Natural History of Cervical Cancer

2013 ◽  
pp. 41-41
Author(s):  
Usha Saraiya
2011 ◽  
Vol 12 (11) ◽  
pp. 986 ◽  
Author(s):  
Karl Ulrich Petry

2018 ◽  
Vol 17 (1) ◽  
pp. 28-33 ◽  
Author(s):  
G. M. Volgareva

Up till now human papillomaviruses (HPV) draw attention of biologists and clinicians owing mostly to the fact that some members of this group cause cervical cancer in women. However it is clear that both women and men take part in HPV distribution throughout population. Data get accumulated on peculiarities of HPV natural history in men when compared with women, as well as on capability of oncogenic HPV to induce cancer in several male organs. The present paper is an attempt to synthesize literature data on specific features of HPV natural history in men. Elucidation of these features is important for working out efficient approaches for prevention of HPV-associated malformation with regard to gender specificities.


1991 ◽  
Vol 27 (11) ◽  
pp. 1411-1416 ◽  
Author(s):  
Steven A. Narod ◽  
D.W. Thompson ◽  
M. Jain ◽  
Claus Wall ◽  
Lois M. Green ◽  
...  

BMJ Open ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. e031103 ◽  
Author(s):  
Surbhi Grover ◽  
Nicola Zetola ◽  
Doreen Ramogola-Masire ◽  
Memory Bvochora-Nsingo ◽  
Allison F Schnader ◽  
...  

IntroductionThe global burden of cancer continues to increase in low- and middle-income countries, particularly in sub-Saharan Africa (SSA). Botswana, a middle-income country in SSA, has the second highest prevalence of HIV worldwide and has seen an increase in human papillomavirus (HPV)-associated cervical cancer over the last decade in the setting of improved survival of HIV-infected women. There is an urgent need to understand more clearly the causes and consequences of HPV-associated cervical cancer in the setting of HIV infection. We initiated the Ipabalele (‘take care of yourself’ in Setswana) programme to address this need for new knowledge and to initiate long-term research programme capacity building in the region. In this manuscript, we describe the components of the programme, including three main research projects as well as a number of essential cores to support the activities of the programme.Methods and proceduresOur multidisciplinary approach aims to further current understanding of the problem by implementing three complementary studies aimed at identifying its molecular, behavioural and clinical determinants. Three participant cohorts were designed to represent the early, intermediate and late stages of the natural history of cervical cancer.The functional structure of the programme is coordinated through programmatic cores. These allow for integration of each of the studies within the cohorts while providing support for pilot studies led by local junior investigators. Each project of the Ipabalele programme includes a built-in capacity building component, promoting the establishment of long-lasting infrastructure for future research activities.Ethics and disseminationInstitutional review board approvals were granted by the University of Pennsylvania, University of Botswana and Ministry of Health and wellness of Botswana. Results will be disseminated via the participating institutions and with the help of the Community Advisory Committee, the project’s Botswana advisory group.


2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Connie D. Cao ◽  
Lena Merjanian ◽  
Joelle Pierre ◽  
Adrian Balica

Background. Human papilloma viruses (HPVs) cause a variety of clinical manifestations in children including skin warts, laryngeal papillomas, and condyloma acuminatum. Whereas the mode of transmission is well understood and management of HPV infection is clearly defined by guidelines in adults, less is known about the mode of transmission, natural history of disease, and appropriate management of high-risk anogenital HPV infections in children. Case. The patient is a previously healthy 6-year-old female who presented with multiple vaginal lesions causing pain and discomfort and was diagnosed with HPV 18 positive CIN I. Summary and Conclusion. Children infected with high-risk HPV subtypes remain a vulnerable patient population, and there is minimal literature on the natural history of disease and effects of overtreatment. Based on a literature review, conservative management, HPV vaccination, and consideration of the cervical cancer screening guidelines for adolescent females are an appropriate treatment course until more studies are reported on cervical cancer screening in survivors of child sexual abuse.


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