scholarly journals Rapid onset of systemic lupus erythematosus with rarely observed cutaneous lesions

2019 ◽  
Vol 106 (3) ◽  
pp. 291-301
Author(s):  
Martyna Skręta-Śliwińska ◽  
Anna Woźniacka ◽  
Ilona Kurnatowska ◽  
Maciej Goździk ◽  
Agnieszka Żebrowska
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Rapid Onset ◽  
Systemic Lupus ◽  
Cutaneous Lesions

Facial Lipoatrophy following Systemic Lupus Erythematosus

2003 ◽  
Vol 7 (3) ◽  
pp. 232-235
Author(s):  
Audrey Dupéré ◽  
Yves Poulin
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Subcutaneous Fat ◽  
Systemic Lupus ◽  
Rapid Loss ◽  
Cutaneous Lesions ◽  
Partial Lipodystrophy ◽  
C3 Nephritic Factor ◽  
Facial Lipoatrophy ◽  
Immunological Factors

Background: Acquired partial lipodystrophy is a rare disorder. An association with systemic lupus erythematosus has been reported. In these cases, an immunologic basis is suggested by the presence of C3 nephritic factor and hypocomplementemia. Objective: The following report presents the case of a woman who developed a rapid loss of facial subcutaneous fat a few months after complete spontaneous resolution of cutaneous lesions of lupus. Conclusion: Absence of C3NeF in this case suggests that other immunological factors may be involved in the pathogenesis.

scholarly journals A Unique Case of Systemic Lupus Erythematosus Pelvic Vasculitis

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Pamela Traisak ◽  
Shristi Basnyat ◽  
Hala Eid ◽  
Patrick Cronin ◽  
Halyna Kuzyshyn ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Vasculitis ◽  
Case Reports ◽  
Female Genital Tract ◽  
Pelvic Mass ◽  
Systemic Lupus ◽  
Cutaneous Lesions ◽  
Unique Case ◽  
Life Threatening

The clinical presentation of Systemic Lupus Erythematosus (SLE) is diverse and vasculitis can be a potential manifestation. Cutaneous lesions involving small vessels are the most frequent presentation. However, medium and large vessel vasculitis may present with life-threatening visceral manifestations. We present a unique case of pelvic vasculitis mimicking a pelvic mass as an initial presentation of SLE. There are case reports of systemic vasculitis involving the female genital tract with giant cell arteritis (GCA), polyarteritis nodosa (PAN), and granulomatous with polyangiitis and microscopic polyangiitis (GPA/MPA), among others, but only a few cases attributed to SLE. Awareness of this condition and a prompt diagnosis are warranted as this is a severe and potentially life-threatening condition.

Systemic Lupus Erythematosus

1999 ◽  
Vol 12 (4) ◽  
pp. 335-345
Author(s):  
Steven A. Scott
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Severe Disease ◽  
Clinical Manifestations ◽  
Multiple Organ ◽  
High Dose ◽  
Inflammatory Disorder ◽  
Systemic Lupus ◽  
Cutaneous Lesions ◽  
Immune System Dysfunction

Systemic lupus erythematosus (SLE) is a chronic, multiple-organ system inflammatory disorder associated with immune system dysfunction. Autoantibodies are produced that react with self-antigens in cell membranes and nuclear and cytoplasmic constituents to produce tissue damage. Commonly observed clinical manifestations include arthritis, myalgia, fever, cutaneous lesions, cytopenia, and renal, CNS, and cardiopulmonary involvement. Minor manifestations can be managed with relatively nontoxic agents such as nonsteroidal anti-inflammatory drugs, topical corticosteroids, and antimalarials. Severe disease involving the kidneys, CNS, and cardiopulmonary systems requires the aggressive use of more toxic agents such as high-dose corticosteroids, azathioprine, and cyclophosphamide. Other supportive and ancillary therapies are also required to manage the complications frequently associated with SLE.

scholarly journals Crusted scabies in a chid with systemic lupus erythematosus

1992 ◽  
Vol 25 (1) ◽  
pp. 73-75 ◽  
Author(s):  
Nurimar C.F. Wanke ◽  
Claudia Melo ◽  
Viviam Balassiano
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Renal Failure ◽  
Lupus Erythematosus ◽  
Marked Improvement ◽  
Sarcoptes Scabiei ◽  
Systemic Lupus ◽  
Cutaneous Lesions ◽  
Crusted Scabies

