Serum concentrations of antimicrobial peptide cathelicidin LL-37 in patients with bacterial lung infections

Abstract. Thyroid hormones play an important role in body homeostasis by facilitating metabolism of lipids and glucose, regulating metabolic adaptations, responding to changes in energy intake, and controlling thermogenesis. Proper metabolism and action of these hormones requires the participation of various nutrients. Among them is zinc, whose interaction with thyroid hormones is complex. It is known to regulate both the synthesis and mechanism of action of these hormones. In the present review, we aim to shed light on the regulatory effects of zinc on thyroid hormones. Scientific evidence shows that zinc plays a key role in the metabolism of thyroid hormones, specifically by regulating deiodinases enzymes activity, thyrotropin releasing hormone (TRH) and thyroid stimulating hormone (TSH) synthesis, as well as by modulating the structures of essential transcription factors involved in the synthesis of thyroid hormones. Serum concentrations of zinc also appear to influence the levels of serum T3, T4 and TSH. In addition, studies have shown that Zinc transporters (ZnTs) are present in the hypothalamus, pituitary and thyroid, but their functions remain unknown. Therefore, it is important to further investigate the roles of zinc in regulation of thyroid hormones metabolism, and their importance in the treatment of several diseases associated with thyroid gland dysfunction.

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Variability of Total Phenytoin Serum Concentrations Within Elderly Nursing Home Residents

Yearbook of Neurology and Neurosurgery ◽

10.1016/s0513-5117(08)70268-0 ◽

2006 ◽

Vol 2006 ◽

pp. 54-55

Author(s):

A. Verma

Keyword(s):

Nursing Home ◽

Nursing Home Residents ◽

Serum Concentrations

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How much citalopram is equivalent to 50 ng/ml sertraline? Standardization of serum concentrations of six different SSRIs by measuring serotonin transporter occupancy

Pharmacopsychiatry ◽

10.1055/s-0031-1292468 ◽

2011 ◽

Vol 44 (06) ◽

Author(s):

N Dreimüller ◽

A Tadic ◽

G Gründer ◽

C Hiemke

Keyword(s):

Serotonin Transporter ◽

Serum Concentrations

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Do Extra-Platelet Sources Contribute to the Plasma Level of Thrombospondin?

Thrombosis and Haemostasis ◽

10.1055/s-0038-1642769 ◽

1988 ◽

Vol 59 (02) ◽

pp. 273-276 ◽

Cited By ~ 8

Author(s):

J Dawes ◽

D A Pratt ◽

M S Dewar ◽

F E Preston

Keyword(s):

Platelet Count ◽

Background Concentration ◽

Serum Concentrations ◽

Bone Marrow Depression ◽

Serial Sampling ◽

Control Serum ◽

Platelet Release ◽

Highly Correlated ◽

The Relationship

SummaryThrombospondin, a trimeric glycoprotein contained in the platelet α-granules, has been proposed as a marker of in vivo platelet activation. However, it is also synthesised by a range of other cells. The extraplatelet contribution to plasma levels of thrombospondin was therefore estimated by investigating the relationship between plasma thrombospondin levels and platelet count in samples from profoundly thrombocytopenic patients with marrow hypoplasia, using the platelet-specific α-granule protein β-thromboglobulin as control. Serum concentrations of both proteins were highly correlated with platelet count, but while plasma β-thromboglobulin levels and platelet count also correlated, there was no relationship between the number of platelets and thrombospondin concentrations in plasma. Serial sampling of patients recovering from bone marrow depression indicated that the plasma thrombospondin contributed by platelets is superimposed on a background concentration of at least 50 ng/ml probably derived from a non-platelet source, and plasma thrombospondin levels do not simply reflect platelet release.

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