Possibilities of 3D Ultrasound and 3D Power Doppler Imaging in Ovarian Cancer Screening Tests

Object. Three-dimensional (3D) power Doppler ultrasonography imaging provides a rapid, noninvasive visualization of ruptured intracranial aneurysms, including their relationship to other vascular structures. Methods. The authors used transcranial 3D power Doppler imaging in the emergency room to examine patients with acute subarachnoid hemorrhage. In all patients, the ruptured aneurysm was rapidly located with 3D power Doppler imaging. Conventional x-ray angiography confirmed both the ultrasonography-based diagnosis and the location of aneurysmal bleeding. Conclusions. These preliminary results indicate that 3D power Doppler imaging is a rapid, noninvasive screening method for the visualization of ruptured aneurysms.

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Feasibility Study of a Randomised Trial of Ovarian Cancer Screening among the General Population

Journal of Medical Screening ◽

10.1177/096914139400100404 ◽

1994 ◽

Vol 1 (4) ◽

pp. 209-214 ◽

Cited By ~ 25

Author(s):

C A Parkes ◽

D Smith ◽

N J Wald ◽

T H Bourne

Keyword(s):

Breast Cancer ◽

Ovarian Cancer ◽

Cancer Screening ◽

Breast Cancer Screening ◽

Screening Test ◽

False Positive Rate ◽

Randomised Trial ◽

Doppler Imaging ◽

Colour Doppler ◽

Ovarian Cancer Screening

To determine the feasibility of a randomised trial of ovarian cancer screening among women attending a breast cancer screening centre. Randomised controlled trial of ovarian cancer screening using transvaginal ultrasonography as a primary screening test and colour Doppler imaging as a secondary screening test in the screened group and no intervention in the control group. Reading breast cancer screening centre (United Kingdom). 8678 women, without a bilateral oophorectomy or hysterectomy, aged between SO and 64 attending for NHS breast cancer screening between September 1989 and February 1993. Uptake of ovarian cancer screening among eligible women and the screening false positive rate (considered as the referral rate to a gynaecologist for surgical intervention). −82% (7124/8678) of eligible women agreed to join the trial and were randomly allocated in equal numbers to each arm of the trial. 3280 women had an initial scan. The false positive rate after ultrasonography alone was 2·9% (86/2952), but this dropped to 0·5% after colour Doppler as a secondary screening test. One stage I primary ovarian cancer was detected at screening in a 58 year old women. A randomised trial of ovarian cancer screening using ultrasonography and colour Doppler imaging is feasible and acceptable among women attending a breast cancer screening centre. The results indicate that the expected odds of being affected given a positive result in the general population would be about 1:12. A full randomised trial of ovarian cancer screening with mortality as the end point is needed to assess whether screening reduces mortality from this disease. A multicentre European trial is currently in progress.

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