History of In Vitro Fertilization

Although in vitro fertilization (IVF) is used widely for a variety of purposes, it is often not appreciated how this technology was developed. A large number of experiments beginning in 1878 contributed to the first successful reports of IVF over 75 years later. The discovery of sperm capacitation in 1951 was central to the development of IVF technology, and it was rapidly followed by the first convincing reports of IVF in several species. The ability to fertilize oocytes in vitro has allowed major advances to be made into understanding the mechanisms involved in fertilization and early development, and IVF now supports reproductive biotechnology in animals and in humans. This article is a historical review of key experiments that helped to provide the basis for present day IVF procedures, placed into context with current practice.

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A history of elevated basal Follicle Stimulating Hormone (FSH) elevations is predictive of in vitro fertilization (IVF) outcome

Fertility and Sterility ◽

10.1016/s0015-0282(03)01327-x ◽

2003 ◽

Vol 80 ◽

pp. 162

Author(s):

Jeffrey E. Roberts ◽

Steven D. Spandorfer ◽

Sozos J. Fasouliotis ◽

Zev Rosenwaks

Keyword(s):

In Vitro Fertilization ◽

Follicle Stimulating Hormone ◽

Ivf Outcome ◽

Vitro Fertilization ◽

History Of ◽

Stimulating Hormone

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Editorial — History of in vitro fertilization and related techniques in Iran: The view of professor Safaa Al-Hasani

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v19i1.8383 ◽

2021 ◽

Author(s):

Abbas Aflatoonian

Keyword(s):

In Vitro Fertilization ◽

Vitro Fertilization ◽

History Of

This is an Editorial and does not have an abstract. Please download the PDF or view the HTML.

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Case Report on Primary Infertility with Hypothyroidism and Diabetes Mellitus

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i58b34202 ◽

2021 ◽

pp. 263-266

Author(s):

Thool Bali ◽

Lokhande Shalini ◽

A. Lalawmpuii ◽

Ambule Kalyani ◽

Shendre Vaishnavi ◽

...

Keyword(s):

Diabetes Mellitus ◽

In Vitro Fertilization ◽

Sperm Count ◽

Vitro Fertilization ◽

Primary Infertility ◽

History Of ◽

Irregular Menses ◽

One Year ◽

Loss Of Appetite

Introduction: Infertility is the inability, by natural means, of an animal to reproduce. Typically, adult species are not in their normal state of health. A woman who is unable to conceive well will define infertility as unable to bear a full-term pregnancy. Because of any ejaculating disease, and any declining sperm count, men are directly liable for 30-40% infertility. The WHO estimates the overall prevalence of primary infertility in India at 3.9% and 16.8%. Fertility estimates differ widely between India and 3.7% in Utter Pradesh and Maharashtra. Case Presentation: On 9/12/2020, a 38-year-old female came for In Vitro Fertilization with a known case of primary infertility in AVBR Hospital, Wardha. Her complaint was inability to conceive for 4 years, irregular menses, headache, sleep disturbance, loss of appetite. She was admitted for in-vitro fertilization therapy for the 2nd cycle. She had a history of hypothyroidism for 8 years for which she has been taking Thyrox 50mg OD tablet and has Diabetes Mellitus for one year since she is taking Metformin 500mg BD tablet. Instead, she has no concerns about asthma, tuberculosis, epilepsy, etc. On 9/12/2020, she underwent an embryo transfer. Diagnostic Evaluation: The diagnostic hysteroscopy was conducted at the private hospital in Amravati 2 years ago. She has been diagnosed with nullipara for 4 years as a primary infertility. She has already undergone 2 cycles of Intra Uterine Insemination (IUI) and 1 cycle of in vitro fertilization. Hysterosalpingography: Both fallopian tubes are normal & patent uterus is normal. Conclusion: There is multifactorial infertility. In both men and women, anatomy, physiology, the environment, hormones and genetics all play a role in causing infertility. Therefore, in the coming years, it is a very important problem and research in this zone is very essential.

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503. SUCCESSFUL IN VITRO FERTILIZATION (IVF) AFTER PRIOR FAILED IVF UTILIZING A PROPRIETARY BLEND OF SUPPLEMENTS

Reproduction Fertility and Development ◽

10.1071/srb09abs503 ◽

2009 ◽

Vol 21 (9) ◽

pp. 104

Author(s):

B. Poursharif ◽

J. Paden ◽

B. Acacio

Keyword(s):

In Vitro Fertilization ◽

Egg Quality ◽

Clinical Pregnancy ◽

Ivf Outcome ◽

Positive Role ◽

Vitro Fertilization ◽

Embryo Fragmentation ◽

History Of

Background: To date, little is known about the effect of supplements on the outcome of in vitro fertilization (IVF). The data on this matter is limited to measuring the overall pregnancy rate on a population of women who took a specific supplement, and not on IVF patients. Objectives: To demonstrate the positive role of an investigated supplement in the outcome of patients undergoing IVF. Method: 18 women undergoing IVF treatment were placed on a proprietary combination of vitamins and antioxidants designed to encourage blood flow and improve egg quality. The women were selected for this protocol mostly due to prior poor egg quality and/or large amount of embryo fragmentation .The women took supplementation twice daily for 4–12 weeks prior to transfer. The charts of the patients who used the supplements were used to obtain data. Previous failed IVF was defined as negative pregnancy. Successful IVF outcome was determined by positive chemical pregnancy and clinical pregnancy after one attempt. Range and mean was calculated for patient's age and number of failed previous IVF attempts. The previous IVF attempts were performed in different centers without using this supplement in all patients. Results: Eighteen patients used the supplement before and during their IVF cycles. Patient's age ranged from 28 to 44 with mean of 36.4 years. They had on average, 2 prior failed IVF attempts. Seventeen of 18 patients had successful IVF outcome. The failed patient required frozen testicular extraction of sperm (TESE), prior to IVF. Summary: Seventeen of 18 patients who used our supplements had successful IVF. These patients failed an average of 2 previous IVF attempts without using our supplements. Conclusion: Usage of our supplements is associated with improved rates of success in patients undergoing IVF with a history of prior failed IVF attempts. Larger studies need to be conducted.

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