen

Keyword(s):

Lichen Planus ◽

Emotional Stress ◽

Oral Lichen Planus ◽

Alternative Therapies ◽

Treatment Modalities ◽

Medical Treatments ◽

Drug Eruptions ◽

The Many ◽

Treat All ◽

Oral Lichen

Oral lichen planus is a chronic mucocutaneous disease that is relatively common. Although many patients are asymptomatic and require no therapy, those who exhibit atrophic and erosive lesions are often a challenge to treat. All therapies are palliative, and none is effective universally. Currently employed treatment modalities include corticosteroids administered topically, intralesionally, or systemically. Alternative therapies include topical and systemic retinoids, griseofulvin, Cyclosporine, and surgery. Other medical treatments and experimental modalities, including mouth PUVA, have been reported to be effective. Controversy concerning the efficacy of all these treatments suggests that oral lichen planus is a heterogeneous disorder. Eliminating lichenoid drug eruptions, candidiasis, trauma, contact mucositis, and emotional stress may play a role in the management of these patients. This article is a review of the many treatments and measures that have been employed in the management of patients with oral lichen planus.

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