The clinical utility of objective tests (biomarkers)

2013 ◽  
pp. 41-41
Author(s):  
Michael Lemp
Keyword(s):  
Clinical Utility ◽  
Objective Tests

scholarly journals Stress Oximetry: Description of a Test to Determine Readiness for Discontinuing Oxygen Therapy in Infants with Chronic Lung Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Naveed Hussain ◽  
Janet Schwenn ◽  
Jennifer Trzaski ◽  
Mariann Pappagallo
Keyword(s):  
Positive Predictive Value ◽  
Clinical Utility ◽  
Oxygen Therapy ◽  
Inhalation Therapy ◽  
Oxygen Inhalation Therapy ◽  
Inclusion Criteria ◽  
Clinical Protocol ◽  
Oxygen Inhalation ◽  
Successful Weaning ◽  
Objective Tests

Background. In infants with CLD there are no objective tests to monitor an infant’s progress towards weaning out of oxygen inhalation therapy (O2IT). A test involving staged maneuvers of increasing respiratory stress while decreasing oxygen support, termed Stress Oximetry (StressOx), has been used at our center for weaning O2IT.Objective. To report the clinical utility of “StressOx” in evaluating readiness for discontinuing O2IT in infants with CLD.Methods. A retrospective review was done of StressOx tests administered at our center from 2002-2008. StressOx was performed based on a consistent clinical protocol in all eligible infants on O2IT. O2IT was generally discontinued after infant had passed two StressOx tests and subsequently infants were monitored for a minimum of 7 days to determine successful weaning.Results. There were 279 infants with 899 tests that met inclusion criteria. An average of 3 tests per infant was done, one week apart. The test had a specificity of 97.4% and a positive predictive value of 99.6% in determining success of discontinuing O2IT.Conclusions. StressOx appears to be a clinically useful test that may help in determining an infant’s ability to successfully wean out of O2IT. Further validation of this test is warranted.

Evaluation of a Soluble Fibrin Assay in Patients with Suspected Deep Vein Thrombosis

1995 ◽  
Vol 74 (03) ◽  
pp. 833-836 ◽  
Author(s):  
Jeffrey S Ginsberg ◽  
Sergio Siragusa ◽  
James Douketis ◽  
Marilyn Johnston ◽  
Karen Moffat ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Clinical Utility ◽  
Predictive Values ◽  
Soluble Fibrin ◽  
Vein Thrombosis ◽  
Potential Clinical Utility ◽  
Objective Tests ◽  
Deep Vein

SummaryBackground. The objective of this study was to determine the clinical utility of an enzyme immunoassay (HIA) for soluble fibrin in patients with clinically suspected deep vein thrombosis (DVT).Methods and Results. 101 unselected patients with clinically suspected DVT underwent blood sampling for measurement of plasma levels of soluble fibrin, and objective testing for DVT. According to results of the objective tests, patients were classified as DVT-positive (n = 34) or DVT-negative (n = 67). Using different cut-points of soluble fibrin results, the sensitivities, specificities, positive and negative predictive values of the soluble fibrin assay were calculated. A soluble fibrin result of ≤0.75 mg/ml showed a sensitivity and negative predictive value of 100%, and a specificity of 17.9% for DVT, a soluble fibrin result of ≤ 1.40 mg/ml showed a sensitivity of 91.2% and a negative predictive value of 93.6%, and a specificity of 65.7% for DVT, whereas a soluble fibrin result of ≤ 8.0 mg/ml showed a specificity and positive predicive value of 100% for DVT.Conclusions. This study demonstrates that the soluble fibrin assay used in the study has potential clinical utility as a diagnostic test in patients with clinically suspected DVT and supports further evaluation of this assay.

Clinical Utility of Objective Tests for Dry Eye Disease

Cornea ◽  
2012 ◽  
Vol 31 (9) ◽  
pp. 1000-1008 ◽  
Author(s):  
Benjamin D. Sullivan ◽  
Leslie A. Crews ◽  
Barş Sönmez ◽  
Maria F. de la Paz ◽  
Ebru Comert ◽  
...  
Keyword(s):  
Dry Eye ◽  
Clinical Utility ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Objective Tests

The clinical utility of subjective vs. objective tests of excessive daytime sleepiness in the assessment of patients with sleep apnea

2017 ◽  
Vol 40 ◽  
pp. e192-e193
Author(s):  
Y. Li ◽  
A. Vgontzas ◽  
I. Kritikou ◽  
J. Fernandez-Mendoza ◽  
M. Basta ◽  
...  
Keyword(s):  
Sleep Apnea ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Clinical Utility ◽  
Objective Tests

scholarly journals 0437 THE CLINICAL UTILITY OF SUBJECTIVE VS. OBJECTIVE TESTS OF EXCESSIVE DAYTIME SLEEPINESS IN THE ASSESSMENT OF PATIENTS WITH SLEEP APNEA

SLEEP ◽  
2017 ◽  
Vol 40 (suppl_1) ◽  
pp. A162-A163
Author(s):  
Y Li ◽  
AN Vgontzas ◽  
I Kritikou ◽  
J Fernandez-Mendoza ◽  
M Basta ◽  
...  
Keyword(s):  
Sleep Apnea ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Clinical Utility ◽  
Objective Tests

Type V Bekesy Pattern: Interpretation and Clinical Utility

1967 ◽  
Vol 10 (4) ◽  
pp. 733-744 ◽  
Author(s):  
William F. Rintelmann ◽  
Earl R. Harford
Keyword(s):  
Clinical Utility ◽  
The Past ◽  
Type V ◽  
Clinical Cases

Recent studies indicate there is some disagreement concerning the interpretation and clinical utility of the Type V Bekesy pattern. Bekesy tracings obtained over the past six years from a sample of clinical cases were analyzed and a definition was established for the Type V pattern. This definition was applied to Bekesy tracings obtained from normal listeners, hypoacusics, and pseudohypoacusics. The Type V pattern was found frequently among pseudohypoacusics and only rarely among other individuals.

“I Can See What You’re Saying”: Clinical Utility of Spectral Moment Analysis

2011 ◽  
Vol 21 (2) ◽  
pp. 44-54
Author(s):  
Kerry Callahan Mandulak
Keyword(s):  
Speech Production ◽  
Speech Signal ◽  
Clinical Utility ◽  
Acoustic Analysis ◽  
Moment Analysis ◽  
Analysis Tool ◽  
Spectral Moment ◽  
Clinical Measure ◽  
Perceptual Analysis ◽  
Disordered Speech

Spectral moment analysis (SMA) is an acoustic analysis tool that shows promise for enhancing our understanding of normal and disordered speech production. It can augment auditory-perceptual analysis used to investigate differences across speakers and groups and can provide unique information regarding specific aspects of the speech signal. The purpose of this paper is to illustrate the utility of SMA as a clinical measure for both clinical speech production assessment and research applications documenting speech outcome measurements. Although acoustic analysis has become more readily available and accessible, clinicians need training with, and exposure to, acoustic analysis methods in order to integrate them into traditional methods used to assess speech production.

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