THU0305 A Nationwide Study of Systemic Lupus Erythematosus in Japanese Identified Subgroups of Patients with Clear Signs/Clinical Marker Patterns and Found that Particular Signs/Clinical Markers are Associated with Age and/or Sex

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A269.1-A269
Author(s):  
C. Terao ◽  
R. Yamada ◽  
T. Mimori ◽  
K. Yamamoto ◽  
T. Sumida
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Clinical Markers ◽  
Systemic Lupus ◽  
Clinical Marker ◽  
Nationwide Study

Occupational Risk Factors for Systemic Lupus Erythematosus: A Nationwide Study Based on Hospitalizations in Sweden

2012 ◽  
Vol 39 (4) ◽  
pp. 743-751 ◽  
Author(s):  
XINJUN LI ◽  
JAN SUNDQUIST ◽  
KRISTINA SUNDQUIST ◽  
BENGT ZÖLLER
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Lower Risk ◽  
Census Data ◽  
Construction Workers ◽  
Secondary Diagnosis ◽  
Systemic Lupus ◽  
Occupational Risk Factors ◽  
Nationwide Study ◽  
Increased Risk

Objective.To investigate possible associations between occupation and hospitalization for systemic lupus erythematosus (SLE) in a nationwide study.Methods.A nationwide database was constructed in Sweden by linking the Swedish Census to the Hospital Discharge Register to obtain data on all first hospitalizations with a primary or secondary diagnosis of SLE in adults during the study period (1970 to 2008). Standardized incidence ratios (SIR) and 95% CI were calculated for different occupations. Two cohorts were defined based on occupational titles recorded in Swedish census data in 1970 and 1980.Results.A total of 8921 male and 42290 female hospitalizations for SLE were retrieved in individuals aged over 15 years. High education (> 12 yrs) was associated with a lower risk of hospitalization for SLE among both women (SIR = 0.73) and men (SIR = 0.72). Among men with the same occupation in 2 consecutive censuses, increased risks (SIR) > 2.0 were present among artistic workers (2.52); shop managers and assistants (3.63); miners and quarry workers (6.04); shoe and leather workers (6.93); plumbers (2.21); other construction workers (2.08); glass, ceramic and tile workers (4.43); chimney sweeps (4.54); and military personnel (3.01). Among women with the same occupation in 2 consecutive censuses, no occupation was associated with SIR > 2.0.Conclusion.Occupation may carry significantly increased risk of hospital admission for SLE. Especially among men, several occupations were associated with increased risks for SLE.

scholarly journals Cervical neoplasia in systemic lupus erythematosus: a nationwide study

Rheumatology ◽  
2016 ◽  
pp. kew459 ◽  
Author(s):  
Hjalmar Wadström ◽  
Elizabeth V. Arkema ◽  
Christopher Sjöwall ◽  
Johan Askling ◽  
Julia F. Simard
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Cervical Neoplasia ◽  
Systemic Lupus ◽  
Nationwide Study

Tuberculosis as a risk factor for systemic lupus erythematosus: results of a nationwide study in Taiwan

2011 ◽  
Vol 32 (6) ◽  
pp. 1669-1673 ◽  
Author(s):  
Yu-Chao Lin ◽  
Shinn-Jye Liang ◽  
Yi-Heng Liu ◽  
Wu-Huei Hsu ◽  
Chuen-Ming Shih ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Risk Factor ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Nationwide Study

scholarly journals The Association among Antioxidant Enzymes, Autoantibodies, and Disease Severity Score in Systemic Lupus Erythematosus: Comparison of Neuropsychiatric and Nonneuropsychiatric Groups

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Yu-Jih Su ◽  
Tien-Tsai Cheng ◽  
Chung-Jen Chen ◽  
Wen-Chan Chiu ◽  
Wen-Neng Chang ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Activity Index ◽  
Disease Activity Index ◽  
Control Group ◽  
Clinical Markers ◽  
Systemic Lupus

Background. Antioxidative capacity plays an important role in the severity of systemic lupus erythematosus (SLE), which is characterized by autoantibodies. This study aimed to determine the relationship among autoantibody titers, antioxidative stress reserve, and severity of SLE.Methods. The autoantibody titers, clinical markers, antioxidant enzyme levels, and disease activity index (SLEDAI-2k) of 32 SLE patients and 16 healthy controls were compared. We also compared both the neuropsychiatric (NPSLE) and nonneuropsychiatric (non-NPSLE) groups.Results. Superoxide dismutase in red blood cells was significantly lower in the SLE than in the control group. CRP levels are significant higher in SLE patients than in control group (P=0.034). Among the autoantibodies, anti-U1RNPP=0.008, a-SmP=0.027, and anti-ribosomal pP=0.028significantly negatively correlated with glutathione levels. There has no significant correlation between SLE disease activity indexes (SLEDAI) and levels of C3, C4, and antioxidant enzymes.Conclusions. Erythrocyte superoxide dismutase is significantly lower in both NPSLE and non-NPSLE groups. SLE patients have both higher CRP and autoantibodies level and decreased superoxide dismutase level than the healthy control group.

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