scholarly journals OP0280 THE SELECTIVE JAK1 INHIBITOR INCB054707 AMELIORATES CUTANEOUS LESIONS IN A SPONTANEOUS MURINE MODEL OF SYSTEMIC LUPUS ERYTHEMATOSUS

2019 ◽  
Author(s):  
Brittany Fay ◽  
Xin He ◽  
Alexander Margulis ◽  
Yan-Ou Yang ◽  
Yu LI ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Murine Model ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Cutaneous Lesions

Facial Lipoatrophy following Systemic Lupus Erythematosus

2003 ◽  
Vol 7 (3) ◽  
pp. 232-235
Author(s):  
Audrey Dupéré ◽  
Yves Poulin
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Subcutaneous Fat ◽  
Systemic Lupus ◽  
Rapid Loss ◽  
Cutaneous Lesions ◽  
Partial Lipodystrophy ◽  
C3 Nephritic Factor ◽  
Facial Lipoatrophy ◽  
Immunological Factors

Background: Acquired partial lipodystrophy is a rare disorder. An association with systemic lupus erythematosus has been reported. In these cases, an immunologic basis is suggested by the presence of C3 nephritic factor and hypocomplementemia. Objective: The following report presents the case of a woman who developed a rapid loss of facial subcutaneous fat a few months after complete spontaneous resolution of cutaneous lesions of lupus. Conclusion: Absence of C3NeF in this case suggests that other immunological factors may be involved in the pathogenesis.

The effect of OM-89 (SUBREUM®) on the murine model of systemic lupus erythematosus MRL-lpr/lpr

Lupus ◽  
1997 ◽  
Vol 6 (5) ◽  
pp. 436-440 ◽  
Author(s):  
YY Dhaher ◽  
MA Khamashta ◽  
B. Hartley ◽  
N. Taub ◽  
JC Farine ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Murine Model ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Suppression of autoreactive T and B lymphocytes by anti‐annexin A1 antibody in a humanized NSG murine model of systemic lupus erythematosus

2019 ◽  
Vol 199 (3) ◽  
pp. 278-293 ◽  
Author(s):  
N. Mihaylova ◽  
P. Chipinski ◽  
S. Bradyanova ◽  
T. Velikova ◽  
E. Ivanova‐Todorova ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
B Lymphocytes ◽  
Murine Model ◽  
Lupus Erythematosus ◽  
T And B Lymphocytes ◽  
Annexin A1 ◽  
Systemic Lupus

scholarly journals A Unique Case of Systemic Lupus Erythematosus Pelvic Vasculitis

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Pamela Traisak ◽  
Shristi Basnyat ◽  
Hala Eid ◽  
Patrick Cronin ◽  
Halyna Kuzyshyn ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Vasculitis ◽  
Case Reports ◽  
Female Genital Tract ◽  
Pelvic Mass ◽  
Systemic Lupus ◽  
Cutaneous Lesions ◽  
Unique Case ◽  
Life Threatening

The clinical presentation of Systemic Lupus Erythematosus (SLE) is diverse and vasculitis can be a potential manifestation. Cutaneous lesions involving small vessels are the most frequent presentation. However, medium and large vessel vasculitis may present with life-threatening visceral manifestations. We present a unique case of pelvic vasculitis mimicking a pelvic mass as an initial presentation of SLE. There are case reports of systemic vasculitis involving the female genital tract with giant cell arteritis (GCA), polyarteritis nodosa (PAN), and granulomatous with polyangiitis and microscopic polyangiitis (GPA/MPA), among others, but only a few cases attributed to SLE. Awareness of this condition and a prompt diagnosis are warranted as this is a severe and potentially life-threatening condition.

scholarly journals VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus

Immunology ◽  
2014 ◽  
Vol 142 (4) ◽  
pp. 594-602 ◽  
Author(s):  
Paolo Fagone ◽  
Karuppiah Muthumani ◽  
Katia Mangano ◽  
Gaetano Magro ◽  
Pier Luigi Meroni ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Murine Model ◽  
Lupus Erythematosus ◽  
Toll Like Receptor ◽  
Systemic Lupus ◽  
Toll Like Receptor 4
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