scholarly journals Development and validation of a reversed phase liquid chromatographic method for the determination of three Gliptins and Metformin in the presence of Metformin impurity (1-cyanoguanidine)

2013 ◽  
Vol 4 (4) ◽  
pp. 444-449 ◽  
Author(s):  
Ramzia Ismail El-Bagary ◽  
Ehab Farouk Elkady ◽  
Bassam Mahfouz Ayoub
Keyword(s):  
Chromatographic Method ◽  
Reversed Phase ◽  
Liquid Chromatographic Method ◽  
Phase Liquid ◽  
Development And Validation ◽  
Liquid Chromatographic

scholarly journals Development and Validation of Liquid Chromatographic Method for Estimation of Ibuprofen and Famotidine in Combined Dosage Form

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Dimal A. Shah ◽  
Dixita J. Suthar ◽  
Sunil L. Baldania ◽  
Usman K. Chhalotiya ◽  
Kashyap K. Bhatt
Keyword(s):  
Mobile Phase ◽  
Dosage Form ◽  
Chromatographic Method ◽  
Reversed Phase ◽  
Assay Method ◽  
Liquid Chromatographic Method ◽  
Phase Liquid ◽  
Development And Validation ◽  
Liquid Chromatographic

An isocratic, reversed phase-liquid-chromatographic assay method was developed for the quantitative determination of ibuprofen and famotidine in combined-dosage form. A Brownlee C18, 5 μm column with mobile phase containing water : methanol : acetonitrile (30 : 60 : 10, v/v/v) was used. The flow rate was 1.0 mL/min, and effluents were monitored at 264 nm. The retention times of ibuprofen and famotidine were 4.9 min and 6.8 min, respectively. The linearity for ibuprofen and famotidine was in the range of 2–20 μg/mL and 0.1–10 μg/mL, respectively. The proposed method was validated with respect to linearity, accuracy, precision, specificity, and robustness. The method was successfully applied to the estimation of ibuprofen and famotidine in combined dosage form.

Liquid Chromatographic Method for Determination of Dithianon in Technical Products and Formulations: Collaborative Study

1995 ◽  
Vol 78 (5) ◽  
pp. 1131-1133
Author(s):  
Alan R Hanks
Keyword(s):  
Chromatographic Method ◽  
Collaborative Study ◽  
Reversed Phase ◽  
Study Data ◽  
Water Detection ◽  
Liquid Chromatographic Method ◽  
Phase Liquid ◽  
Liquid Chromatographic ◽  
Technical Products

Abstract A liquid chromatographic method for determination of dithianon in technical products and formulations was evaluated by 22 laboratories participating in a collaborative study. Data received from 19 laboratories were used in the statistical analysis. The study included 3 technical grade materials, 1 suspension concentrate, and 1 wettable powder. Dithianon is determined by reversed-phase liquid chromatography on a C18 column with a mobile phase of acetonitrile and water. Detection at 254 nm with peak area measurements is used with an external standard for quantitation of dithianon. The liquid chromatographic method for determination of dithianon in technical products and formulations has been adopted first action by AOAC INTERNATIONAL.

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