ORGANIZATIONAL ASPECTS OF EARLY DIAGNOSIS AND TREATMENT OF SURGICAL SEPSIS IN THE CONDITIONS OF "CITY CLINICAL HOSPITAL №7" IN ALMATY

Vestnik ◽  
2021 ◽  
pp. 175-181
Author(s):  
М.Е. Рамазанов ◽  
М.Р. Рысулы ◽  
Н.Р. Рахметов ◽  
Б.К. Жанбырбай ◽  
В.Н. Сон ◽  
...  

Сепсис и септический шок являются одной из основных проблем здравоохранения. Ежегодно, по всему миру, он является причиной смерти более миллиона людей, при этом частота летальных исходов составляет примерно один случай из четырех. Летальность при тяжелом сепсисе и септическом шоке может достигать 30-90 процентов. На базе «ГКБ №7» УОЗ г. Алматы нами была разработана и внедрена алгоритм ранней диагностики и лечения сепсиса и современные методы применения биомаркеров диагностики и мониторинга сепсиса (акт внедрения от 01.06.2019г.), где основными показателями были сортировка по «Triage» системе на основе шкалы SOFA 3, определение современных биомаркеров как прокальцитонин и пресепсин. Так же определение гемокультуры, нейтрофильного лейкоцитоза, лактата, C-реактивного белка, и раннее применение эффективных антимикробных препаратов (в первый час) с момента постановки диагноза «септический шок» или «тяжелый сепсис», которые в свою очередь дали возможность своевременной фиксации признаков генерализации гнойного процесса и ранней диагностике осложнений. Упущение времени на этапе диагностики являются причиной возникновения в дальнейшем ошибок постановки окончательного диагноза и проведения соответствующего лечения. Многих ошибок можно избежать, если лечащие врачи будут точно следовать рекомендациям по ранней диагностике сепсиса и обоснованного выбора антимикробной терапии в каждом конкретном случае. На основании вышеизложенного, алгоритм разработанное и утвержденное руководством клиники «ГКБ №7», выполнение диагностических процедур адаптированную под диагностические возможности клиники, лечебную тактику пациентов с диагнозом «Сепсис» и налаженное система контроля над ее выполнением, - дало возможность к раннему выявлению генерализации гнойного процесса и развития тяжелого сепсиса или септического шока и соответственно привели к снижению летальности. Sepsis and septic shock are a major health problem. Globally, it causes more than a million deaths annually, with a death rate of about one in four. Mortality in severe sepsis and septic shock can be as high as 30-90 percent.On the basis of "City Clinical Hospital № 7" of the UOZ in Almaty, we have developed and implemented an algorithm for early diagnosis and treatment of sepsis and modern methods of using biomarkers for diagnosis and monitoring of sepsis (act of implementation dated 01.06.2019), where the main indicators were sorting according to "Triage" system based on the SOFA 3 scale, the definition of modern biomarkers such as procalcitonin and presepsin. Also, the determination of blood culture, neutrophilic leukocytosis, lactate, C-reactive protein, and the early use of effective antimicrobial drugs (in the first hour) from the moment of diagnosis of "septic shock" or "severe sepsis", which in turn made it possible to timely fix signs of generalization purulent process and early diagnosis of complications.Loss of time at the diagnostic stage is the reason for the subsequent occurrence of errors in the final diagnosis and appropriate treatment. Many mistakes can be avoided if the treating physicians strictly follow the recommendations for the early diagnosis of sepsis and the informed choice of antimicrobial therapy on a case-by-case basis.Based on the above, the algorithm developed and approved by the management of the clinic "City Clinical Hospital № 7", the implementation of diagnostic procedures adapted to the diagnostic capabilities of the clinic, the treatment tactics of patients diagnosed with "Sepsis" and an established monitoring system for its implementation, - made it possible to early detection of generalization of the purulent process and the development of severe sepsis or septic shock and, accordingly, led to a decrease in mortality.

2000 ◽  
Vol 26 (2) ◽  
pp. S148-S152 ◽  
Author(s):  
F. M. Brunkhorst ◽  
K. Wegscheider ◽  
Z. F. Forycki ◽  
R. Brunkhorst

2020 ◽  
Vol 8 (F) ◽  
pp. 218-225
Author(s):  
Yekaterina Y. Bulatova ◽  
Nurila A. Maltabarova ◽  
Murat B. Zhumabayev ◽  
Tatyana A. Li ◽  
Marina P. Ivanova

Sepsis is still one of the leading causes of child mortality worldwide, despite advances in its diagnosis and treatment. Difficulties in recognizing the transition of a localized infectious-inflammatory process to a generalized one lead to a belated diagnosis and the beginning of therapy. Meanwhile, the earlier treatment is started, the higher the patients’ chances of life. Early diagnosis of sepsis, which corresponds to modern ideas about this condition, is one of the main tasks for both scientists and practitioners. The aim of this review is to study modern recommendations for the diagnosis of sepsis and septic shock in children. The article reflects the epidemiology, etiological features, modern definitions, and methods of diagnosis of pediatric sepsis.


Critical Care ◽  
10.1186/cc469 ◽  
1999 ◽  
Vol 3 (Suppl 1) ◽  
pp. P095 ◽  
Author(s):  
FM Brunkhorst ◽  
K Wegscheider ◽  
ZF Forycki ◽  
R Brunkhorst

2000 ◽  
Vol 26 (S2) ◽  
pp. S148-S152 ◽  
Author(s):  
F. M. Brunkhorst ◽  
K. Wegscheider ◽  
Z. F. Forycki ◽  
R. Brunkhorst

MedPharmRes ◽  
2018 ◽  
Vol 2 (3) ◽  
pp. 27-32
Author(s):  
Bien Le ◽  
Dai Huynh ◽  
Mai Tuan ◽  
Minh Phan ◽  
Thao Pham ◽  
...  

Objectives: to evaluate the fluid responsiveness according to fluid bolus triggers and their combination in severe sepsis and septic shock. Design: observational study. Patients and Methods: patients with severe sepsis and septic shock who already received fluid after rescue phase of resuscitation. Fluid bolus (FB) was prescribed upon perceived hypovolemic manifestations: low central venous pressure (CVP), low blood pressure, tachycardia, low urine output (UOP), hyperlactatemia. FB was performed by Ringer lactate 500 ml/30 min and responsiveness was defined by increasing in stroke volume (SV) ≥15%. Results: 84 patients were enrolled, among them 30 responded to FB (35.7%). Demographic and hemodynamic profile before fluid bolus were similar between responders and non-responders, except CVP was lower in responders (7.3 ± 3.4 mmHg vs 9.2 ± 3.6 mmHg) (p 0.018). Fluid response in low CVP, low blood pressure, tachycardia, low UOP, hyperlactatemia were 48.6%, 47.4%, 38.5%, 37.0%, 36.8% making the odd ratio (OR) of these triggers were 2.81 (1.09-7.27), 1.60 (0.54-4.78), 1.89 (0.58-6.18), 1.15 (0.41-3.27) and 1.27 (0.46-3.53) respectively. Although CVP < 8 mmHg had a higher response rate, the association was not consistent at lower cut-offs. The combination of these triggers appeared to raise fluid response but did not reach statistical significance: 26.7% (1 trigger), 31.0% (2 triggers), 35.7% (3 triggers), 55.6% (4 triggers), 100% (5 triggers). Conclusions: fluid responsiveness was low in optimization phase of resuscitation. No fluid bolus trigger was superior to the others in term of providing a higher responsiveness, their combination did not improve fluid responsiveness as well.


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