scholarly journals The Use Of Stem Cells In The Treatment Of Sensorineural Hearing Loss

2021 ◽  
Vol 2 (2) ◽  
pp. 1-10
Author(s):  
Aubrey C Keller ◽  
Vincent S. Gallicchio
Keyword(s):  
Stem Cells ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing

scholarly journals Mesenchymal stem cells for sensorineural hearing loss: protocol for a systematic review of preclinical studies

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Kevin T. Chorath ◽  
Matthew J. Willis ◽  
Nicolas Morton-Gonzaba ◽  
Walter J. Humann ◽  
Alvaro Moreira
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Preclinical Studies

scholarly journals Exogenous IL-4-Expressing Bone Marrow Mesenchymal Stem Cells for the Treatment of Autoimmune Sensorineural Hearing Loss in a Guinea Pig Model

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Chang-qiang Tan ◽  
Xia Gao ◽  
Lang Guo ◽  
He Huang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Inner Ear ◽  
Sensorineural Hearing ◽  
Scala Tympani ◽  
Auditory Brain Stem Response ◽  
Marrow Mesenchymal Stem Cells

Bone marrow mesenchymal stem cells (BMSCs) expressing recombinant IL-4 have the potential to remediate inflammatory diseases. We thus investigated whether BMSCs expressing exogenous IL-4 could alleviate autoimmune sensorineural hearing loss. BMSCs isolated from guinea pigs were transfected with recombinant lentivirus expressing IL-4. A total of 33 animals were divided into three groups. Group A received scala tympani injection of IL-4-expressing BMSCs, and Group B received control vector-expressing BMSCs, and Group C received phosphate-buffered saline. The distribution of implanted BMSCs in the inner ears was assessed by immunohistochemistry and fluorescence microscopy. Auditory brain-stem response (ABR) was monitored to evaluate the auditory changes. Following BMSCs transplantation, the threshold levels of ABR wave III decreased in Groups A and B and significant differences were observed between these two groupsP<0.05. Transplanted BMSCs distributed in the scala tympani and scala vestibuli. In some ears with hearing loss, there was a decrease in the number of spiral ganglion cells and varying degrees of endolymphatic hydrops or floccule. Following transplantation, the lentivirus-infected BMSCs migrated to the inner ear and produced IL-4. Our results demonstrate that, upon transplantation, BMSCs and BMSCs expressing recombinant IL-4 have the ability to remediate the inflammatory injury in autoimmune inner ear diseases.

scholarly journals Functional Effects of Adult Human Olfactory Stem Cells on Early-Onset Sensorineural Hearing Loss

Stem Cells ◽  
2011 ◽  
Vol 29 (4) ◽  
pp. 670-677 ◽  
Author(s):  
Sonali R. Pandit ◽  
Jeremy M. Sullivan ◽  
Viktoria Egger ◽  
Alexander A. Borecki ◽  
Sharon Oleskevich
Keyword(s):  
Stem Cells ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Early Onset ◽  
Sensorineural Hearing ◽  
Adult Human

scholarly journals Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Muhammad Waqas ◽  
Iram Us-Salam ◽  
Zainab Bibi ◽  
Yunfeng Wang ◽  
He Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hearing Loss ◽  
Stem Cell ◽  
Sensorineural Hearing Loss ◽  
Hearing Aids ◽  
Hair Cells ◽  
Sensory Epithelium ◽  
Sensorineural Hearing ◽  
Sensory Structures ◽  
Ganglion Neurons

The hair cells that reside in the cochlear sensory epithelium are the fundamental sensory structures responsible for understanding the mechanical sound waves evoked in the environment. The intense damage to these sensory structures may result in permanent hearing loss. The present strategies to rehabilitate the hearing function include either hearing aids or cochlear implants that may recover the hearing capability of deaf patients to a limited extent. Therefore, much attention has been paid on developing regenerative therapies to regenerate/replace the lost hair cells to treat the damaged cochlear sensory epithelium. The stem cell therapy is a promising approach to develop the functional hair cells and neuronal cells from endogenous and exogenous stem cell pool to recover hearing loss. In this review, we specifically discuss the potential of different kinds of stem cells that hold the potential to restore sensorineural hearing loss in mammals and comprehensively explain the current therapeutic applications of stem cells in both the human and mouse inner ear to regenerate/replace the lost hair cells and spiral ganglion neurons.

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