Perfluorocarbon Liquids in Vitreoretinal Surgery

2013 ◽  
pp. 795-795
Author(s):  
Amar Agarwal
Keyword(s):  
Vitreoretinal Surgery ◽  
Perfluorocarbon Liquids

scholarly journals Perfluorocarbon Liquid: Its Application in Vitreoretinal Surgery and Related Ocular Inflammation

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Qi Yu ◽  
Kun Liu ◽  
Li Su ◽  
Xin Xia ◽  
Xun Xu
Keyword(s):  
Animal Studies ◽  
Vitreoretinal Surgery ◽  
Complete Removal ◽  
Intraocular Lenses ◽  
Perfluorocarbon Liquid ◽  
Potential Toxicity ◽  
The Past ◽  
Perfluorocarbon Liquids

The application of perfluorocarbon liquids has been well acclaimed in vitreoretinal surgery. Its unique physical properties make it an ideal intraoperative tool to improve the efficiency and safety of surgical procedures in complicated cases. The main functions of perfluorocarbon liquids in vitreoretinal surgery include relocating and fixing the detached retina, displacing the subretinal and subchoroidal to fluid anteriorly, revealing proliferative vitreous retinopathy (PVR) for further maneuvers, protecting the macula from exposure to chemicals with potential toxicity, and assisting the removal of foreign body. The related clinical applications include retinal detachment with severe proliferative vitreoretinopathy, giant tear, diabetic retinopathy (DR), retinopathy of prematurity (ROP), and posterior dislocated crystalline and intraocular lenses. The application of perfluorocarbon liquids has been expended over the past fewer years. Several PFCLs related ocular inflammations have been observed inin vitrostudies, animal studies, and clinical follow-up. The complete removal of PFCLs is recommended at the end of the surgery in most cases.

Perfluorocarbon liquids in vitreoretinal surgery: a review of applications and toxicity

2011 ◽  
Vol 30 (4) ◽  
pp. 251-262 ◽  
Author(s):  
Ilias Georgalas ◽  
Ioannis Ladas ◽  
Ioannis Tservakis ◽  
Sergios Taliantzis ◽  
Eustratios Gotzaridis ◽  
...  
Keyword(s):  
Vitreoretinal Surgery ◽  
Perfluorocarbon Liquids

scholarly journals Inflammation Induced by Perfluorocarbon Liquid: Intra- and Postoperative Use

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Marta S. Figueroa ◽  
Diego Ruiz Casas
Keyword(s):  
Inflammatory Reaction ◽  
Histological Analysis ◽  
Experimental Studies ◽  
Vitreoretinal Surgery ◽  
Endothelial Damage ◽  
Perfluorocarbon Liquid ◽  
Anatomical Changes ◽  
Perfluorocarbon Liquids ◽  
Corneal Toxicity

Perfluorocarbon liquids (PFCLs) are useful and safe surgical tools in vitreoretinal surgery. The use of PFCL as a tamponade has been controversial due to the corneal toxicity, retinal infiltration, and inflammatory reaction in experimental studies. Several authors have studied in humans the anatomical and functional outcome and adverse effects of perfluorocarbon liquids used as short-, medium-, and long-term tamponade. PFCLs develop dispersion a few days after injection and droplets may move into the anterior chamber and cause corneal endothelial damage. When PFCLs are used as postoperative tamponades for more than one week, a foreign-body inflammatory reaction is observed in up to 30% of cases but such a reaction does not induce PVR, and it resolves after removal of PFCLs. Although most clinical studies have found no signs of retinal toxicity such as progressive visual acuity deterioration or macular anatomical changes, few performed ERG or retinal histological analysis.

scholarly journals Efficacy and Safety of Vitrectomy without Using Perfluorocarbon Liquids and Drainage Retinotomy Associated with Postoperative Positioning Based on Residual Subretinal Fluid for Rhegmatogenous Retinal Detachment

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Paolo Chelazzi ◽  
Claudia Azzolini ◽  
Claudia Bellina ◽  
Francesca Cappelli ◽  
Ilaria Del Genovese ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Surgical Procedure ◽  
Rhegmatogenous Retinal Detachment ◽  
Intraoperative Complications ◽  
Subretinal Fluid ◽  
Vitreoretinal Surgery ◽  
Perfluorocarbon Liquids ◽  
Secondary Endpoints ◽  
Encircling Band ◽  
Pars Plana

Medical records of 75 eyes from 75 consecutive patients with uncomplicated rhegmatogenous retinal detachment (RRD) who underwent pars plana vitrectomy (PPV) were analyzed. Inclusion criteria were patients with RRD who underwent primary 23- or 25-gauge PPV with air, gas, or SiO tamponade and performed by a single surgeon, no use of perfluorocarbon liquids (PFCL) and drainage retinotomy, and follow-up ≥ six months. Exclusion criteria were patients who underwent previous vitreoretinal surgery, proliferative vitreoretinopathy (PVR) more than grade B, giant tears, and encircling band associated with PPV. The main endpoint was the anatomical retinal reattachment rate after a single surgical procedure. Secondary endpoints were best-corrected visual acuity (BCVA), postoperative retinal displacement, and intraoperative and/or postoperative complications. Primary anatomical success was achieved in 97.3% of cases using this modified surgical procedure. Retinal slippage occurred only in 28.2% of patients and it was not observed in all cases of macula-on RRD. The mean logMAR of the BCVA significantly improved in 92% of patients and no intraoperative complications were observed. The results suggest that complete subretinal liquid drainage is not mandatory for all RRD cases treated with PPV and that using PFCL and performing a drainage retinotomy are not essential in eyes with primary RRD and PVR less than grade B. Postoperative positioning after PPV for uncomplicated RRD based on the presence or absence of residual subretinal fluid at the end of surgery could limit the occurrence of postoperative retinal displacement, while promoting patient compliance.

Perfluorocarbon Liquids in Vitreoretinal Surgery

2019 ◽  
pp. 168-171
Keyword(s):  
Surface Tension ◽  
Retinal Detachment ◽  
High Surface ◽  
Vitreoretinal Surgery ◽  
Hydrogen Atoms ◽  
Ocular Tissues ◽  
High Surface Tension ◽  
Single Piece ◽  
Perfluorocarbon Liquids

Perfluorocarbon (PFC) liquids are hydrocarbons in which all the hydrogen atoms are replaced with the fluorine atoms. PFC liquids are stabilized liquids that can stay as a single piece with their high surface tension and are heavier than water. Perfluoro-n-octane, perfluorodecalin, perfluoro-phenanthrene are frequently used liquid PFC derivatives used in a clinical ophthalmology practice. Intraoperative use of PFC liquids in vitreoretinal surgery for proliferative vitreoretinopathy and complicated retinal detachment provides surgical ease and increase anatomical and functional success. Long-term exposure to PFC liquids results in complications such as inflammation and degenerations of ocular tissues. Studies are needed for PFC liquids which are suitable for long-term intraocular use.

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