scholarly journals CHALLENGE IN THE DIAGNOSIS OF INFECTION IN HOSPITALIZED SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS: EVALUATION OF CLINICAL MARKERS, CRP, NEUTROPHIL-LYMPHOCYTE RATIO AND PLATELET-LYMPHOCYTE RATIO

2019 ◽  
Author(s):  
JOANA STARLING CARVALHO ◽  
MARIA DAS GRAÇAS CARVALHO ◽  
ANA JULIA FURBINO DIAS BICALHO ◽  
GILDA APARECIDA FERREIRA
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Clinical Markers ◽  
Systemic Lupus ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Diagnosis Of Infection

scholarly journals The Relationship between Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio to Degree of Activity in Systemic Lupus Erythematosus

2021 ◽  
Vol 8 (10) ◽  
pp. 374-382
Author(s):  
Irsyadil Fikri ◽  
Zuhrial Zubir ◽  
Ananda Wibawanta Ginting
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Bivariate Analysis ◽  
Systemic Lupus ◽  
Autoantibody Production ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
The Relationship ◽  
Normally Distributed

Background: Systemic lupus erythematosus is a chronic autoimmune inflammatory disease with a wide spectrum of clinical and serological manifestations caused by autoantibody production, complement activation, and immune complex deposition. Several studies have shown that the neutrophil-lymphocyte ratio and the platelet-lymphocyte ratio are closely correlated with systemic lupus erythematosus and its disease activity so that they can be used as diagnostic indicators and monitoring of systemic lupus erythematosus. Objective: To determine the relationship between the ratio of neutrophil lymphocytes and the ratio of platelets to lymphocytes on the degree of activity of lupus disease in patients with systemic lupus erythematosus. Methods: This is an observational analytic study using medical record data from central installation patients at H. Adam Malik Hospital in the period January to December 2019. The sample was calculated using the unpaired comparative sample size formula for more than two groups of one measurement. Then the distribution test was carried out with the Shapiro Wilk test. Bivariate analysis was conducted to determine the relationship between the ratio of neutrophil lymphocytes and the ratio of platelets to lymphocytes with the MEX SLEDAI score using the ANOVA test if the data were normally distributed, or the Kruskal-Wallis test if the data was not normally distributed. Then proceed with the Mann-Whitney post hoc test to see which groups have differences. The sum of deviations (α) is 0.05, statistically significant if p<0.05. Results: 120 subjects participated in the study and 33 people (27.5%) had mild systemic lupus erythematosus, 47 (39.2%) moderate degrees, and 40 people (33.3%) severe degrees. Conclusion: The neutrophil-lymphocyte ratio and the platelet-lymphocyte ratio are associated with the degree of lupus activity in patients with systemic lupus erythematosus. Keywords: neutrophil-lymphocyte ratio, platelet lymphocyte ratio, systemic lupus erythematosus.

scholarly journals The Relationship between Neutrophil Lymphocyte Ratio with Disease Activity in Systemic Lupus Erythematosus

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Gede Kambayana ◽  
I Gusti Agung Friskha Surya Putra ◽  
Pande Ketut Kurniari ◽  
Tjokorda Raka Putra
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
The Relationship

Background. Systemic Lupus Erythematosus (SLE) is an Autoimmune inflammatory disease that is systemic and chronic inflammation with heterogeneous of history, clinical manifestations, and prognosis. The disease activity of SLE has been proven as a predictor of organ damage and death by evidenced of inflammatory markers involved in this disease. Neutrophil to Lymphocyte Ratio (NLR) is useful for estimating the activity of autoimmune disease and inflammation that easily obtained from blood test and low cost and measurable as new biomarker to assess inflammatory response or activity of SLE. This study aimed to determine the relationship between NRL and Disease Activity based on Mex-SLEDAI in patients SLE. Methods. This study is an analytic study with cross sectional design. It started from November 2016 until March 2017. Mex-SLEDAI and blood sampling used in this study. Result. Total sample in this study is 54 patients with median age was 28.5 years, with mostly female (85,2%). Result analysis with positive correlation between NLR with disease activity on SLE (r=0.399  p=0.003  n=54), thus the Scatter plot shows there is a correlation between NRL with Mex-SLEDAI. Conclusion. Positive correlation between NLR and disease activity of the SLE, the higher of the disease activity/Mex-SLEDAI will be followed by the increase of NLR.

