scholarly journals Fluid dynamic characteristics of a rotating shear stressor simulating rotary blood pumps.

2001 ◽  
Vol 13 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Ahmed Aouidef ◽  
Takashi Yamane ◽  
Osamu Maruyama ◽  
Masahiro Nishida
Keyword(s):  
Dynamic Characteristics ◽  
Fluid Dynamic ◽  
Blood Pumps ◽  
Rotary Blood Pumps

scholarly journals An accelerated thrombosis model for computational fluid dynamics simulations in rotary blood pumps

2021 ◽  
Author(s):  
Christopher Blum ◽  
Sascha Groß-Hardt ◽  
Ulrich Steinseifer ◽  
Michael Neidlin
Keyword(s):  
Platelet Activation ◽  
Clinical Data ◽  
Thrombus Formation ◽  
Fluid Dynamic ◽  
Surrogate Marker ◽  
Blood Pump ◽  
Funding Agency ◽  
Heartmate Ii ◽  
Blood Pumps ◽  
Rotary Blood Pumps

AbstractPurposeThrombosis is one of the major complications in blood-carrying medical devices and a better understanding to influence design of such devices is desirable. Over the past years many computational models of thrombosis have been developed. However, open questions remain about the applicability and implementation within a pump development process. The aim of the study was to develop and test a computationally efficient model for thrombus risk prediction in rotary blood pumps.MethodsWe used a two-stage approach to calculate thrombus risk. At the first stage, the velocity and pressure fields were computed by computational fluid dynamic (CFD) simulations. At the second stage, platelet activation by mechanical and chemical stimuli was determined through species transport with an Eulerian approach. The model was implemented in ANSYS CFX and compared with existing clinical data on thrombus deposition within the HeartMate II.ResultsOur model shows good correlation (R2>0.94) with clinical data and identifies the bearing and outlet stator region of the HeartMate II as the location most prone to thrombus formation. The calculation of platelet activation requires an additional 10-20 core hours of computation time.DiscussionThe concentration of activated platelets can be used as a surrogate marker to determine risk regions of thrombus deposition in a blood pump. Model expansion, e.g. by including more chemical species can easily be performed. We make our model openly available by implementing it for the FDA benchmark blood pump.DeclarationsFundingThis research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Open access funding enabled and organized by Projekt DEAL.Conflict of interestAll of the authors have nothing to disclose.Availability of data and materialThe raw data can be retrieved by request from the authors.Code availabilityThe implementation of the thrombus model in the FDA benchmark blood pump geometry is available on https://doi.org/10.5281/zenodo.5116063.Authors’ contributionsAll authors contributed to the study conception and design. CB developed the numerical model, performed the simulations, gathered, analysed and discussed the results. SGH, MN and US were involved in the analysis and discussion of the results. MN supervised the project. MN and CB wrote the manuscript based on the input of all co-authors. All co-authors read and approved the final version of the manuscript.

scholarly journals An Accelerated Thrombosis Model for Computational Fluid Dynamics Simulations in Rotary Blood Pumps

2022 ◽  
Author(s):  
Christopher Blum ◽  
Sascha Groß-Hardt ◽  
Ulrich Steinseifer ◽  
Michael Neidlin
Keyword(s):  
Clinical Data ◽  
Computational Models ◽  
Thrombus Formation ◽  
Fluid Dynamic ◽  
Operating Conditions ◽  
Model Parameters ◽  
Dynamic Simulations ◽  
Heartmate Ii ◽  
Blood Pumps ◽  
Rotary Blood Pumps

Abstract Purpose Thrombosis ranks among the major complications in blood-carrying medical devices and a better understanding to influence the design related contribution to thrombosis is desirable. Over the past years many computational models of thrombosis have been developed. However, numerically cheap models able to predict localized thrombus risk in complex geometries are still lacking. The aim of the study was to develop and test a computationally efficient model for thrombus risk prediction in rotary blood pumps. Methods We used a two-stage approach to calculate thrombus risk. The first stage involves the computation of velocity and pressure fields by computational fluid dynamic simulations. At the second stage, platelet activation by mechanical and chemical stimuli was determined through species transport with an Eulerian approach. The model was compared with existing clinical data on thrombus deposition within the HeartMate II. Furthermore, an operating point and model parameter sensitivity analysis was performed. Results Our model shows good correlation (R2 > 0.93) with clinical data and identifies the bearing and outlet stator region of the HeartMate II as the location most prone to thrombus formation. The calculation of thrombus risk requires an additional 10–20 core hours of computation time. Conclusion The concentration of activated platelets can be used as a surrogate and computationally low-cost marker to determine potential risk regions of thrombus deposition in a blood pump. Relative comparisons of thrombus risk are possible even considering the intrinsic uncertainty in model parameters and operating conditions.

Fluid Dynamic Characteristics of Monopivot Magnetic Suspension Blood Pumps

ASAIO Journal ◽  
1997 ◽  
Vol 43 (5) ◽  
pp. M639 ◽  
Author(s):  
TAKASHI YAMANE ◽  
MASAHIRO NISHIDA ◽  
BALAZS ASZTALOS ◽  
TATSUO TSUTSUI ◽  
TOMOAKI JIKUYA
Keyword(s):  
Dynamic Characteristics ◽  
Fluid Dynamic ◽  
Magnetic Suspension ◽  
Blood Pumps

Two implantable rotary blood pumps for biventricular heart failure

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
T Krabatsch ◽  
E Hennig ◽  
E Potapov ◽  
A Stepanenko ◽  
T Drews ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Pumps ◽  
Rotary Blood Pumps

A low hemolysis rate is not a sufficient criterion for the qualification of rotary blood pumps

2008 ◽  
Vol 56 (S 1) ◽  
Author(s):  
J Müller ◽  
M Brodde ◽  
P Nüsser ◽  
J Müller ◽  
K Graichen ◽  
...  
Keyword(s):  
Sufficient Criterion ◽  
Blood Pumps ◽  
Rotary Blood Pumps ◽  
Hemolysis Rate

CONDITION MONITORING OF ROTARY BLOOD PUMPS

ASAIO Journal ◽  
1997 ◽  
Vol 43 (2) ◽  
pp. 58 ◽  
Author(s):  
Vinay Jammu ◽  
Stanley Malanoski ◽  
Thomas Walter ◽  
William Smith
Keyword(s):  
Condition Monitoring ◽  
Blood Pumps ◽  
Rotary Blood Pumps

Rotary blood pumps in circulatory assist

Perfusion ◽  
1995 ◽  
Vol 10 (3) ◽  
pp. 153-158 ◽  
Author(s):  
H. Reul ◽  
P. Harbott ◽  
Th Siess ◽  
G. Rau
Keyword(s):  
Blood Pumps ◽  
Rotary Blood Pumps
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