A child with systemic lupus erythematosus who has been treated with prednisone for three years, developed crusted scabies. Scrapings from lesions revealed Sarcoptes scabiei adult mites mad eggs. The patient died with septicemia and renal failure soon after starting topical 20% sulfur. A marked improvement was observed in the cutaneous lesions.

scholarly journals New findings associated with presumptive systemic lupus erythematosus in a kitten

2020 ◽  
Vol 6 (2) ◽  
pp. 205511692097927
Author(s):  
Romain Huvé ◽  
Pascal Fontaine ◽  
Marie-Claude Blais ◽  
Bérénice Conversy
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Clinical Activity ◽  
Systemic Lupus ◽  
Cutaneous Lesions ◽  
Presumptive Diagnosis ◽  
Specific Test ◽  
Oral Ulcers ◽  
New Findings ◽  
Diagnostic Work

Case summary An 8-month-old neutered male domestic shorthair kitten was examined for anorexia, lethargy and palatine ulcers. Systemic lupus erythematosus (SLE) was suspected based on a positive antinuclear antibody (ANA) titer and six manifestations of autoimmunity: fever, paronychia, oral ulcers, proteinuria, thrombocytopenia and leukopenia. Mastocytemia was observed on the blood smear. Although the clinical presentation of this case meets the classification criteria for SLE in humans, tick-borne disease and histopathology evaluation of the oral and cutaneous lesions would have been necessary to support a definite diagnosis of SLE. Baseline ANA titration was performed in two laboratories with conflicting results, which may reflect substrate differences used for the titration, but a false-positive result cannot be excluded. The cat received prednisolone and all clinical and laboratory abnormalities resolved after two months of treatment. Subsequent ANA titers remained positive and were not correlated to the patient’s clinical progression. Relevance and novel information This report describes new findings associated with a presumptive diagnosis of SLE in a kitten, highlighting that SLE may not be ruled out even in young cats and may be associated with mastocytemia. ANA titration is part of the initial diagnostic work-up of SLE but is a non-specific test and discrepancies can be observed between laboratories. The titration of more specific antibodies such as those used in humans would be helpful to diagnose SLE. ANA titration may not correlate with clinical activity of SLE; hence, the interest of an ANA titer follow-up to establish disease control warrants further investigation.

scholarly journals Utilization of Rituximab for Refractory Rowell Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Sukhraj Singh ◽  
Sandra Sheffield ◽  
Nisha Chowdhury ◽  
Swetha Nuthulaganti ◽  
Zareen Vaghaiwalla ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Erythema Multiforme ◽  
Lupus Erythematosus ◽  
Cell Activation ◽  
Standard Of Care ◽  
Mast Cell Activation ◽  
Erythematous Rash ◽  
Systemic Lupus ◽  
Cutaneous Lesions ◽  
Excellent Response

Rowell syndrome describes the occurrence of erythema multiforme-like lesions in patients with cutaneous lesions of lupus erythematosus. The clinical picture of atypical erythema multiforme-like lesions, presence of chilblains, speckled ANA pattern, anti-Ro/SSA, or anti-La/SSB antibodies, and absence of infectious or pharmacologic triggers in a patient with systemic lupus erythematosus are some of the classic clinical and serologic features. Histopathologic and serologic findings can help differentiate this process from erythema multiforme. We present a case of young woman with systemic lupus erythematosus, end-stage renal disease due to lupus nephritis, and a remote history of Steven–Johnson syndrome due to sulfa allergy who presented to the hospital with a recurrent, progressive, targetoid erythematous rash involving more than 60% of her body surface area. Our patient had several hospitalizations in the recent past for this erythematous rash and had failed oral therapy with prednisone 1 mg/kg and hydroxychloroquine. In view of the minimal improvement and increasing severity and patient exhibiting early features of mast cell activation syndrome, the patient was treated with pulse intravenous glucocorticoids followed by rituximab with an excellent response. We highlight a unique case report of progressive Rowell syndrome refractory to standard of care with an excellent response to rituximab.

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