scholarly journals The Relationship of Neutrophil Lymphocyte Ratio and Levels of Vitamin D against Disease Activity Systemic Lupus Erythematosus

2021 ◽  
Vol 8 (10) ◽  
pp. 320-325
Author(s):  
Ahmad Fauzi Lubis ◽  
Zuhrial Zubir ◽  
Ananda Wibawanta Ginting
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Systemic Lupus Erythematosus Disease ◽  
Systemic Lupus ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Vitamin D Levels ◽  
The Relationship

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the presence of autoantibodies against cell nuclei and immune complexes involving multiple organ systems in the body. The Lupus Foundation estimates about 1.5 million cases of SLE in America and at least 5 million cases of SLE in the world and from year to year, the number of people with lupus also tends to increase. Several laboratory findings are also associated with signs and symptoms of SLE activity including the ratio of neutrophil lymphocytes and vitamin D levels. Method: This study is an observational analytic study using medical record data from central installation patients at H. Adam Malik Hospital in the period December 2019 to March 2021. The sample is calculated using the large proportion estimation formula. Then the distribution test was carried out with the Shapiro Wilk test. Bivariate analysis was carried out to determine the relationship between neutrophil lymphocyte ratio and vitamin D levels with the MEX SLEDAI score using the ANOVA test if the data was normally distributed. Results: 75 subjects participated in the study and there were 12 people (16%) experiencing mild systemic lupus erythematosus, 38 people (51%) moderate degree, and 25 people (33%) severe degree. The neutrophil-lymphocyte ratio was associated with systemic lupus erythematosus disease activity (p=0.001) and vitamin D levels were associated with systemic lupus erythematosus disease activity. Conclusion: Neutrophil-lymphocyte ratio and vitamin D levels are associated with systemic lupus erythematosus disease activity. Keywords: neutrophil lymphocyte ratio, vitamin D levels, systemic lupus erythematosus.

scholarly journals Neutrophil-Lymphocyte Ratio as a Reliable Predictive Marker in Systemic Lupus Erythematosus

2018 ◽  
Vol 86 (3) ◽  
pp. 919-925
Author(s):  
HEBATU ALLAH A. EL-HABIBY, M.Sc.; NOHA E. ESHEBA, M.D. ◽  
ENAAM S. ABD EL-BAR, M.D.; GEHAN M. SHEIRA, M.D.
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Predictive Marker ◽  
Systemic Lupus ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

Cut off point of neutrophil-to-lymphocyte ratio as a marker of active disease in systemic lupus erythematosus

Lupus ◽  
2020 ◽  
Vol 29 (12) ◽  
pp. 1566-1570
Author(s):  
Akhmad Syaikhu Firizal ◽  
Adhi Kristianto Sugianli ◽  
Laniyati Hamijoyo
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Inflammatory Diseases ◽  
Activity Index ◽  
Disease Activity Index ◽  
Neutrophil To Lymphocyte Ratio ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Lymphocyte Ratio ◽  
Active Disease

Aim We aimed to measure sensitivity, specificity, and to determine the cut-off value (COV) ratio of neutrophil-to-lymphocyte (NLR) in patients with active systemic lupus erythematosus (SLE). Methods A cross sectional study was conducted using the retrospective data from Hasan Sadikin Lupus Registry (HSLR). The inclusion criteria were SLE patients aged 18 years or older who had documented data of neutrophil, lymphocyte, and SLE disease activity index (SLEDAI). Patients with infections, malignancies, and other inflammatory diseases recorded in registry were excluded. SLEDAI with a score of ≤ 4 is considered inactive and score of > 4 is considered active. The neutrophil-to-lymphocyte ratio was calculated by dividing the absolute number of neutrophils by the absoulte number of lymphocytes. Receiver Operating Characteristic (ROC) curve was used to analyze and determine optimal COV of NLR. Results The total sample in this study were 112 subjects with a dominant of female (95.54%) and the mean age of 34.45 ± 9.40 years. The median of SLEDAI was 4.5 with a range from 0 to 16, while the median of NLR was 2.68 with a range of 0.59 to 19.02. The ROC analysis showed the optimal cut-off in this study was 2.94 with sensitivity and specificity as high as 60.71% and 76.79%, respectively. Conclusion Neutrophil-to-lymphocyte ratio with cut off value of 2.94 can be used to determine active disease of systemic lupus eythematousus.

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