scholarly journals Primary skin manifestation of non-small-cell lung cancer – a case study

2019 ◽  
Vol 36 (3) ◽  
pp. 369-370
Author(s):  
Anna Grzywa-Celińska ◽  
Katarzyna Szmygin-Milanowska ◽  
Justyna Emeryk-Maksymiuk ◽  
Rafał Celiński ◽  
Grzegorz Sobieszek ◽  
...  
Lung Cancer ◽  
2016 ◽  
Vol 92 ◽  
pp. 1-7 ◽  
Author(s):  
Kinga Malottki ◽  
Sanjay Popat ◽  
Jonathan J. Deeks ◽  
Richard D. Riley ◽  
Andrew G. Nicholson ◽  
...  

2016 ◽  
Vol 9 (1) ◽  
pp. 171-176 ◽  
Author(s):  
Corey A. Carter ◽  
Bryan T. Oronsky ◽  
Scott Z. Caroen ◽  
Jan J. Scicinski ◽  
Aiste Degesys ◽  
...  

RRx-001 is a pan-active, systemically nontoxic epigenetic inhibitor under investigation in advanced non-small cell lung cancer, small-cell lung cancer and high-grade neuroendocrine tumors in a Phase II clinical trial entitled TRIPLE THREAT (NCT02489903), which reexposes patients to previously effective but refractory platinum doublets after treatment with RRx-001. The purpose of this case study is first to report a partial response to carboplatin and etoposide in a patient with small-cell lung cancer pretreated with RRx-001, indicating episensitization or resensitization by epigenetic mechanisms, and second to discuss the literature related to small-cell lung cancer and episensitization.


2015 ◽  
Vol 18 (7) ◽  
pp. A825
Author(s):  
G Lopes ◽  
O Arrieta ◽  
P Bonelli ◽  
R Castano ◽  
S Sehdev ◽  
...  

2016 ◽  
Vol 27 (6) ◽  
pp. 1155-1160 ◽  
Author(s):  
C.J. Morrow ◽  
F. Trapani ◽  
R.L. Metcalf ◽  
G. Bertolini ◽  
C.L. Hodgkinson ◽  
...  

2021 ◽  
Vol 23 (1) ◽  
pp. 112-115
Author(s):  
Konstantin V. Menshikov ◽  
Aleksandr V. Sultanbaev ◽  
Shamil I. Musin ◽  
Irina A. Menshikova ◽  
Ainur F. Nasretdinov ◽  
...  

Lung cancer is one of the most common tumors in humans. The incidence is in one of the leading positions. In 2019 1327 patients with this pathology were identified in the Republic of Bashkortostan. Of these, with stage III of the disease 28.7%, with stage IV 45.8%, which is higher. Small cell lung cancer (SCLC) is one of the most prognostically unfavorable malignant tumors in humans. About 15% of lung tumors are SCLC. The first combination for the treatment of advanced SCLC after etoposide and platinum preparations was the combination of the etoposide + carboplatin (EP) regimen with atezolizumab. In the IMpower133 study, after a median follow-up of 13.9 months. median overall survival in the atezolizumab group was 12.3 months, and in the placebo group 10.3 months. In clinical observation, the effectiveness of the combination of the EP regimen with atezolizumab has been demonstrated. A patient with SCLC received 4 courses of EP therapy with atezolizumab and 14 injections of atezolizumab. The partial response achieved is retained. Case study efficacy and satisfactory safety profile of the combination of atezolizumab and the EP regimen.


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