DNA-Templated Organic Synthesis (DTS): A Novel Approach to the Discovery of Functional Small Molecules Based on Nature's Evolutionary Principles

: In recent years, photocatalytic technology has shown great potential as a low-cost, environmentally friendly, and sustainable technology. Compared to other light sources in photochemical reaction, LEDs have advantages in terms of efficiency, power, compatibility, and environmentally-friendly nature. This review highlights the most recent advances in LED-induced photochemical reactions. The effect of white and blue LEDs in reactions such as oxidation, reduction, cycloaddition, isomerization, and sensitization is discussed in detail. No other reviews have been published on the importance of white and blue LED sources in the photocatalysis of organic compounds. Considering all the facts, this review is highly significant and timely.

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ChemInform Abstract: Alkoxy Radicals in Organic Synthesis. A Novel Approach to a Key Intermediate in Milbemycin Chemistry.

ChemInform ◽

10.1002/chin.199447272 ◽

2010 ◽

Vol 25 (47) ◽

pp. no-no

Author(s):

N. HUSSAIN ◽

D. O. MORGAN ◽

C. R. WHITE ◽

J. A. MURPHY

Keyword(s):

Organic Synthesis ◽

Alkoxy Radicals ◽

Novel Approach

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Transformations of Monoterpenes with the p-Menthane Skeleton in the Enzymatic System of Bacteria, Fungi and Insects

Molecules ◽

10.3390/molecules25204840 ◽

2020 ◽

Vol 25 (20) ◽

pp. 4840

Author(s):

Małgorzata Grabarczyk ◽

Wanda Mączka ◽

Anna K. Żołnierczyk ◽

Katarzyna Wińska

Keyword(s):

Small Molecules ◽

Organic Synthesis ◽

Optical Purity ◽

Biological Properties ◽

Enzymatic Reactions ◽

Enzymatic System ◽

Chemical Waste ◽

Standard Methods ◽

High Optical Purity ◽

The Cost

The main objective of this article was to present the possibilities of using the enzymatic system of microorganisms and insects to transform small molecules, such as monoterpenes. The most important advantage of this type of reaction is the possibility of obtaining derivatives that are not possible to obtain with standard methods of organic synthesis or are very expensive to obtain. The interest of industrial centers focuses mainly on obtaining particles of high optical purity, which have the desired biological properties. The cost of obtaining such a compound and the elimination of toxic or undesirable chemical waste is important. Enzymatic reactions based on enzymes alone or whole microorganisms enable obtaining products with a specific structure and purity in accordance with the rules of Green Chemistry.

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Lemon Juice: A versatile reusable biocatalyst for the synthesis of bioactive organic compounds as well as numerous nanoparticles based catalytic system

Current Organic Chemistry ◽

10.2174/1385272825666210317151732 ◽

2021 ◽

Vol 25 ◽

Author(s):

Yogesh Brijwashi Sharma ◽

Bhakti Umesh Hirlekar ◽

Yogesh P. Bharitkar ◽

Abhijit Hazra

Keyword(s):

Green Chemistry ◽

Small Molecules ◽

Organic Synthesis ◽

Potential Role ◽

Fruit Juice ◽

Lemon Juice ◽

Review Article ◽

Organic Transformations ◽

Environment Friendly ◽

Principal Role

Green chemistry is an essential part of the chemistry for the organic synthesis and also plays a principal role to save the environment from the harmful and toxic catalysts. Fruit juice catalyzed chemistry is a vital part of green chemistry in which lemon juice play a potential role in a various organic transformations. This review article has been summarized (from 2011-2020) with the application and importance of lemon juice in synthetic organic transformation as well as synthesis of various type of nanoparticles and catalysts. This review article can help the researcher to develop the route for the synthesis of various scaffolds, small molecules, nanoparticles and catalysts under economical and environment friendly condition.

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Structural studies on 14-3-3ζ: Compounds that target the dimer interface

Acta Crystallographica Section A Foundations and Advances ◽

10.1107/s2053273314091918 ◽

2014 ◽

Vol 70 (a1) ◽

pp. C808-C808

Author(s):

Urmi Dhagat ◽

Joanna Woodcock ◽

Chrystal Tiong ◽

Jessica Holien ◽

Carl Coolen ◽

...

Keyword(s):

Small Molecules ◽

Disease Recurrence ◽

Therapeutic Benefit ◽

Leukemic Cells ◽

Structural Studies ◽

Salt Bridges ◽

Dimer Interface ◽

Novel Approach ◽

Apoptotic Activity

14-3-3 proteins are a highly conserved family of dimeric phospho-serine binding proteins that modulate the functions of key cellular proteins involved in signaling. 14-3-3ζ plays a prominent role in signaling pathways leading to inhibition of apoptosis, sequestration of tumor suppressor proteins and activation of signalling pathways that promote growth. 14-3-3ζ expression is up-regulated in many human cancers and associated with enhanced survival of cancer cells. The significant association of 14-3-3ζ over expression with disease recurrence and chemo-resistance makes this protein an attractive candidate for anti-cancer therapy. The anti-apoptotic activity of 14-3-3ζ is entirely dependent on the dimeric state of the protein. Our studies have shown that 14-3-3ζ activity is regulated by sphingosine and other lipid analogs that render 14-3-3 phosphorylatable, disrupting its dimeric state thereby leading to apoptosis [1]. Structural studies and mutagenesis on 14-3-3ζ confirm that the dimeric state of 14-3-3ζ is stabilized by salt bridges that form across the dimer interface. Based on this we have carried out an in silico screen of a virtual library of drug-like small molecules to identify compounds that bind to the dimer interface of 14-3-3ζ. Candidate small molecules have been assessed for their ability to render 14-3-3ζ phosphorylatable in vitro and consequently we have identified a family of small molecules with 14-3-3ζ dimer-destabilizing properties. These small molecules induce apoptosis in leukemic cells by activating apoptotic mediators known to be regulated by dimeric 14-3-3. We have recently solved the crystal structure of 14-3-3ζ with one of our hit compounds bound at the dimer interface. Our results suggest that relatively small perturbations at the dimer interface, can destabilize the salt bridges that hold 14-3-3 dimers together, thus providing a novel approach to targeting 14-3-3 proteins for therapeutic benefit.

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