scholarly journals CYSTITIS CYSTICA – CHRONIC URINARY BLADDER INFLAMMATION IN CHILDREN

2021 ◽  
Vol 15 (1) ◽  
pp. 61-67
Author(s):  
Magdalena Szymanek-Szwed ◽  
Beata Jurkiewicz ◽  
Joanna Samotyjek ◽  
Katarzyna Załęska-Oracka
Keyword(s):  
Urinary Bladder ◽  
Bladder Inflammation ◽  
Cystitis Cystica

Polyps and Masses of the Pediatric Urinary Bladder: A 21-Year Pathology Review

2011 ◽  
Vol 14 (6) ◽  
pp. 438-444 ◽  
Author(s):  
Alison R. Huppmann ◽  
Bruce R. Pawel
Keyword(s):  
Urinary Bladder ◽  
Pediatric Population ◽  
Low Grade ◽  
Nephrogenic Adenoma ◽  
Patient Demographics ◽  
Urothelial Tumors ◽  
Histologic Types ◽  
Cystitis Cystica ◽  
Pathology Review ◽  
Made In

Although not uncommon in adults, bladder tumors are rare in children. In addition, the histologic types of tumors seen in the pediatric population differ from those seen in adults. Although rhabdomyosarcoma is the most common pediatric bladder tumor, many other benign, malignant, and reactive lesions can be encountered. All may present clinically as a mass or polyp in the bladder. This study was designed to describe the pathology and patient demographics of pediatric bladder masses, because there are few studies describing these entities. Retrospectively reviewing our experience over a 21-year period, we identified 98 specimens from 65 patients with polyps or masses in the urinary bladder. As expected, the most frequent diagnosis was rhabdomyosarcoma. This was followed by fibroepithelial polyp and a variety of additional nonurothelial tumors. Only 7 urothelial tumors were identified, including 1 low-grade papillary urothelial carcinoma. Inflammatory lesions, such as cystitis cystica and nephrogenic adenoma, were invariably associated with an irritating factor when a history was provided. Our findings emphasize that diagnoses made in the pediatric urinary bladder are distinct from those in adults, although a wide variety of lesions may still be seen.

Neonatal Urinary Bladder Inflammation Produces Adult Bladder Hypersensitivity

2006 ◽  
Vol 7 (7) ◽  
pp. 469-479 ◽  
Author(s):  
Alan Randich ◽  
Tyler Uzzell ◽  
Jennifer J. DeBerry ◽  
Timothy J. Ness
Keyword(s):  
Urinary Bladder ◽  
Bladder Inflammation

scholarly journals Short-term effect of acute and repeated urinary bladder inflammation on thigmotactic behaviour in the laboratory rat

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 109 ◽  
Author(s):  
Rosemary H Morland ◽  
Amparo Novejarque ◽  
Wenlong Huang ◽  
Rachel Wodarski ◽  
Franziska Denk ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Open Field ◽  
Inflammatory Mediators ◽  
Depressive Disorders ◽  
Experimental Conditions ◽  
Bladder Inflammation ◽  
Female Wistar Rats ◽  
Qpcr Array ◽  
Behavioural Conflict ◽  
Affective Disturbances

Understanding the non-sensory components of the pain experience is crucial to developing effective treatments for pain conditions. Chronic pain is associated with increased incidence of anxio-depressive disorders, and patients often report feelings of vulnerability which can decrease quality of life. In animal models of pain, observation of behaviours such as thigmotaxis can be used to detect such affective disturbances by exploiting the influence of nociceptive stimuli on the innate behavioural conflict between exploration of a novel space and predator avoidance behaviour. This study investigates whether acute and repeated bladder inflammation in adult female Wistar rats increases thigmotactic behaviour in the open field paradigm, and aims to determine whether this correlates with activation in the central amygdala, as measured by c-Fos immunoreactivity. Additionally, up-regulation of inflammatory mediators in the urinary bladder was measured using RT-qPCR array featuring 92 transcripts to examine how local mediators change under experimental conditions. We found acute but not repeated turpentine inflammation of the bladder increased thigmotactic behaviour (decreased frequency of entry to the inner zone) in the open field paradigm, a result that was also observed in the catheter-only instrumentation group. Decreases in locomotor activity were also observed in both models in turpentine and instrumentation groups. No differences were observed in c-Fos activation, although a general increased in activation along the rostro-caudal axis was seen. Inflammatory mediator up-regulation was greatest following acute inflammation, with CCL12, CCL7, and IL-1β significantly up-regulated in both conditions when compared to naïve tissue. These results suggest that acute catheterisation, with or without turpentine inflammation, induces affective alterations detectable in the open field paradigm accompanied by up-regulation of multiple inflammatory mediators.

scholarly journals Expression and function of CXCL12/CXCR4 in rat urinary bladder with cyclophosphamide-induced cystitis

2010 ◽  
Vol 298 (3) ◽  
pp. F589-F600 ◽  
Author(s):  
Lauren Arms ◽  
Beatrice M. Girard ◽  
Margaret A. Vizzard
Keyword(s):  
Urinary Bladder ◽  
Tissue Injury ◽  
Bladder Capacity ◽  
Rat Urinary Bladder ◽  
Cxcr4 Signaling ◽  
Qrt Pcr ◽  
Proinflammatory Mediators ◽  
Bladder Inflammation ◽  
And Function

Chemokines, otherwise known as chemotactic cytokines, are proinflammatory mediators of the immune response and have been implicated in altered sensory processing, hyperalgesia, and central sensitization following tissue injury or inflammation. To address the role of CXCL12/CXCR4 signaling in normal micturition and inflammation-induced bladder hyperreflexia, bladder inflammation in adult female Wistar rats (175–250 g) was induced by injecting cyclophosphamide (CYP) intraperitoneally at acute (150 mg/kg; 4 h), intermediate (150 mg/kg; 48 h), and chronic (75 mg/kg; every 3rd day for 10 days) time points. CXCL12, and its receptor, CXCR4, were examined in the whole urinary bladder of control and CYP-treated rats using enzyme-linked immunosorbent assays (ELISAs), quantitative PCR (qRT-PCR), and immunostaining techniques. ELISAs, qRT-PCR, and immunostaining experiments revealed a significant ( P ≤ 0.01) increase in CXCL12 and CXCR4 expression in the whole urinary bladder, and particularly in the urothelium, with CYP treatment. The functional role of CXCL12/CXCR4 signaling in micturition was evaluated using conscious cystometry with continuous instillation of saline and CXCR4 receptor antagonist (AMD-3100; 5 μM) administration in control and CYP (48 h)-treated rats. Receptor blockade of CXCR4 using AMD-3100 increased bladder capacity in control (no CYP) rats and reduced CYP-induced bladder hyperexcitability as demonstrated by significant ( P ≤ 0.01) increases in intercontraction interval, bladder capacity, and void volume. These results suggest a role for CXCL12/CXCR4 signaling in both normal micturition and with bladder hyperreflexia following bladder inflammation.

scholarly journals Increased Expression of Interleukin-6 Family Members and Receptors in Urinary Bladder with Cyclophosphamide-Induced Bladder Inflammation in Female Rats

2011 ◽  
Vol 5 ◽  
Author(s):  
Beatrice M. Girard ◽  
Bopaiah P. Cheppudira ◽  
Susan E. Malley ◽  
Kristin C. Schutz ◽  
Victor May ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Interleukin 6 ◽  
Family Members ◽  
Female Rats ◽  
Bladder Inflammation
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