Synthesis, Characterization and Anticancer Evaluation of Novel Analogues of Pyrazoles

2021 ◽  
pp. 2162-2166
Author(s):  
Babli Khatun ◽  
Venkatesh Kamath ◽  
Muddukrishna B. S. ◽  
Aravinda Pai
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Mtt Assay ◽  
Cytotoxic Effect ◽  
Cancer Cell Lines ◽  
Lung Cancer Cell ◽  
Standard Doxorubicin

In the present study, a series of novel substituted pyrazole chalcones and pyrazole oximes (CF 1-15) were synthesized and characterized. Logp values were determined to assess their hydrophobicity. MTT (methyl tetrazolium) assay was performed on A-549 (lung cancer) cell lines. The MTT assay results showed the effect of various substituents on the pyrazole template that could influence their cytotoxic effect. Out of the 15 compounds screened against A-549 cell lines, the compound CF-6 showed appreciable cytotoxicity against the standard doxorubicin.

scholarly journals Chemosensitivity testing of human lung cancer cell lines using the MTT assay

1988 ◽  
Vol 57 (6) ◽  
pp. 540-547 ◽  
Author(s):  
J Carmichael ◽  
JB Mitchell ◽  
WG DeGraff ◽  
J Gamson ◽  
AF Gazdar ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Mtt Assay ◽  
Human Lung ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Chemosensitivity Testing ◽  
Human Lung Cancer Cell

scholarly journals Expression profiling of lung cancer cell lines

10.1038/87074 ◽  
2001 ◽  
Vol 27 (S4) ◽  
pp. 53-53
Author(s):  
Priya Dayananth ◽  
Terri McClanahan ◽  
Ferdous Gheyas ◽  
Marco Hernandez ◽  
Wei Ding ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Expression Profiling ◽  
Cancer Cell Lines ◽  
Lung Cancer Cell

scholarly journals Failure of apoptosis and activation on NFκB by celecoxib and aspirin in lung cancer cell lines

2007 ◽  
Author(s):  
Angela Gradilone ◽  
Ida Silvestri ◽  
Susanna Scarpa ◽  
Stefania Morrone ◽  
Orietta Gandini ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Lung Cancer Cell
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