Management of Nonobstructive Azoospermia

2014 ◽  
pp. 265-265
Author(s):  
Ibrahim Fahmy ◽  
Ahmed El-Guindi
Keyword(s):  
Nonobstructive Azoospermia

84: A Decision Analysis of Treatments for Nonobstructive Azoospermia Associated with Varicocele

2007 ◽  
Vol 177 (4S) ◽  
pp. 29-30
Author(s):  
Richard Lee ◽  
Mark A. Callahan ◽  
Glen Schattman ◽  
Philip S. Li ◽  
Marc Goldstein ◽  
...  
Keyword(s):  
Decision Analysis ◽  
Nonobstructive Azoospermia

A rare Y-autosome translocation found in a patient with nonobstructive azoospermia: Case report

2021 ◽  
pp. 1-7
Author(s):  
Anita Barišić ◽  
Alena Buretić Tomljanović ◽  
Nada Starčević Čizmarević ◽  
Saša Ostojić ◽  
Pavle Romac ◽  
...  
Keyword(s):  
Case Report ◽  
Nonobstructive Azoospermia ◽  
Autosome Translocation

scholarly journals Hormonal Treatment of Men with Nonobstructive Azoospermia: What Does the Evidence Suggest?

2021 ◽  
Vol 10 (3) ◽  
pp. 387 ◽  
Author(s):  
Ettore Caroppo ◽  
Giovanni M. Colpi
Keyword(s):  
Current Knowledge ◽  
Hormonal Treatment ◽  
Hormonal Control ◽  
Testicular Sperm Extraction ◽  
Nonobstructive Azoospermia ◽  
Sperm Retrieval ◽  
Hormonal Stimulation ◽  
Testosterone Levels ◽  
Retrieval Rate ◽  
Standard Clinical Practice

Hormonal stimulation of spermatogenesis prior to surgery has been tested by some authors to maximize the sperm retrieval yield in patients with nonobstructive azoospermia. Although the rationale of such an approach is theoretically sound, studies have provided conflicting results, and there are unmet questions that need to be addressed. In the present narrative review, we reviewed the current knowledge about the hormonal control of spermatogenesis, the relationship between presurgical serum hormones levels and sperm retrieval rates, and the results of studies investigating the effect of hormonal treatments prior to microdissection testicular sperm extraction. We pooled the available data about sperm retrieval rate in patients with low vs. normal testosterone levels, and found that patients with normal testosterone levels had a significantly higher chance of successful sperm retrieval compared to those with subnormal T levels (OR 1.63, 95% CI 1.08–2.45, p = 0.02). These data suggest that hormonal treatment may be justified in patients with hypogonadism; on the other hand, the available evidence is insufficient to recommend hormonal therapy as standard clinical practice to improve the sperm retrieval rate in patients with nonobstructive azoospermia.

scholarly journals Differential Diagnosis of Azoospermia in Men with Infertility

2021 ◽  
Vol 10 (14) ◽  
pp. 3144
Author(s):  
Danilo L. Andrade ◽  
Marina C. Viana ◽  
Sandro C. Esteves
Keyword(s):  
Differential Diagnosis ◽  
Physical Examination ◽  
Detailed Analysis ◽  
Clinical Management ◽  
Semen Analysis ◽  
Testicular Biopsy ◽  
Nonobstructive Azoospermia ◽  
Sperm Cryopreservation ◽  
Imaging Studies ◽  
Detailed Medical History

The differential diagnosis between obstructive and nonobstructive azoospermia is the first step in the clinical management of azoospermic patients with infertility. It includes a detailed medical history and physical examination, semen analysis, hormonal assessment, genetic tests, and imaging studies. A testicular biopsy is reserved for the cases of doubt, mainly in patients whose history, physical examination, and endocrine analysis are inconclusive. The latter should be combined with sperm extraction for possible sperm cryopreservation. We present a detailed analysis on how to make the azoospermia differential diagnosis and discuss three clinical cases where the differential diagnosis was challenging. A coordinated effort involving reproductive urologists/andrologists, geneticists, pathologists, and embryologists will offer the best diagnostic path for men with azoospermia.

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